Nutritional Supplement

Bitter Melon

Parts Used & Where Grown

Bitter melon grows in tropical areas, including parts of East Africa, Asia, the Caribbean, and South America, where it is used as a food as well as a medicine. The fruit of this plant lives up to its name—it tastes bitter. Although the seeds, leaves, and vines of bitter melon have all been used, the fruit is the safest and most prevalent part of the plant used medicinally.

How It Works

At least three different groups of constituents in bitter melon have been reported to have blood-sugar lowering actions of potential benefit in diabetes mellitus. These include a mixture of steroidal saponins known as charantin, insulin-like peptides, and alkaloids. It is still unclear which of these is most effective, or if all three work together. Some clinical trials have confirmed the benefit of bitter melon for people with diabetes.1

In traditional herbal medicine, bitter melon—like other bitter-tasting herbs—is thought to stimulate digestive function and improve appetite. This has yet to be tested in human studies.

References

1. Raman A, Lau C. Anti-diabetic properties and phytochemistry of Momordica charantia L (Curcurbitaceae). Phytomed 1996;2:349-62.

2. Shivanagoudra S, Perera W, Perez J, et al. In vitro and in silico elucidation of antidiabetic and anti-inflammatory activities of bioactive compounds from Momordica charantia L. Bioorg Med Chem 2019;27:3097–109.

3. Yin R, Lee N, Hirpara H, Phung O. The effect of bitter melon (Mormordica charantia) in patients with diabetes mellitus: a systematic review and meta-analysis. Nutr Diabetes 2014;4:e145.

4. Ooi C, Yassin Z, Hamid T. Momordica charantia for type 2 diabetes mellitus. Cochrane Database Syst Rev 2012:Cd007845.

5. Peter E, Kasali F, Deyno S, et al. Momordica charantia L. lowers elevated glycaemia in type 2 diabetes mellitus patients: Systematic review and meta-analysis. J Ethnopharmacol 2019;231:311–24.

6. Cortez-Navarrete M, Martínez-Abundis E, Perez-Rubio K, et al. Momordica charantia Administration Improves Insulin Secretion in Type 2 Diabetes Mellitus. J Med Food 2018;21:672–7.

7. Inayat U, Khan R, Khalil Ur R, Bashir M. Lower hypoglycemic but higher antiatherogenic effects of bitter melon than glibenclamide in type 2 diabetic patients. Nutr J 2015;14:13.

8. Schulz V, Hänsel R, Tyler VE. Rational Phytotherapy: A Physician's Guide to Herbal Medicine. 3rd ed, Berlin: Springer, 1998, 168-73.

9. Blumenthal M, Busse WR, Goldberg A, et al. (eds). The Complete German Commission E Monographs: Therapeutic Guide to Herbal Medicines. Austin: American Botanical Council and Boston: Integrative Medicine Communications, 1998, 425-6.

10. Duke JA. CRC Handbook of Medicinal Herbs. Boca Raton, FL: CRC Press, 1985, 315-6.

11. Werbach MR, Murray MT. Botanical Influences on Illness. Tarzana, CA: Third Line Press, 1994, 139-41.

12. Brown DJ, Gaby A, Reichert R, Yarnell E. Phytotherapeutic and nutritional approaches to diabetes mellitus. Quart Rev Nat Med 1998;Winter:329-54.

Copyright © 2024 TraceGains, Inc. All rights reserved.

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The information presented by TraceGains is for informational purposes only. It is based on scientific studies (human, animal, or in vitro), clinical experience, or traditional usage as cited in each article. The results reported may not necessarily occur in all individuals. For many of the conditions discussed, treatment with prescription or over the counter medication is also available. Consult your doctor, practitioner, and/or pharmacist for any health problem and before using any supplements or before making any changes in prescribed medications. Information expires December 2024.

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