Depletion of phosphorus may occur as a result of taking aluminum hydroxide. For those with kidney failure, reducing phosphorus absorption is the purpose of taking the drug, as excessive phosphorus levels can result from kidney failure. However, when people with normal kidney function take aluminum hydroxide for extended periods of time, it is possible to deplete phosphorus to unnaturally low levels.

Mineral oil has interfered with the absorption of many nutrients, including beta-carotene, phosphorus, potassium, and vitamins A, D, K, and E in some, but not all, research. Taking mineral oil on an empty stomach may reduce this interference. It makes sense to take a daily multivitamin-mineral supplement two hours before or after mineral oil. It is important to read labels, because many multivitamins do not contain vitamin K or contain inadequate (less than 100 mcg per day) amounts.

People taking sucralfate may develop lower than normal blood levels of phosphorus. A 42-year-old woman who took sucralfate for two weeks experienced bone pain that was caused by low phosphorus levels. The bone pain disappeared after she stopped taking the drug and began supplementing with phosphorus. Individuals taking sucralfate should have their blood phosphorus levels monitored regularly by their healthcare practitioner and may need to take supplemental phosphorus.