Nutritional Supplement

Maitake

Parts Used & Where Grown

Maitake is a very large mushroom, which grows deep in the mountains of northeastern Japan, as well as in North America and Europe. Famous for its taste and health benefits, maitake is also known as the “dancing mushroom.”1 Legend holds that those who found the rare mushroom began dancing with joy. Others attribute its name to the way the fruit bodies of the mushroom overlap each other, giving the appearance of dancing butterflies.

Maitake is extremely sensitive to environmental changes, which have presented many challenges to those cultivating this mushroom. However, Japanese farmers have succeeded in producing high-quality organic maitake mushrooms, allowing for wider availability both in Japan and the U.S. The fruiting body and mycelium of maitake are used medicinally.

How It Works

A common denominator among some mushrooms and some herbs is the presence of complex polysaccharides in their structure. These active constituents help support immune system function and are sometimes called immunomodulators. The polysaccharides present in maitake have a unique structure and are among the most powerful studied in test tubes to date.2 The primary polysaccharide, beta-D-glucan, is well absorbed when taken orally and is being studied as a potential tool for prevention and treatment of cancer and as a adjunctive treatment for HIV infection.3,4 Animal studies suggest maitake may lower serum cholesterol and triglycerides.5,6 However, this research is still preliminary and requires human trials for confirmation.

References

1. Hobbs C. Medicinal Mushrooms. Santa Cruz, CA: Botanica Press, 1995, 110-5.

2. Nanba H, Hamaguchi AM, Kuroda H. The chemical structure of an antitumor polysaccharide in fruit bodies of Grifola frondosa (maitake). Chem Pharm Bull 1987;35:1162-8.

3. Yamada Y, Nanba H, Kuroda H. Antitumor effect of orally administered extracts from fruit body of Grifola frondosa (maitake). Chemotherapy 1990;38:790-6.

4. Nanba H. Immunostimulant activity in vivo and anti-HIV activity in vitro of 3 branched b-1-6-glucans extracted from maitake mushrooms (Grifola frondosa). VIII International Conference on AIDS, Amsterdam, 1992 [abstract].

5. Kubo K, Nanba H. Anti-hyperliposis effect of maitake fruit body (Grifola frondosa). I. Biol Pharm Bull 1997;20:781-5.

6. Adachi K, Nanba H, Otsuka M, Kuroda H. Blood pressure lowering activity present in the fruit body of Grifola frondosa (maitake). Chem Pharm Bull 1988;36:1000-6.

7. Guo WL, Deng JC, Pan YY, et al. Hypoglycemic and hypolipidemic activities of Grifola frondosa polysaccharides and their relationships with the modulation of intestinal microflora in diabetic mice induced by high-fat diet and streptozotocin. Int J Biol Macromol 2020;153:1231–40.

8. Li L, Guo WL, Zhang W, et al. Grifola frondosa polysaccharides ameliorate lipid metabolic disorders and gut microbiota dysbiosis in high-fat diet fed rats. Food Funct 2019;10:2560–72.

9. Guo WL, Shi FF, Li L, et al. Preparation of a novel Grifola frondosa polysaccharide-chromium (III) complex and its hypoglycemic and hypolipidemic activities in high fat diet and streptozotocin-induced diabetic mice. Int J Biol Macromol 2019;131:81–8.

10. Ding Y, Xiao C, Wu Q, et al. The Mechanisms Underlying the Hypolipidaemic Effects of Grifola frondosa in the Liver of Rats. Front Microbiol 2016;7:1186.

11. Kubo K, Nanba H. Anti-hyperliposis effect of maitake fruit body (Grifola frondosa). I. Biol Pharm Bull 1997;20:781-5.

12. Bone K, Morgan M. Clinical Applications of Ayurvedic and Chinese Herbs. Warwick, Queensland, Australia: Phytotherapy Press, 1996, 13-20.

13. Nanba H. Antitumor activity of orally administered ‘D-fraction' from maitake mushroom (Grifola frondosa). J Naturopathic Med 1993;4:10-5.

14. Pengelly A. Medicinal fungi of the world. Modern Phytotherapist 1996;2:1, 3-8 [review].

15. Yamada Y, Nanba H, Kuroda H. Antitumor effect of orally administered extracts from fruit body of Grifola frondosa (maitake). Chemotherapy 1990;38:790-6.

16. Nanba H. Immunostimulant activity in vivo and anti-HIV activity in vitro of 3 branched b-1-6-glucans extracted from maitake mushrooms (Grifola frondosa). VIII International Conference on AIDS, Amsterdam, 1992 [abstract].

17. Hobbs C. Medicinal Mushrooms. Santa Cruz, CA: Botanica Press, 1995, 110-5.

Copyright © 2024 TraceGains, Inc. All rights reserved.

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The information presented by TraceGains is for informational purposes only. It is based on scientific studies (human, animal, or in vitro), clinical experience, or traditional usage as cited in each article. The results reported may not necessarily occur in all individuals. For many of the conditions discussed, treatment with prescription or over the counter medication is also available. Consult your doctor, practitioner, and/or pharmacist for any health problem and before using any supplements or before making any changes in prescribed medications. Information expires December 2024.

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