1. Kagan V, Khan S, Swanson C, et al. Antioxidant action of thioctic acid and dihydrolipoic acid. Free Radic Biol Med 1990;9S:15.
2. Gomes M, Negrato C. Alpha-lipoic acid as a pleiotropic compound with potential therapeutic use in diabetes and other chronic diseases. Diabetol Metab Syndr 2014;6:80.
3. Garcia-Alcala H, Santos Vichido C, Islas Macedo S, et al. Treatment with alpha-Lipoic Acid over 16 Weeks in Type 2 Diabetic Patients with Symptomatic Polyneuropathy Who Responded to Initial 4-Week High-Dose Loading. J Diabetes Res 2015;2015:189857.
4. Ziegler D, Low P, Litchy W, et al. Efficacy and safety of antioxidant treatment with alpha-lipoic acid over 4 years in diabetic polyneuropathy: the NATHAN 1 trial. Diabetes Care 2011;34:2054–60.
5. Udupa A, Nahar P, Shah S, et al. A comparative study of effects of omega-3 Fatty acids, alpha lipoic Acid and vitamin e in type 2 diabetes mellitus. Ann Med Health Sci Res 2013;3:442–6.
6. Zhao L, Hu F. Alpha-Lipoic acid treatment of aged type 2 diabetes mellitus complicated with acute cerebral infarction. Eur Rev Med Pharmacol Sci 2014;18:3715–9.
7. Okanovic A, Prnjavorac B, Jusufovic E, Sejdinovic R. Alpha-lipoic acid reduces body weight and regulates triglycerides in obese patients with diabetes mellitus. Med Glas (Zenica) 2015;12:122–7.
8. Nebbioso M, Pranno F, Pescosolido N. Lipoic acid in animal models and clinical use in diabetic retinopathy. Expert Opin Pharmacother 2013;14:1829–38.
9. Gebka A, Serkies-Minuth E, Raczynska D. Effect of the administration of alpha-lipoic acid on contrast sensitivity in patients with type 1 and type 2 diabetes. Mediators Inflamm 2014;2014:131538.
10. Hong Y, Peng J, Cai X, et al. Clinical Efficacy of Alprostadil Combined with alpha-lipoic Acid in the Treatment of Elderly Patients with Diabetic Nephropathy. Open Med (Wars) 2017;12:323–7.
11. Mitkov M, Aleksandrova I, Orbetzova M. Effect of transdermal testosterone or alpha-lipoic acid on erectile dysfunction and quality of life in patients with type 2 diabetes mellitus. Folia Med (Plovdiv) 2013;55:55–63.
12. Agathos E, Tentolouris A, Eleftheriadou I, et al. Effect of alpha-lipoic acid on symptoms and quality of life in patients with painful diabetic neuropathy. J Int Med Res 2018;46:1779–90.
13. Ametov A, Barinov A, Dyck P, et al. The sensory symptoms of diabetic polyneuropathy are improved with alpha-lipoic acid: the SYDNEY trial. Diabetes Care 2003;26:770–6.
14. Han Y, Wang M, Shen J, et al. Differential efficacy of methylcobalamin and alpha-lipoic acid treatment on symptoms of diabetic peripheral neuropathy. Minerva Endocrinol 2018;43:11–8.
15. Ziegler D, Ametov A, Barinov A, et al. Oral treatment with alpha-lipoic acid improves symptomatic diabetic polyneuropathy: the SYDNEY 2 trial. Diabetes Care 2006;29:2365–70.
16. Nebbioso M, Federici M, Rusciano D, et al. Oxidative stress in preretinopathic diabetes subjects and antioxidants. Diabetes Technol Ther 2012;14:257–63.
17. Gebka A, Serkies-Minuth E, Raczynska D. Effect of the administration of alpha-lipoic acid on contrast sensitivity in patients with type 1 and type 2 diabetes. Mediators Inflamm 2014;2014:131538.
18. Koh EH, Lee WJ, Lee SA, et al. Effects of alpha-lipoic acid on body weight in obese subjects. Am J Med 2011;124:85.e1-85.e8.
19. Bobe G,Michels AJ,Zhang WJ, et al. A Randomized Controlled Trial of Long-Term (R)-α-Lipoic Acid Supplementation Promotes Weight Loss in Overweight or Obese Adults without Altering Baseline Elevated Plasma Triglyceride Concentrations. The Journal of nutrition. 2020 09;150(9):2336-2345
20. Huerta AE, Navas-Carretero S, Prieto-Hontoria PL, et al. Effects of alpha-lipoic acid and eicosapentaenoic acid in overweight and obese women during weight loss. Obesity 2015;23:313–21.
21. Li N,Yan W,Hu X, et al. Effects of oral α-lipoic acid administration on body weight in overweight or obese subjects: a crossover randomized, double-blind, placebo-controlled trial. Clinical endocrinology. 2017 May;86(5):680-687
22. Kucukgoncu S,Zhou E,Lucas KB, et al. Alpha-lipoic acid (ALA) as a supplementation for weight loss: results from a meta-analysis of randomized controlled trials. Obesity reviews : an official journal of the International Association for the Study of Obesity. 2017 05;18(5):594-601
23. Namazi N,Larijani B,Azadbakht L. Alpha-lipoic acid supplement in obesity treatment: A systematic review and meta-analysis of clinical trials. Clinical nutrition (Edinburgh, Scotland). 2018 04;37(2):419-428
24. Magis D, Ambrosini A, Sandor P, et al. A randomized double-blind placebo-controlled trial of thioctic acid in migraine prophylaxis. Headache 2007;47:52-7.
25. Filina AA, Davydova NG, Endrikhovskii SN, et al. Lipoic acid as a means of metabolic therapy of open-angle glaucoma. Vestn Oftalmol 1995;111:6-8.
26. Dell'Anna ML, Mastrofrancesco A, Sala R, et el. Antioxidants and narrow band-UVB in the treatment of vitiligo: a double-blind placebo controlled trial. Clin Exp Dermatol 2007;32:631-6.
Store & manage your medication list
Medication pricing updates
Import medication from your pharmacy
Pill & refill reminders
Medication journal & mood log