Nutritional Supplement

Cat′s Claw

Parts Used & Where Grown

Cat’s claw grows in the rain forests of the Andes Mountains in South America, particularly in Peru. The two species of the plant used most commonly are U. tomentosa, which makes up most of the cat’s claw imported to the U.S., and U. guianensis, which is more widely used in Europe. In South America, both species are used interchangeably. The root bark is used as medicine.

How It Works

According to test tube studies, oxyindole alkaloids in cat’s claw stimulate immune function.1 Alkaloids and glycosides in cat’s claw have also demonstrated anti-inflammatory and antioxidant activity.2,3

Although clinical trials are lacking, cat’s claw has become very popular in North America and is sometimes recommended for people with cancer or HIV infection. A cigarette smoker who took a freeze-dried extract of cat’s claw root bark for one month showed a sharp decrease in one urinary cancer marker.3 This finding, however, does little to support the use of the herb in persons with cancer and points toward the need for actual clinical studies to determine its effectiveness.

Cat’s claw has been used traditionally for osteoarthritis and rheumatoid arthritis. Double-blind trials have confirmed the effectiveness of cat's claw for each of these conditions.56

References

1. Keplinger H. Oxindole alkaloids having properties stimulating the immunologic system and preparation containing same. US Patent no. 5,302,611, April 12, 1994.

2. Aquino R, De Feo V, De Simone F, et al. Plant metabolites, new compounds and anti-inflammatory activity of Uncaria tomentosa. J Nat Prod 1991;54:453-9.

3. Rizzi R, Re F, Bianchi A, et al. Mutagenic and antimutagenic activities of Uncaria tomentosa and its extracts. J Ethnopharmacol 1993;38:63-77.

4. Piscoya J, Rodriguez Z, Bustamante SA, et al. Efficacy and safety of freeze-dried cat's claw in osteoarthritis of the knee: mechanisms of action of the species Uncaria guianensis. Inflamm Res 2001;50:442-8.

5. Mur E, Hartig F, Eibl G, Schirmer M. Randomized double blind trial of an extract from the pentacyclic alkaloid-chemotype of Uncaria tomentosa for the treatment of rheumatoid arthritis. J Rheumatol 2002;29:678-81.

6. Piscoya J, Rodriguez Z, Bustamante SA, et al. Efficacy and safety of freeze-dried cat's claw in osteoarthritis of the knee: mechanisms of action of the species Uncaria guianensis. Inflamm Res 2001;50:442-8.

7. Mur E, Hartig F, Eibl G, Schirmer M. Randomized double blind trial of an extract from the pentacyclic alkaloid-chemotype of Uncaria tomentosa for the treatment of rheumatoid arthritis. J Rheumatol 2002;29:678-81.

8. Keplinger H. Oxindole alkaloids having properties stimulating the immunologic system and preparation containing same. US Patent no. 5,302,611, April 12, 1994.

9. Keplinger UM. Influence of Krallendorn extract on retroviral infection. Zürcher AIDS Kongress Zurich, Switzerland, Oct 16-7, 1992 [abstract in German].

10. Keplinger UM. Therapy of HIV-infected individuals in the pathological categories CDC A1 and CDC B2 with a preparation containing IMM-207. IV. Österreichischer AIDS-Kongress, Vienna, Austria, Sept 17-8, 1993, 45 [abstract].

11. Foster S. Herbs for Your Health. Loveland, CO: Interweave Press, 1996, 18-9.

12. Foster S. Herbs for Your Health. Loveland, CO: Interweave Press, 1996, 18-9.

13. Cosentino C, Torres L. Reversible worsening of Parkinson's disease motor symptoms after oral intake of Uncaria tomentosa (cat's claw). Clin Neuropharmacol 2008;31:293-4.

Copyright © 2024 TraceGains, Inc. All rights reserved.

Learn more about TraceGains, the company.

The information presented by TraceGains is for informational purposes only. It is based on scientific studies (human, animal, or in vitro), clinical experience, or traditional usage as cited in each article. The results reported may not necessarily occur in all individuals. For many of the conditions discussed, treatment with prescription or over the counter medication is also available. Consult your doctor, practitioner, and/or pharmacist for any health problem and before using any supplements or before making any changes in prescribed medications. Information expires December 2024.

Log In

You need to log into the site to use this feature

Create A Free Account To Use Medicine Chest

This feature requires registration. Sign up or log in to your free WellRx account to gain access to this and other tools to help make managing your medications and wellness easier.

Benefits Include:

Store & manage your medication list
Medication pricing updates
Import medication from your pharmacy
Medication information
Pill & refill reminders
Medication journal & mood log

Sign up to use Medicine Chest

Create A Free Account To Use this feature

This feature requires registration. Sign up or log in to your free WellRx account to gain access to this and other tools to help make managing your medications and wellness easier.

Benefits Include:

Store & manage your medication list
Medication pricing updates
Import medication from your pharmacy
Medication information
Pill & refill reminders
Medication journal & mood log

Sign up to use this feature

You will be redirected to your program in 5 seconds.

Hi there.

Our Terms and Conditions and Privacy Policy have recently been updated.

Learn More


I Accept

By declining you will be logged out of your account

;