Weight Loss And Obesity

Health Condition

Weight Loss and Obesity

  • Scales

    Many people track body weight to ensure they stay in a healthy range, and for the millions of people who go on a weight-loss diet each year, a good-quality scale is an essential tool. As you choose a scale, keep the following in mind.

    • Health insurance may cover the cost of a home scale, or you may be able to use a health savings account to pay for one. Call your insurance provider to find out before making your purchase.
    • Place the scale on a flat, hard surface for the most accurate readings.
    • Heavier weight that makes it difficult for scales to shift around can be an indication of higher quality.
    • Before purchasing, weigh yourself five times in a row. If you get the same number all five times, the scale has good precision.
    • To check accuracy, compare weight from your home scale against weight on an upright scale at a doctor’s office. These numbers should be the same or very close to one another.
    • Many things cause short-term weight fluctuations, including how much and what you’ve eaten, whether you’ve exercised recently, whether you’re properly hydrated, what you’re wearing, and time of day. Weigh yourself once per week or less if you’re trying to lose weight; daily fluctuations can lead to dieting frustration.
    • Basic Mechanical Scale (Dial)

      What they are: Mechanical, or analog, scales have a dial readout displaying weight in pounds and kilograms.

      Why to buy: Mechanical scales tend to be less expensive, don’t require a battery, may come with extra large numbers for ease of use, and are the simplest to use.

      Things to consider: Over time, mechanical scales may consistently add or subtract a few pounds. Most come with a tension knob to adjust the scale as required

    • Digital Scale with Added Features

      What they are: These scales give a digital (and sometimes audio) readout of weight.

      Why to buy: Digital scales may have features to allow storing and tracking weight over time, may have the ability to switch between pounds and kilograms, and may provide voice readouts of weight. If several family members are using one scale, consider a model with a multiple-user memory function.

      Things to consider: If you’re concerned about cost and ease of use, a mechanical scale may be a better choice. Digital scales require batteries, which need to be replaced when they wear out, so consider buying a rechargeable set for best value.

    • Digital Scale with Full Features

      What they are: Digital scales with full features can measure and track body weight, body mass index, percent body fat and lean body mass, hydration status, and bone mass.

      Why to buy: These models are a good choice for those who want the most information about weight and related measures. Tracking fat and lean body mass can motivate some people to more consistently follow a healthy diet and exercise plan.

      Things to consider: Extra features often mean higher cost. These models provide an idea of fat and lean mass, bone mass, and hydration, but are not always completely accurate. You should not rely on results from these scales to make important medical decisions. Digital scales require batteries, which need to be replaced when they wear out, so consider buying a rechargeable set for best value.

  • Blood Pressure Monitors

    Blood pressure is an important marker of health and a home blood pressure monitor is a wonderful tool for ensuring your numbers stay in the healthy range. A home monitor may lead to savings in health care costs, because you may need fewer visits to the doctor’s office, and it has the advantage of eliminating “white coat hypertension,” the falsely high blood pressure readings that can occur due to the stress of being in the doctor’s office.

    All blood pressure monitors have three key parts: the cuff, the gauge, and the stethoscope. On many models, the stethoscope is a built in sensor. Use this buying guide to find the right monitor to fit your health needs, lifestyle, and budget. As you choose a blood pressure monitor, keep the following in mind:

    • If you have an abnormal heartbeat, home readings can be inaccurate. Talk to your doctor about whether this is a concern for you.
    • Your health insurance may partially or fully cover the cost of a home blood pressure monitor. Call to find out before you purchase one.
    • If your arm is smaller or larger than average, you may need a smaller or larger cuff. If you are unsure whether an arm cuff will fit, ask the pharmacist if you can try before buying.
    • Manual Monitors

      What they are: With manual monitors, the user inflates the cuff around the arm and listens for the pulse through a stethoscope to determine blood pressure as the cuff deflates.

      Why to buy: Once you master their use, manual monitors are accurate and less expensive than most automated models.

      Things to consider: Manual monitors are more difficult to use than automated models, requiring more practice to learn or even another person to operate it.

    • Semi-Automatic & Automatic Arm Sleeve Monitors

      What they are: These devices have built-in stethoscopes with readings displayed on a digital screen. With semi-automatic monitors, the user inflates the cuff, while fully automatic monitors inflate the cuff for you. 

      Why to buy: These monitors typically are more expensive than manual options, but may vary in price depending on features. If you are looking for the most accurate and easiest way to store and track blood pressure readings over time, these models are a good option. 

      Things to consider: If you’re more concerned about cost than ease of use, manual options may be a better choice.

    • Wrist & Finger Monitors

      What they are: These newer devices allow a smaller cuff to be placed on the wrist or on a finger, instead of on the upper arm. 

      Why to buy: Putting on and taking off these monitors is easier than manipulating an arm cuff.  

      Things to consider: Although they tend to fall in the same cost range as automatic arm monitors, these monitors tend to be less accurate and lead to more errors than arm cuff monitors.

    • Advanced Features

      What they are: Depending on your budget and health tracking needs, you may want to consider spending extra dollars to purchase a digital monitor with more advanced features, including memory to store readings over time and computer software to track and graph your readings on a computer or mobile device. 

      Why to buy: Advanced features allow you to track blood pressure over time. Along with a few observations and notes, this can help you uncover connections between your behaviors, such as what you’ve eaten or how much you’ve exercised, and your blood pressure readings. Understanding these connections can help you take positive, effective actions to improve your health. 

      Things to consider: Advanced features cost more and may take more time to learn how to use. Many come with good instructions but if you’re uncomfortable with computers you may find these features take significant effort to learn and use.

  • Appetite Suppressants

    If you’re interested in losing weight, you’re in good company: millions of dieters spend billions of dollars on diet-related products and services each year. Taming the appetite is a logical component of a weight-loss plan, and our guide to appetite-suppressant products will help you choose products to meet your health, lifestyle, and budget needs. Keep the following in mind as you learn about appetite suppressants:

    • If you haven’t changed your eating or exercise habits and you’ve experienced recent or rapid weight gain, consult your doctor. These symptoms may signal a serious health problem.
    • Always clear new supplements with your healthcare provider before you begin taking them.
    • If you are already managing a health condition, especially heart disease, high blood pressure, kidney or liver disease, or mental health issues, consider your medications when selecting an appetite suppressant. It’s always wise to consult your doctor or pharmacist when mixing medications.
    • Many herbal weight-loss products are safe for short-term use only. Carefully follow all package directions and do not use products for longer than recommended.
    • If you experience serious or unpleasant side effects while taking an appetite suppressant, discontinue use and call your doctor.
    • Always compare ingredients to avoid accidentally doubling up on any one active ingredient.
    • Do not use appetite suppressants if you are pregnant or nursing.
    • Only use products that provide a complete ingredient list.
    • Herbs & Plants

      What they are: Numerous herbal and plant products on the market may suppress appetite. These include bitter orange (hydroxycitric acid), capsaicin (cayenne or red pepper), fucoxanthin, garcinia, glucomannan, green tea, guarana, guar gum, hoodia, yerba mate, and others.

      Why to buy: Some medical studies have suggested that certain herbal and plant-based appetite suppressants and weight loss products, such as green tea extract, may be effective for promoting weight loss. Fiber-containing substances, such as glucomannon and guar gum, may enhance feelings of fullness without unpleasant side effect such as rapid heart rate or insomnia.

      Things to consider: Do not use these products without consulting your doctor if you have high blood pressure, heart disease or irregular heartbeats, thyroid problems, diabetes, liver disease, kidney disease, or are taking medications to treat depression or other mental health issues. Some herbal appetite suppressants can cause unpleasant and potentially dangerous side effects including irritability, anxiety, insomnia, headaches, nausea, dizziness, rapid heart rate, and high blood pressure. Some herbal products, such as guarana and yerba mate, are potent sources of caffeine.

    • Other Products

      What they are: Non-herbal appetite suppressants include products and substances such as:

      • caffeine—whether from natural sources or added to products, caffeine is an appetite suppressant
      • chitosan—starch derived from the skeletons of shellfish
      • chromium—a mineral involved in balancing blood sugar
      • conjugated linoleic acid (CLA)—a type of fat found in dairy products
      • pyruvate or pyruvic acid—a substance the body naturally produces after carbohydrate and protein digestion
      • tastants—a combination of ingredients such as maltodextrin (starch), tricalcium phosphate, silica, and soy; according to the creator of one of these products it, “is intended to work with your sense of smell, fooling your brain and stomach into thinking you're full”

      Why to buy: Non-herbal appetite suppressants may have fewer of the side effects associated with herbal products, such as irritability, anxiety, rapid heart rate, and insomnia. Some natural appetite suppressants, such as CLA, pyruvate, and chromium, may promote weight loss, according to medical studies.

      Things to consider: Do not use these products without consulting your doctor if you have high blood pressure, heart disease or irregular heart beats, thyroid problems, diabetes, liver disease, kidney disease, or are taking medications to treat depression or other mental health issues. Chromium can be toxic in high doses.

    • Prescription Appetite-Suppressant Medications

      What they are: Currently approved prescription appetite-suppressant medications include phentermine, diethylpropion, phendimetrazine, and benzphetamine. Phentermine is the most commonly prescribed of the available prescription appetite suppressants.

      Why to buy: These medications have been studied and proven to assist with weight loss when combined with a healthy diet and regular physical activity.

      Things to consider: These medications are intended for short-term use, typically up to 12 weeks, under a doctor’s supervision. They may not be safe for people with high blood pressure, heart disease or irregular heart beats, thyroid problems, diabetes, liver disease, or kidney disease. Side effects can be unpleasant and include irritability, anxiety, nervousness, insomnia, headaches, nausea, dizziness, rapid heart rate, and high blood pressure.

  • Pedometers

    Walking is a fun and relatively easy way to get heart-healthy cardio while burning fat and calories. To maintain a healthy weight and stay active, try walking about 10,000 steps each day (approximately five miles). Do you want to lose a few extra pounds? Just step up the amount of walking each day. Whatever your goals, a pedometer is an easy way to keep track of your steps on the road to success.

    Remember to check with your doctor before starting any exercise program, especially if you are overweight or managing a health condition.

    • Basic Pedometers

      What they are:A pedometer is a small device, usually worn on your belt or clipped to a pocket, which counts how many steps you take in a day. There are two types:

      • Pendulum: Placement of a pendulum pedometer is vital for accuracy and they must remain in a vertical position on the hip or waist band.
      • Piezoelectric accelerometers: These can be placed anywhere on the front of the body, and some can even be kept in a pocket or on a neck lanyard and still provide accurate step counts.

      Most pedometers weigh only a few ounces and include a security strap to attach to clothing to prevent you from losing it.

      Why to buy: Pedometers are an easy way to track your daily exercise and overall health. Beyond counting steps, many pedometers track the distance in miles, amount of time you’ve been active, and total calories burned.

      Things to consider: When choosing a pedometer, consider the size of the display screen and the ease of reading results. Pendulum-style pedometers are generally less expensive than accelerometers, but the counting of incidental steps can be frustrating. Advantages of accelerometer pedometers are there are no moving parts and they remain silent as they record every step you take. Remember you’ll need to set your average step length or stride length in order for the pedometer to be accurate. Read the instructions on your pedometer carefully; most ask for the step length and explain how to measure it properly. Also note that some pedometers reset at midnight so you’re ready to go each morning, while others require you to manually reset them. Look at whether you need to change the batteries regularly or if it’s rechargeable through a USB connection to your computer.

    • Specialized Pedometers

      What they are: Monitors that help you measure steps plus other tracking, such as heart rate, calories burned, and so on.

      Why to buy: Pedometers with features that track heart rate and so on are handy for keeping an eye on your cardiovascular health, too. More advanced models include a memory function to save your accomplishments and some can upload data to a website, so you can easily track your results online and share with your doctors and friends.

      Things to consider: When investing in tools to support your health goals, sometimes simplest is best, but other times it can be helpful to combine goals and look for a device that will give you other helpful information, such as heart rate or trackable online information.

  • Heart Rate Monitors

    Heart rate monitors vary in size and function, but most are easy to use and provide valuable insights that support your exercise goals. For example, a heart rate monitor may help you stay in your target heart rate zone while exercising so you can safely focus on burning fat or improving your cardiovascular fitness. People with certain health conditions may use heart rate monitors to track their heart rate throughout the day and catch issues early. Heart rate monitors may also help keep exercise safe for people who, due to health conditions, should not exceed specific levels.

    Remember to always consult a doctor before starting any exercise routine, particularly if you are overweight or managing health conditions.

    • Basic Digital Heart Rate Monitors

      What they are: Many heart rate monitors look and function similarly to a wristwatch. Simple heart rate monitors measure your pulse in beats per minute while advanced models keep a history of readings and track data like irregular heartbeats and average and maximum heart rates. Some monitors even offer display text in multiple languages including English, German, French, and Spanish.

      Why to buy: Measuring your heart rate is important for getting the most out of your workouts, and can be especially important if you have heart health concerns. Most monitors save results by date and time, some for more than one user, and many have averaging functions so you get a feel for how your heart is doing over time.

      Things to consider: Many heart rate monitors include a chest strap that sends a wireless signal to the monitor on your wrist. Other heart rate monitors attach to your wrist or finger where your pulse rate may be counted through the skin. While comfort is one consideration, keep in mind that some experts believe chest straps are most accurate. Check which types of batteries the monitor takes and make sure you can replace them yourself. Look for features such as power-saving modes and low-battery indicators.

    • Multipurpose, Multimedia Monitors

      What they are: Usually worn on your wrist or arm, all-in-one digital devices may measure heart rate, calories burned, number of steps taken, and more. Look for those that combine a heart rate monitor with other interesting tools, like GPS sports watches and mp3 players. Some monitors even interface with exercise equipment or computer software to give you more detail and allow the sharing of results with your doctor or personal trainer.

      Why to buy: Multipurpose monitors provide a better overall picture of your health by tracking multiple factors in one place and cutting down on the number of different gadgets you need. Combining music with your workout makes it a lot more fun.

      Things to consider: Make sure the monitor is easy for you to use—pay attention to the size of the screen and buttons, how easy it is to switch between operating modes, how long the battery lasts, and so forth. When using a device for multiple purposes, you may use power more quickly and have to replace or recharge batteries more often. Online user reviews can be helpful when choosing a device combined with a heart rate monitor.

    • Specialty Heart Rate Monitors

      What they are: Heart rate monitors are sometimes designed to meet other needs, such as water-resistant and waterproof models. There are even heart rate monitors for cyclists to attach to their bikes, which can record data such as bike speed, pedal rpms, and elevation as well.

      Why to buy: If you’re going to wear your heart rate monitor outdoors in rain, snow, or other wet weather, look for ones rated as water resistant. If there’s a possibility your heart rate monitor will get submerged in water, even for a short time period, you’ll need one that’s waterproof.

      Things to consider: There are varying degrees of “water resistant” depending on how much moisture exposure the device can handle, so read labels carefully and err on the side of caution.

    • Fingertip Heart Rate Monitors

      What they are: Fingertip heart rate monitors—which measure your heart rate through the skin in a few short seconds—are rapidly growing in popularity.

      Why  to buy: They’re a portable, easy-to-use version of a heart rate monitor that you can carry in your pocket or purse and use on the go.

      Things to consider: Some experts believe fingertip heart rate monitors are not as accurate as the chest strap versions. Many fingertip monitors are small, so make sure you can easily read the display screen and operate any buttons.

  • Natural Digestion Aids

    From indigestion to constipation, digestion woes can ruin anyone’s day. If you suffer with these issues from time to time, a natural digestion aid may be just what you need to get your body back on track. Our guide to digestion aids will help you find the right products to meet your health and lifestyle needs. Keep the following in mind as you choose a digestion aid.

    • If you haven’t changed your eating habits and you’re experiencing new symptoms such as constipation, diarrhea, or heartburn on a regular basis, consult your doctor. These symptoms may signal a more serious health problem.
    • When selecting a product, consider medications you use and health conditions you have. Consult your doctor or pharmacist if unsure about whether any particular digestion aid is safe for you.
    • When using multiple products, always compare ingredients to avoid accidentally doubling up on any one particular active ingredient.
    • Read labels carefully to ensure you pick the right products to meet your particular digestion issues; some products are designed to address several problems at once, others only one issue at a time.
    • If you are pregnant or nursing, consult your doctor before using digestion aids.
    • Do not use any products for which a complete ingredient list is not provided.
    • Teas

      What they are: Teas to address a particular digestion issue contain an ingredient, or combination of ingredients, such as:

      • Ginger, fennel, fenugreek, or chamomile for nausea, indigestion, and heartburn (acid reflux)
      • Peppermint for nausea (good for nausea, but may worsen heartburn)
      • Parsley or fennel for gas and bloating
      • Slippery elm or meadow sweet for intestinal discomfort and spasms
      • Aloe, senna, cascara, or burdock root for constipation

      Why to buy: Herbal teas are generally safe and easy to use, offer gentle relief for occasional digestion woes, and are relatively inexpensive.

      Things to consider: Teas for constipation can have strong laxative effects in some people; start with a quarter to half cup serving and see how your body responds. Increase the dose as needed to relieve constipation. Pregnant women, people with kidney problems, high blood pressure, or heart disease, or those who are taking diuretic medications should consult their doctor before using digestion teas.

    • Herbal Capsules

      What they are: Natural digestion aids are available in capsule or tablet form and contain many of the same herbs found in digestion aid teas.

      Why to buy: Digestion aid capsules are more convenient; they can be carried with you and taken anytime, without the need to boil water to make tea. Capsules may deliver a more concentrated dose of the active ingredient than tea.

      Things to consider: As with teas, products for constipation can have strong laxative effects, so start slow and increase the dose only as needed. Consult your doctor or pharmacist before using these products if you are pregnant, or have kidney problems, high blood pressure, or heart disease, or take diuretic medications.

References

1. Flegal KM, Carroll MD, Ogden CL, Johnson CL. Prevalence and trends in obesity among US adults 1999-2000 JAMA 2002;288:1723-7.

2. Mokdad AH, Serdula MK, Dietz WH, et al. The continuing epidemic of obesity in the United States. JAMA 2000;284:1650-1 [letter].

3. Lewis CE, Jacobs DR Jr, McCreath H, et al. Weight gain continues in the 1990s: 10-year trends in weight and overweight from the CARDIA study. Coronary Artery Risk Development in Young Adults. Am J Epidemiol 2000;151:1172-81.

4. National Heart, Lung, and Blood Institute. Clinical Guidelines on the Identification, Evaluation, and Treatment of Overweight and Obesity in Adults: The Evidence Report. NIH Publication No. 98-4083. Washington DC: National Institutes of Health, 1998.

5. Emery EM, Schmid TL, Kahn HS, Filozof PP. A review of the association between abdominal fat distribution, health outcome measures, and modifiable risk factors. Am J Health Promot 1993;7:342-53 [review].

6. Brochu M, Poehlman ET, Ades PA. Obesity, body fat distribution, and coronary artery disease. J Cardiopulm Rehabil 2000;20:96-108 [review.]

7. Fine JT, Colditz GA, Coakley EG, et al. A prospective study of weight change and health-related quality of life in women. JAMA 1999;282:2136-42.

8. Calle EE, Thun MJ, Petrelli JM, et al. Body-mass index and mortality in a prospective cohort of U.S. adults. N Engl J Med 1999;341:1097-105.

9. Miller WC. How effective are traditional dietary and exercise interventions for weight loss? Med Sci Sports Exerc 1999;31:1129-34 [review].

10. Kassirer JP, Angell M. Losing weight—an ill-fated New Year's resolution. N Engl J Med 1998;338:52-4.

11. Muls E, Kempen K, Vansant G, Saris W. Is weight cycling detrimental to health? A review of the literature in humans. Int J Obes Relat Metab Disord 1995;19 Suppl 3:S46-S50 [review].

12. Brownell KD, Rodin J. Medical, metabolic, and psychological effects of weight cycling. Arch Intern Med1994;154:1325-30 [review].

13. Miller WC, Jacob AV. The health at any size paradigm for obesity treatment: the scientific evidence. Obes Rev 2001;2:37-45 [review].

14. Salamone LM, Cauley JA, Black DM, et al. Effect of a lifestyle intervention on bone mineral density in premenopausal women: a randomized trial. Am J Clin Nutr 1999;70:97-103.

15. Koh EH, Lee WJ, Lee SA, et al. Effects of alpha-lipoic acid on body weight in obese subjects. Am J Med 2011;124:85.e1-85.e8.

16. Bobe G,Michels AJ,Zhang WJ, et al. A Randomized Controlled Trial of Long-Term (R)-α-Lipoic Acid Supplementation Promotes Weight Loss in Overweight or Obese Adults without Altering Baseline Elevated Plasma Triglyceride Concentrations. The Journal of nutrition. 2020 09;150(9):2336-2345

17. Huerta AE, Navas-Carretero S, Prieto-Hontoria PL, et al. Effects of alpha-lipoic acid and eicosapentaenoic acid in overweight and obese women during weight loss. Obesity 2015;23:313–21.

18. Li N,Yan W,Hu X, et al. Effects of oral α-lipoic acid administration on body weight in overweight or obese subjects: a crossover randomized, double-blind, placebo-controlled trial. Clinical endocrinology. 2017 May;86(5):680-687

19. Kucukgoncu S,Zhou E,Lucas KB, et al. Alpha-lipoic acid (ALA) as a supplementation for weight loss: results from a meta-analysis of randomized controlled trials. Obesity reviews : an official journal of the International Association for the Study of Obesity. 2017 05;18(5):594-601

20. Namazi N,Larijani B,Azadbakht L. Alpha-lipoic acid supplement in obesity treatment: A systematic review and meta-analysis of clinical trials. Clinical nutrition (Edinburgh, Scotland). 2018 04;37(2):419-428

21. Barrett M, Udani J. A proprietary alpha-amylase inhibitor from white bean (Phaseolus vulgaris): a review of clinical studies on weight loss and glycemic control. Nutr J 2011;10:24.

22. Tucci SA,Boyland EJ,Halford JC. The role of lipid and carbohydrate digestive enzyme inhibitors in the management of obesity: a review of current and emerging therapeutic agents. Diabetes, metabolic syndrome and obesity : targets and therapy. 2010 May;3:125-43

23. Wang S,Chen L,Yang H, et al. Regular intake of white kidney beans extract (Phaseolus vulgaris L.) induces weight loss compared to placebo in obese human subjects. Food science & nutrition. 2020 Mar;8(3):1315-1324

24. Celleno L,Tolaini MV,D'Amore A, et al. A Dietary supplement containing standardized Phaseolus vulgaris extract influences body composition of overweight men and women. International journal of medical sciences. 2007 Jan;4(1):45-52

25. Udani J,Tan O,Molina J. Systematic Review and Meta-Analysis of a Proprietary Alpha-Amylase Inhibitor from White Bean (Phaseolus vulgaris L.) on Weight and Fat Loss in Humans. Foods (Basel, Switzerland). 2018 Apr;7(4)

26. DiNicolantonio J, Bhat A, J O. Effects of spirulina on weight loss and blood lipids: a review. Open Heart 2020;7:e001003.

27. Zeinalian R,Farhangi MA,Shariat A, et al. The effects of Spirulina Platensis on anthropometric indices, appetite, lipid profile and serum vascular endothelial growth factor (VEGF) in obese individuals: a randomized double blinded placebo controlled trial. BMC complementary and alternative medicine. 2017 Apr;17(1):225

28. Yousefi R,Mottaghi A,Saidpour A. Spirulina platensis effectively ameliorates anthropometric measurements and obesity-related metabolic disorders in obese or overweight healthy individuals: A randomized controlled trial. Complementary therapies in medicine. 2018 Oct;40:106-112

29. Hernández-Lepe MA,López-Díaz JA,Juárez-Oropeza MA, et al. Effect of Arthrospira (Spirulina) maxima Supplementation and a Systematic Physical Exercise Program on the Body Composition and Cardiorespiratory Fitness of Overweight or Obese Subjects: A Double-Blind, Randomized, and Crossover Controlled Trial. Marine drugs. 2018 Oct;16(10)

30. Moradi S,Ziaei R,Foshati S, et al. Effects of Spirulina supplementation on obesity: A systematic review and meta-analysis of randomized clinical trials. Complementary therapies in medicine. 2019 Dec;47:102211

31. Trivedi VR, Satia MC,Deschamps A, et al. Single-blind, placebo controlled randomised clinical study of chitosan for body weight reduction. Nutrition journal. 2016 Jan;15:3

32. Huang H, Liao D, Zou Y, et al. The effects of chitosan supplementation on body weight and body composition: a systematic review and meta-analysis of randomized controlled trials. Critical Reviews in Food Science and Nutrition. 2020 ;60(11):1815-1825

33. Moraru C, Mincea MM, Frandes M, et al. A Meta-Analysis on Randomised Controlled Clinical Trials Evaluating the Effect of the Dietary Supplement Chitosan on Weight Loss, Lipid Parameters and Blood Pressure. Medicina (Kaunas) 2018 Dec;54:109.

34. Jung EY, Jun SC, Chang UJ, et al. L-ascorbic acid addition to chitosan reduces body weight in overweight women. International journal for vitamin and nutrition research. Internationale Zeitschrift fur Vitamin- und Ernahrungsforschung. Journal International de Vitaminologie et de Nutrition. 2014 ;84(1-2):5-11

35. Gades MD, Stern JS. Chitosan supplementation and fat absorption in men and women. Journal of the American Dietetic Association. 2005 Jan;105(1):72-7

36. Gades MD, Stern JS. Chitosan supplementation and fecal fat excretion in men. Obes Res 2003;11:683-8.

37. Gades MD, Stern JS. Chitosan supplementation does not affect fat absorption in healthy males fed a high-fat diet, a pilot study. Int J Obes Relat Metab Disord 2002;26:119-22.

38. Guerciolini R, Radu-Radulescu L, Boldrin M, et al. Comparative evaluation of fecal fat excretion induced by orlistat and chitosan. Obes Res 2001;9:364-7.

39. Gao J, Azad MAK, Han H, et al. Impact of Prebiotics on Enteric Diseases and Oxidative Stress. Current Pharmaceutical Design. 2020;26(22):2630-2641

40. Maret W. Chromium Supplementation in Human Health, Metabolic Syndrome, and Diabetes. Met Ions Life Sci 2019;19.

41. Tsang C,Taghizadeh M,Aghabagheri E, et al. A meta-analysis of the effect of chromium supplementation on anthropometric indices of subjects with overweight or obesity. Clinical obesity. 2019 Aug;9(4):e12313

42. Tian H,Guo X,Wang X, et al. Chromium picolinate supplementation for overweight or obese adults. The Cochrane database of systematic reviews. 2013 Nov;11:CD010063

43. Onakpoya I,Posadzki P,Ernst E. Chromium supplementation in overweight and obesity: a systematic review and meta-analysis of randomized clinical trials. Obesity Reviews. 2013 Jun;14(6):496-507

44. Brownley KA, Von Holle A, Hamer RM, et al. A double-blind, randomized pilot trial of chromium picolinate for binge eating disorder: results of the Binge Eating and Chromium (BEACh) study. Journal of Psychosomatic Research. 2013 Jul;75(1):36-42.

45. de Melo Pereira GV, de Carvalho Neto DP, Magalhães Júnior AI, et al. Chemical composition and health properties of coffee and coffee by-products. Advances in Food and Nutrition Research. 2020;91:65-96

46. Tian T, Freeman S, Corey M, et al. Chemical characterization of potentially prebiotic oligosaccharides in brewed coffee and spent coffee grounds. Journal of Agricultural and Food Chemistry. 2017 Apr;65(13):2784-2792.

47. Mills CE, Tzounis X, Oruna-Concha MJ, et al. In vitro colonic metabolism of coffee and chlorogenic acid results in selective changes in human faecal microbiota growth. The British Journal of Nutrition. 2015 Apr;113(8):1220-7.

48. Poole R, Kennedy OJ, Roderick P, et al. Coffee consumption and health: umbrella review of meta-analyses of multiple health outcomes. BMJ (Clinical research ed.). 2017 11;359:j5024.

49. Gorji Z, Varkaneh HK, Talaei S, et al. The effect of green-coffee extract supplementation on obesity: A systematic review and dose-response meta-analysis of randomized controlled trials. Phytomedicine 2019 Oct;63:153018.

50. Asbaghi O, Sadeghian M, Rahmani S, et al. The effect of green coffee extract supplementation on anthropometric measures in adults: A comprehensive systematic review and dose-response meta-analysis of randomized clinical trials. Complementary Therapies in Medicine. 2020 Jun;51:102424.

51. Jovanovski E, Mazhar N, Komishon A, et al. Can dietary viscous fiber affect body weight independently of an energy-restrictive diet? A systematic review and meta-analysis of randomized controlled trials. The American Journal of Clinical Nutrition. 2020 02;111(2):471-485.

52. Namazi N, Larijani B, Azadbakht L. Are Isolated and Complex Fiber Supplements Good Choices for Weight Management? A Systematic Review. Archives of Iranian Medicine. 2017 Nov;20(11):704–713.

53. Van Hul M, Cani PD. Targeting Carbohydrates and Polyphenols for a Healthy Microbiome and Healthy Weight. Current Nutrition Reports. 2019 12;8(4):307–316.

54. Rothenberg DO, Zhou C, Zhang L. A Review on the Weight-Loss Effects of Oxidized Tea Polyphenols. Molecules (Basel, Switzerland). 2018 May;23(5).

55. Vázquez Cisneros LC, López-Uriarte P, López-Espinoza A, et al. Effects of green tea and its epigallocatechin (EGCG) content on body weight and fat mass in humans: a systematic review Nutricion Hospitalaria. 2017 06;34(3):731–737.

56. Jurgens TM, Whelan AM, Killian L, et al. Green tea for weight loss and weight maintenance in overweight or obese adults. The Cochrane Database of Systematic Reviews. 2012 Dec;12:CD008650.

57. Huang J, Wang Y, Xie Z, et al. The anti-obesity effects of green tea in human intervention and basic molecular studies. European Journal of Clinical Nutrition. 2014 Oct;68(10):1075–87.

58. Okla M, Kim J, Koehler K, et al. Dietary Factors Promoting Brown and Beige Fat Development and Thermogenesis. Advances in Nutrition (Bethesda, Md.). 2017 May;8(3):473–483.

59. Zhang JJ, Wu ZB, Cai YJ, et al. L-carnitine ameliorated fasting-induced fatigue, hunger, and metabolic abnormalities in patients with metabolic syndrome: a randomized controlled study. Nutrition Journal. 2014 Nov;13:110.

60. Zhang T, Zhang L, Ke B, et al. L-carnitine ameliorated weight loss in fasting therapy: A propensity score-matched study. Complementary Therapies in Medicine. 2019 Jun;44:162-165.

61. Askarpour M, Hadi A, Miraghajani M, et al. Beneficial effects of l-carnitine supplementation for weight management in overweight and obese adults: An updated systematic review and dose-response meta-analysis of randomized controlled trials. Pharmacological Research. 2020 01;151:104554.

62. Talenezhad N, Mohammadi M, Ramezani-Jolfaie N, et al. Effects of l-carnitine supplementation on weight loss and body composition: A systematic review and meta-analysis of 37 randomized controlled clinical trials with dose-response analysis. Clinical Nutrition ESPEN. 2020 06;37:9–23.

63. Pooyandjoo M, Nouhi M, Shab-Bihar S, et al. The effect of (L-)carnitine on weight loss in adults: a systematic review and meta-analysis of randomized controlled trials. Obes Rev 2016;17:970–6. doi:10.1111/obr.12436.

64. Samimi M, Jamilian M,Ebrahimi FA, et al. Oral carnitine supplementation reduces body weight and insulin resistance in women with polycystic ovary syndrome: a randomized, double-blind, placebo-controlled trial. Clinical Endocrinology. 2016 Jun;84(6):851–7.

65. Pi-Sunyer FX. "Obesity." In Shils ME, Olson JA, Shike M, Ross AC, eds. Modern Nutrition in Health and Disease, 9th ed. Baltimore: Williams and Wilkins, 1999,1410.

66. Jane M, McKay J, Pal S. Effects of daily consumption of psyllium, oat bran and polyGlycopleX on obesity-related disease risk factors: A critical review. Nutrition (Burbank, Los Angeles County, Calif.). 2019 01;57:84–91.

67. Reimer RA, Wharton S, Green TJ, et al. Effect of a functional fibre supplement on glycemic control when added to a year-long medically supervised weight management program in adults with type 2 diabetes. European Journal of Nutrition. 2020 Jul.

68. Solah VA, Kerr DA, Hunt WJ, et al. Effect of Fibre Supplementation on Body Weight and  Composition, Frequency of Eating and Dietary Choice in Overweight Individuals. Nutrients. 2017 02;9:149.

69. Pal S, Ho S, Gahler RJ, et al. Effect on body weight and composition in overweight/obese Australian adults over 12 months consumption of two different types of fibre supplementation in a randomized trial. Nutrition & metabolism. 2016;13:82.

70. Kacinik V, Lyon M, Purnama M, et al. Effect of PGX, a novel functional fibre supplement, on subjective ratings of appetite in overweight and obese women consuming a 3-day structured, low-calorie diet. Nutrition & Diabetes. 2011 Dec;1:e22.

71. Wang ZB, Xin SS, Ding LN, et al. The Potential Role of Probiotics in Controlling Overweight/Obesity and Associated Metabolic Parameters in Adults: A Systematic Review and Meta-Analysis. Evid Based Complement Alternat Med: eCAM. 2019;2019:3862971.

72. Sivamaruthi BS, Kesika P, Suganthy N, et al. A Review on Role of Microbiome in Obesity and Antiobesity Properties of Probiotic Supplements. Biomed Res Int. 2019;2019:3291367.

73. Mazloom K, Siddiqi I, Covasa M. Probiotics: How Effective Are They in the Fight against Obesity? Nutrients. 2019 Jan;11(2).

74. Cerdó T, García-Santos JA, G Bermúdez M, et al. The Role of Probiotics and Prebiotics in the Prevention and Treatment of Obesity. Nutrients. 2019 Mar;11(3).

75. Borgeraas H, Johnson LK, Skattebu J, et al. Effects of probiotics on body weight, body mass index, fat mass and fat percentage in subjects with overweight or obesity: a systematic review and meta-analysis of randomized controlled trials. Obesity Reviews 2018 02;19(2):219–232.

76. Aoun A,Darwish F, Hamod N. The Influence of the Gut Microbiome on Obesity in Adults and the Role of Probiotics, Prebiotics, and Synbiotics for Weight Loss. Prev Nutr Food Sci 2020 Jun;25(2):113–123.

77. Bhathena SJ, Velasquez MT. Beneficial role of dietary phytoestrogens in obesity and diabetes. Am J Clin Nutr 2002;76:1191-201 [review].

78. Allison DB, Gadbury G, Schwartz LG, et al. A novel soy-based meal replacement formula for weight loss among obese individuals: a randomized controlled clinical trial. Eur J Clin Nutr 2003;57:514-22.

79. Bosello O, Cominancini L, Zocca I, et al. Short- and long-term effects of hypocaloric diets containing proteins of different sources on plasma lipids and apoproteins of obese subjects. Ann Nutr Metab 1988; 32:206-14.

80. Yamashita T, Sasahara T, Pomeroy SE, et al. Arterial compliance, blood pressure, plasma leptin, and plasma lipids in women are improved with weight reduction equally with a meat-based diet and a plant-based diet. Metabolism 1998;47:1308-14.

81. Jenkins DJ, Wolever TM, Spiller G, et al. Hypocholesterolemic effect of vegetable protein in a hypocaloric diet. Atherosclerosis 1989;78:99-107.

82. Hyppönen E, Boucher BJ. Adiposity, vitamin D requirements, and clinical implications for obesity-related metabolic abnormalities. Nutr Rev 2018 09;76(9):678–692.

83. Slusher AL, McAllister MJ, Huang CJ. A therapeutic role for vitamin D on obesity-associated inflammation and weight-loss intervention. Inflamm Res 2015 Aug;64(8):565–75.

84. Lotfi-Dizaji L, Mahboob S, Aliashrafi S, et al. Effect of vitamin D supplementation along with weight loss diet on meta-inflammation and fat mass in obese subjects with vitamin D deficiency: A double-blind placebo-controlled randomized clinical trial. Clin Endocrinol (Oxf) 2019 01;90(1):94–101.

85. Abboud M, Liu X, Fayet-Moore F, et al. Effects of Vitamin D Status and Supplements on Anthropometric and Biochemical Indices in a Clinical Setting: A Retrospective Study. Nutrients 2019 Dec;11(12):3032.

86. Mason C, Xiao L, Imayama I, et al. Vitamin D3 supplementation during weight loss: a double-blind randomized controlled trial. Am J Clin Nutr 2014 May;99(5):1015–25.

87. Devries MC, Phillips SM. Supplemental protein in support of muscle mass and health: advantage whey. J Food Sci 2015 Mar;80 Suppl 1:A8–A15.

88. Bendtsen LQ, Lorenzen JK, Bendsen NT, et al. Effect of dairy proteins on appetite, energy expenditure, body weight, and composition: a review of the evidence from controlled clinical trials. Adv Nutr 2013 Jul;4(4):418–38.

89. Pal S, Radavelli-Bagatini S. The effects of whey protein on cardiometabolic risk factors. Obes Rev 2013 Apr;14(4):324–43.

90. Jakubowicz D, Wainstein J, Landau Z, et al. High-energy breakfast based on whey protein reduces body weight, postprandial glycemia and HbA1C in Type 2 diabetes. J Nutr Biochem 2017 11;49:1–7.

91. Wirunsawanya K, Upala S, Jaruvongvanich V, et al. Whey Protein Supplementation Improves Body Composition and Cardiovascular Risk Factors in Overweight and Obese Patients: A Systematic Review and Meta-Analysis. J Am Coll Nutr 2018 01;37(1):60–70.

92. Sedláčková B, Dušátková L, Zamrazilová H, et al. 7-oxygenated derivatives of dehydroepiandrosterone and obesity. Prague Med Rep 2012 ;113(2):147–55.

93. Schirmer MA, Phinney SD. Gamma-linolenate reduces weight regain in formerly obese humans. J Nutr 2007;137:1430-35.

94. Schirmer MA, Phinney SD. Gamma-linolenate reduces weight regain in formerly obese humans. J Nutr 2007;137:1430-35.

95. Navarro-Herrera D, Aranaz P, Eder-Azanza L, et al. Borago officinalis seed oil (BSO), a natural source of omega-6 fatty acids, attenuates fat accumulation by activating peroxisomal beta-oxidation both in C. elegans and in diet-induced obese rats. Food Funct 2018 Aug;9(8):4340–51.

96. Kerksick CM, Roberts MD, Campbell BI, et al. Differential Impact of Calcium and Vitamin D on Body Composition Changes in Post-Menopausal Women Following a Restricted Energy Diet and Exercise Program. Nutrients 2020 Mar;12(3).

97. Ilich JZ, Kelly OJ, Liu PY, et al. Role of Calcium and Low-Fat Dairy Foods in Weight-Loss Outcomes Revisited: Results from the Randomized Trial of Effects on Bone and Body Composition in Overweight/Obese Postmenopausal Women. Nutrients 2019 May;11(5).

98. Subih HS, Zueter Z, Obeidat BM, et al. A high weekly dose of cholecalciferol and calcium supplement enhances weight loss and improves health biomarkers in obese women.Nutr Res 2018 11;59:53–64.

99. Bendtsen LQ, Lorenzen JK, Bendsen NT, et al. Effect of dairy proteins on appetite, energy expenditure, body weight, and composition: a review of the evidence from controlled clinical trials. Adv Nutr 2013 Jul;4(4):418–38.

100. Madsen L, Myrmel LS, Fjære E, et al. Dietary Proteins, Brown Fat, and Adiposity. Front Physiol. 2018 ;9:1792.

101. Madzima TA, Panton LB, Fretti SK, et al. Night-time consumption of protein or carbohydrate results in increased morning resting energy expenditure in active college-aged men. Br J Nutr  2014 Jan;111(1):71–7.

102. Madzima TA, Melanson JT, Black JR, et al. Pre-Sleep Consumption of Casein and Whey Protein: Effects on Morning Metabolism and Resistance Exercise Performance in Active Women. Nutrients 2018 Sep;10(9).

103. Kinsey AW, Cappadona SR, Panton LB, et al. The Effect of Casein Protein Prior to Sleep on Fat Metabolism in Obese Men. Nutrients 2016 Jul;8(8).

104. Bendtsen LQ, Lorenzen JK, Gomes S, et al. Effects of hydrolysed casein, intact casein and intact whey protein on energy expenditure and appetite regulation: a randomised, controlled, cross-over study. Br J Nutr 2014 Oct;112(8):1412–22.

105. Anderson JW, Fuller J, Patterson K, et al. Soy compared with casein meal replacement shakes with energy-restricted diets for obese women: randomized controlled trial. Metabolism 2007;56:280–8.

106. Adechian S, Balage M, Remond D, et al. Protein feeding pattern, casein feeding, or milk-soluble protein feeding did not change the evolution of body composition during a short-term weight loss program. Am J Physiol Endocrinol Metab 2012 Oct;303(8):E973–82.

107. Bosello O, Cominancini L, Zocca I, et al. Short- and long-term effects of hypocaloric diets containing proteins of different sources on plasma lipids and apoproteins of obese subjects. Ann Nutr Metab 1988; 32:206-14.

108. Sanati S, Razavi BM, Hosseinzadeh H. A review of the effects of Capsicum annuum L. and its constituent, capsaicin, in metabolic syndrome. Iran J Basic Med Sci  2018 May;21(5):439–448.

109. Rigamonti AE, Casnici C, Marelli O, et al. Acute administration of capsaicin increases resting energy expenditure in young obese subjects without affecting energy intake, appetite, and circulating levels of orexigenic/anorexigenic peptides. Nutr Res 2018 04;52:71–79.

110. Snitker S, Fujishima Y, Shen H, et al. Effects of novel capsinoid treatment on fatness and energy metabolism in humans: possible pharmacogenetic implications. Am J Clin Nutr 2009 Jan;89(1):45–50.

111. Inoue N, Matsunaga Y, Satoh H, et al. Enhanced energy expenditure and fat oxidation in humans with high BMI scores by the ingestion of novel and non-pungent capsaicin analogues (capsinoids). Biosci Biotechnol Biochem 2007 Feb;71(2):380–9.

112. Lejeune MP, Kovacs EM, Westerterp-Plantenga MS. Effect of capsaicin on substrate oxidation and weight maintenance after modest body-weight loss in human subjects. Br J Nutr 2003 Sep;90(3):651–59.

113. Sun L, Camps SG, Goh HJ, et al. Capsinoids activate brown adipose tissue (BAT) with increased energy expenditure associated with subthreshold 18-fluorine fluorodeoxyglucose uptake in BAT-positive humans confirmed by positron emission tomography scan. Am J Clin Nutr 2018 01;107(1):62–70.

114. Coleus forskohlii. Monograph. Altern Med Rev 2006 Mar;11(1):47–51.

115. Chiadak JD, Arsenijevic T, Verstrepen K, et al. Forskolin Inhibits Lipopolysaccharide-Induced Modulation of MCP-1 and GPR120 in 3T3-L1 Adipocytes through an Inhibition of NFκB. Mediators Inflamm 2016;2016:1431789.

116. Badmaev V, Majeed M, Conte A, Parker J. Diterpene Forskolin (Coleus forskohlii, Benth.): A possible new compound for reduction of body weight by increasing lean body mass. NutraCos - Nutraceuticals 2002;1:6–7.

117. Henderson S, Magu B, Rasmussen C, et al. Effects of coleus forskohlii supplementation on body composition and hematological profiles in mildly overweight women. J Int Soc Sports Nutr 2005 Dec;2:54–62.

118. Loftus HL, Astell KJ, Mathai ML, et al. Coleus forskohlii Extract Supplementation in Conjunction with a Hypocaloric Diet Reduces the Risk Factors of Metabolic Syndrome in Overweight and Obese Subjects: A Randomized Controlled Trial. Nutrients 2015 Nov;7(11):9508–22.

119. Whigham LD, Watras AC, Schoeller DA. Efficacy of conjugated linoleic acid for reducing fat mass: a meta-analysis in humans. Am J Clin Nutr 2007;85:1203–11.

120. den Hartigh LJ. Conjugated Linoleic Acid Effects on Cancer, Obesity, and Atherosclerosis: A Review of Pre-Clinical and Human Trials with Current Perspectives. Nutrients 2019 Feb;11(2):370.

121. Onakpoya IJ, Posadzki PP, Watson LK, et al. The efficacy of long-term conjugated linoleic acid (CLA) supplementation on body composition in overweight and obese individuals: a systematic review and meta-analysis of randomized clinical trials. Eur J Nutr 2012 Mar;51(2):127–34.

122. Larsen TM, Toubro S, Gudmundsen O, et al. Conjugated linoleic acid supplementation for 1 y does not prevent weight or body fat regain. Am J Clin Nutr 2006 Mar;83(3):606–12.

123. Ebrahimi-Mameghani M, Jamali H, Mahdavi R, et al. Conjugated linoleic acid improves glycemic response, lipid profile, and oxidative stress in obese patients with non-alcoholic fatty liver disease: a randomized controlled clinical trial. Croat Med J 2016 Aug;57(4):331–42.

124. Riserus U, Vessby B, Arnlov J, Basu S. Effects of cis-9,trans-11 conjugated linoleic acid supplementation on insulin sensitivity, lipid peroxidation, and proinflammatory markers in obese men. Am J Clin Nutr 2004;80:279–83.

125. Risérus U, Vessby B, Arner P, et al. Supplementation with trans10cis12-conjugated linoleic acid induces hyperproinsulinaemia in obese men: close association with impaired insulin sensitivity. Diabetologia 2004 Jun;47(6):1016–9.

126. Vihma V, Heinonen S, Naukkarinen J, et al. Increased body fat mass and androgen metabolism - A twin study in healthy young women. Steroids 2018 12;140:24–31.

127. Aoki K, Terauchi Y. Effect of Dehydroepiandrosterone (DHEA) on Diabetes Mellitus and Obesity. Vitam Horm 2018;108:355–65.

128. Gómez-Santos C, Hernández-Morante JJ, Tébar FJ, et al. Differential effect of oral dehydroepiandrosterone-sulphate on metabolic syndrome features in pre- and postmenopausal obese women. Clin Endocrinol (Oxf) 2012 Oct;77(4):548–54.

129. Weiss EP, Villareal DT, Fontana L, et al. Dehydroepiandrosterone (DHEA) replacement decreases insulin resistance and lowers inflammatory cytokines in aging humans. Aging (Albany NY) 2011 May;3(5):533–42.

130. Villareal DT, Holloszy JO. Effect of DHEA on abdominal fat and insulin action in elderly women and men: a randomized controlled trial. JAMA 2004 Nov;292(18):2243–8.

131. Kalupahana NS, Claycombe KJ, Moustaid-Moussa N. (n-3) Fatty acids alleviate adipose tissue inflammation and insulin resistance: mechanistic insights. Adv Nutr 2011 Jul;2(4):304–16.

132. Albracht-Schulte K, Kalupahana NS, Ramalingam L, et al. Omega-3 fatty acids in obesity and metabolic syndrome: a mechanistic update. J Nutr Biochem 2018 08;58:1–16.

133. Keshavarz SA, Mostafavi SA, Akhondzadeh S, et al. Omega-3 supplementation effects on body weight and depression among dieter women with co-morbidity of depression and obesity compared with the placebo: A randomized clinical trial. Clin Nutr ESPEN 2018 06;25:37–43.

134. Zhang YY, Liu W, Zhao TY, et al. Efficacy of Omega-3 Polyunsaturated Fatty Acids Supplementation in Managing Overweight and Obesity: A Meta-Analysis of Randomized Clinical Trials. J Nutr Health Aging 2017;21(2):187–92.

135. Wan-Loy C, Siew-Moi P. Marine Algae as a Potential Source for Anti-Obesity Agents. Mar Drugs 2016 Dec;14(12):222.

136. Abidov M, Ramazanov Z, Seifulla R, et al. The effects of Xanthigen in the weight management of obese premenopausal women with non-alcoholic fatty liver disease and normal liver fat. Diabetes Obes Metab 2010 Jan;12(1):72–81.

137. Kim KM, Kim SM, Cho DY, et al. The Effect of Xanthigen on the Expression of Brown Adipose Tissue Assessed by ¹⁸F-FDG PET. Yonsei Med J 2016 Jul;57(4):1038–41.

138. Lowenstein JM. Effect of (-)-hydroxycitrate on fatty acid synthesis by rat liver in vivo. J Biol Chem 1971;246:629-32.

139. Triscari J, Sullivan AC. Comparative effects of (-)-hydroxycitrate and (+)-allo-hydroxycitrate on acetyl CoA carboxylase and fatty acid and cholesterol synthesis in vivo. Lipids 1977;12:357-63.

140. Cheema-Dhadli S, Harlperin ML, Leznoff CC. Inhibition of enzymes which interact with citrate by (-)hydroxycitrate and 1,2,3,-tricarboxybenzene. Eur J Biochem 1973;38:98-102.

141. Sullivan AC, Hamilton JG, Miller ON, et al. Inhibition of lipogenesis in rat liver by (-)-hydroxycitrate. Arch Biochem Biophys 1972;150:183-90.

142. Greenwood MRC, Cleary MP, Gruen R, et al. Effect of (-)-hydroxycitrate on development of obesity in the Zucker obese rat. Am J Physiol 1981;240:E72-8.

143. Sullivan AC, Triscari J. Metabolic regulation as a control for lipid disorders. Am J Clin Nutr 1977;30:767-76.

144. Sullivan AC, Triscari J, Hamilton JG, et al. Effect of (-)-hydroxycitrate upon the accumulation of lipid in the rat: I. Lipogenesis. Lipids 1974;9:121-8.

145. Sullivan AC, Triscari J, Hamilton JG, et al. Effect of(-)-hydroxycitrate upon the accumulation of lipid in the rat: II. Appetite. Lipids1974;9:129-34.

146. Heymsfield SB, Allison DB, Vasselli JR, et al. Garcinia cambogia (hydroxycitricacid) as a potential antiobesity agent: a randomized controlled trial. JAMA1998;280:1596-600.

147. Martinet A, Hostettmann K, Schultz Y. Thermogenic effects of commercially available plant preparations aimed at treating human obesity. Phytomedicine 1999;6:231-8.

148. Mattes RD, Bormann L. Effects of (-)-hydroxycitric acid on appetitive variables. Physiol Behav 2000;71:87-94.

149. Devaraj R, Reddy C, Xu B. Health-promoting effects of konjac glucomannan and its practical applications: A critical review. Int J Biol Macromol 2019;126:273–81.

150. Keithley J, Swanson B. Glucomannan and obesity: a critical review. Altern Ther Health Med 2005;11(6):30–4.

151. Walsh DE, Yaghoubian V, Behforooz A. Effect of glucomannan on obese patients: a clinical study. Int J Obes 1984;8:289-93.

152. Keithley JK, Swanson B, Mikolaitis SL, et al. Safety and efficacy of glucomannan for weight loss in overweight and moderately obese adults. J Obes 2013;2013:610908.

153. Onakpoya I, Posadzki P, Ernst E. The efficacy of glucomannan supplementation in overweight and obesity: a systematic review and meta-analysis of randomized clinical trials. J Am Coll Nutr 2014;33(1):70–8.

154. Galligan JJ. Beneficial actions of microbiota-derived tryptophan metabolites. Neurogastroenterol Motil 2018 02;30(2).

155. Namkung J, Kim H, Park S. Peripheral Serotonin: a New Player in Systemic Energy Homeostasis. Mol Cells 2015 Dec;38(12):1023–8.

156. Strasser B, Berger K, Fuchs D. Effects of a caloric restriction weight loss diet on tryptophan metabolism and inflammatory biomarkers in overweight adults. Eur J Nutr 2015 Feb;54(1):101–7.

157. Hrboticky N, Leiter L, Anderson G. Effects of L-tryptophan on short term food intake in lean men. Nutr Res 1985;5:595–607.

158. Cavaliere H, Medeiros-Neto G. The anorectic effect of increasing doses of L-tryptophan in obese patients. Eat Weight Disord 1997;2:211-5.

159. Strain GW, Strain JJ, Zumoff B. L-tryptophan does not increase weight loss in carbohydrate-craving obese subjects. Int J Obes 1985;9:375-80.

160. Stanko RT, Tietze DL, Arch JE. Body composition, energy utilization, and nitrogen metabolism with a 4.25-MJ/d low-energy diet supplemented with pyruvate. Am J Clin Nutr 1992;56:630-5.

161. Kalman D, Colker CM, Wilets I, et al. The effects of pyruvate supplementation on body composition in overweight individuals. Nutrition 1999;15:337-40.

162. Onakpoya I, Hunt K, Wider B, et al. Pyruvate supplementation for weight loss: a systematic review and meta-analysis of randomized clinical trials. Crit Rev Food Sci Nutr 2014;54(1):17–23.

163. Kucio C, Jonderko K, Piskorska D. Does yohimbine act as a slimming drug? Isr J Med Sci 1991;27:550–6.

164. Sax L. Yohimbine does not affect fat distribution in men. Int J Obes 1991;15:561-5.

165. Swann AC, Lijffijt M, Lane SD, et al. Norepinephrine and impulsivity: effects of acute yohimbine. Psychopharmacology (Berl) 2013 Sep;229(1):83–94.

166. Wang X, Li D, Liu F, et al. Dietary citrus and/or its extracts intake contributed to weight control: Evidence from a systematic review and meta-analysis of 13 randomized clinical trials. Phytother Res 2020 Aug;34(8):2006–2022.

167. Stohs SJ. Safety, Efficacy, and Mechanistic Studies Regarding Citrus aurantium (Bitter Orange) Extract and p-Synephrine. Phytother Res2017 Oct;31(10):1463–1474.

168. Gutiérrez-Hellín J, Del Coso J. Dose-Response Effects of p-Synephrine on Fat Oxidation Rate During Exercise of Increasing Intensity. Phytother Res 2018 Feb;32(2):370–4.

169. Gougeon R, Harrigan K, Tremblay JF, et al. Increase in the thermic effect of food in women by adrenergic amines extracted from citrus aurantium. Obes Res 2005 Jul;13(7):1187–94.

170. Arent SM, Walker AJ, Pellegrino JK, et al. The Combined Effects of Exercise, Diet, and a Multi-Ingredient Dietary Supplement on Body Composition and Adipokine Changes in Overweight Adults. J Am Coll Nutr 2018 02;37(2):111–120.

171. Colker CM, Kalman DS, Torina GC, et al. Effects of Citrus aurantium extract, caffeine, and St. John's wort on body fat, lipid levels, and mood states in overweight adults. Curr Ther Res 1999;60:145-53.

172. Bent S, Padula A, Neuhaus J. Safety and efficacy of citrus aurantium for weight loss. Am J Cardiol 2004 Nov;94(10):1359–61.

173. Bui LT, Nguyen DT, Ambrose PJ. Blood pressure and heart rate effects following a single dose of bitter orange. Ann Pharmacother 2006 Jan;40(1):53–7.

174. Haller CA, Benowitz NL, Jacob P. Hemodynamic effects of ephedra-free weight-loss supplements in humans. Am J Med 2005 Sep;118(9):998–1003.

175. Stohs SJ, Preuss HG, Shara M. A review of the human clinical studies involving Citrus aurantium (bitter orange) extract and its primary protoalkaloid p-synephrine. Int J Med Sci 2012 ;9(7):527–38.

176. Butt MS, Shahzadi N, Sharif MK, et al. Guar gum: a miracle therapy for hypercholesterolemia, hyperglycemia and obesity. Crit Rev Food Sci Nutr. 2007;47(4):389–96.

177. Pittler MH, Ernst E. Guar gum for body weight reduction: meta-analysis of randomized trials. Am J Med 2001 Jun;110(9):724–30.

178. Bortolin RC, Vargas AR, de Miranda Ramos V, et al. Guarana supplementation attenuated obesity, insulin resistance, and adipokines dysregulation induced by a standardized human Western diet via brown adipose tissue activation. Phytother Res 2019 May;33(5):1394–403.

179. Lima NDS, Teixeira L, Gambero A, et al. Guarana (Paullinia cupana) Stimulates Mitochondrial Biogenesis in Mice Fed High-Fat Diet. Nutrients 2018 Jan;10(2):165.

180. Boozer CN, Nasser JA, Heymsfield SB, et al. An herbal supplement containing Ma Huang-Guarana for weight loss: a randomized, double-blind trial. Int J Obes Relat Metab Disord 2001 Mar;25(3):316–24.

181. Ahmad MA, Mujeeb M, Akhtar M, et al. Guggulipid: A Promising Multi-Purpose Herbal Medicinal Agent. Drug Res (Stuttg) 2020 Apr;70(4):123–30.

182. Miller CN, Samuels JS, Azhar Y, et al. Guggulsterone Activates Adipocyte Beiging through Direct Effects on 3T3-L1 Adipocytes and Indirect Effects Mediated through RAW264.7 Macrophages. Medicines (Basel) 2019 Jan;6(1):22.

183. Ulbricht C, Basch E, Szapary P, et al. Guggul for hyperlipidemia: a review by the Natural Standard Research Collaboration. Complement Ther Med 2005;Dec;13(4):279–90.

184. Patti AM, Al-Rasadi K, Katsiki N, et al. Effect of a Natural Supplement Containing Curcuma Longa, Guggul, and Chlorogenic Acid in Patients With Metabolic Syndrome. Angiology 2015;Oct;66(9):856–61.

185. Lonnie M, Laurie I, Myers M, et al. Exploring Health-Promoting Attributes of Plant Proteins as a Functional Ingredient for the Food Sector: A Systematic Review of Human Interventional Studies. Nutrients 2020 Jul;12(8):E2291.

186. Farinon B, Molinari R, Costantini L, et al. The seed of industrial hemp (Cannabis sativa L.): Nutritional Quality and Potential Functionality for Human Health and Nutrition. Nutrients 2020 Jun;12(7):E1935.

187. Blom WA, Abrahamse SL, Bradford R, et al. Effects of 15-d repeated consumption of Hoodia gordonii purified extract on safety, ad libitum energy intake, and body weight in healthy, overweight women: a randomized controlled trial. Am J Clin Nutr 2011;94:1171-81.

188. Landor M, Benami A, Segev N, et al. Efficacy and acceptance of a commercial Hoodia parviflora product for support of appetite and weight control in a consumer trial. J Med Food 2015 Feb;18(2):250–8.

189. Lonnie M, Laurie I, Myers M, et al. Exploring Health-Promoting Attributes of Plant Proteins as a Functional Ingredient for the Food Sector: A Systematic Review of Human Interventional Studies. Nutrients 2020 Jul;12(8):E2291.

190. Hawley AL, Gbur E, Tacinelli AM, et al. The Short-Term Effect of Whey Compared with Pea Protein on Appetite, Food Intake, and Energy Expenditure in Young and Older Men. Curr Dev Nutr 2020 Feb;4(2):nzaa009.

191. Dougkas A, Östman E. Comparable effects of breakfast meals varying in protein source on appetite and subsequent energy intake in healthy males. Eur J Nutr 2018 Apr;57(3):1097–1108.

192. Nielsen LV, Kristensen MD, Klingenberg L, et al. Protein from Meat or Vegetable Sources in Meals Matched for Fiber Content has Similar Effects on Subjective Appetite Sensations and Energy Intake-A Randomized Acute Cross-Over Meal Test Study. Nutrients 2018 Jan;10(1):96.

193. Diepvens K, Haberer D, Westerterp-Plantenga M. Different proteins and biopeptides differently affect satiety and anorexigenic/orexigenic hormones in healthy humans. Int J Obes 2008;32:510-8. doi: 10.1038/sj.ijo.0803758. Epub 2007 Nov 27.

194. Talbott SM, Talbott JA, Pugh M. Effect of Magnolia officinalis and Phellodendron amurense (Relora®) on cortisol and psychological mood state in moderately stressed subjects. J Int Soc Sports Nutr 2013 Aug;10(1):37.

195. Garrison R, Chambliss WG. Effect of a proprietary Magnolia and Phellodendron extract on weight management: a pilot, double-blind, placebo-controlled clinical trial. Altern Ther Health Med 2006;12(1):50–4.

196. Lonnie M, Laurie I, Myers M, et al. Exploring Health-Promoting Attributes of Plant Proteins as a Functional Ingredient for the Food Sector: A Systematic Review of Human Interventional Studies. Nutrients 2020 Jul;12(8):E2291.

197. Yang L, Chen JH, Lv J, et al. Rice protein improves adiposity, body weight and reduces lipids level in rats through modification of triglyceride metabolism. Lipids Health Dis 2012 Feb;11:24.

198. Hong L, Yi W, Liangliang C, et al. Hypoglycaemic and hypolipidaemic activities of sesamin from sesame meal and its ability to ameliorate insulin resistance in KK-Ay mice. J Sci Food Agric 2013 Jun;93(8):1833–8.

199. Takada S, Kinugawa S, Matsushima S, et al. Sesamin prevents decline in exercise capacity and impairment of skeletal muscle mitochondrial function in mice with high-fat diet-induced diabetes. Exp Physiol 2015 Nov;100(11):1319–30.

200. Imai A, Oda Y, Ito N, et al. Effects of Dietary Supplementation of Astaxanthin and Sesamin on Daily Fatigue: A Randomized, Double-Blind, Placebo-Controlled, Two-Way Crossover Study. Nutrients 2018 Feb;10(3):281.

201. Takemoto D, Yasutake Y, Tomimori N, et al. Sesame Lignans and Vitamin E Supplementation Improve Subjective Statuses and Anti-Oxidative Capacity in Healthy Humans With Feelings of Daily Fatigue. Glob J Health Sci 2015 Mar;7(6):1–10.

202. Helli B, Mowla K, Mohammadshahi M, et al. Effect of Sesamin Supplementation on Cardiovascular Risk Factors in Women with Rheumatoid Arthritis. J Am Coll Nutr 2016;35(4):300–7.

203. Burton-Freeman B. Dietary fiber and energy regulation. J Nutr 2000;130(2S Suppl):272S-275S [review].

204. Saltzman E, Roberts SB. Soluble fiber and energy regulation. Current knowledge and future directions. Adv Exp Med Biol 1997;427:89-97 [review].

205. Howarth NC, Saltzman E, Roberts SB. Dietary fiber and weight regulation. Nutr Rev 2001;59:129-39 [review].

206. Ball SD, Keller KR, Moyer-Mileur LJ, et al. Prolongation of satiety after low versus moderately high glycemic index meals in obese adolescents. Pediatrics 2003;111:488-94.

207. Dumesnil JG, Turgeon J, Tremblay A, et al. Effect of a low-glycaemic index-low-fat-high protein diet on the atherogenic metabolic risk profile of abdominally obese men. Br J Nutr 2001;86:557-68.

208. Roberts SB. High-glycemic index foods, hunger, and obesity: is there a connection? Nutr Rev 2000;58:163-9 [review].

209. Raben A. Should obese patients be counselled to follow a low glycaemic diet? No. Obesity Rev 2002;3:245-56 [review].

210. Slabber M, Barnard HC, Kuyl JM, et al. Effects of a low-insulin-response, energy-restricted diet on weight loss and plasma insulin concentrations in hyperinsulinemic obese females. Am J Clin Nutr 1994;60:48-53.

211. Spieth LE, Harnish JD, Lenders CM, et al. A low-glycemic index diet in the treatment of pediatric obesity. Arch Pediatr Adolesc Med 2000;154:947-51.

212. Armstrong J, Reilly JJ, Child Health Information Team. Breastfeeding and lowering the risk of childhood obesity. Lancet 2002;359:2003-4.

213. Westman EC, Yancy WS, Edman JS, et al. Effect of 6-month adherence to a very low carbohydrate diet program. Am J Med 2002;113:30-6.

214. Bravata DM, Sanders L, Huang J, et al. Efficacy and safety of low-carbohydrate diets: a systematic review. JAMA 2003;289:1837-50 [review].

215. Foster GD, Wyatt HR, Hill JO, et al. A randomized trial of a low-carbohydrate diet for obesity. N Engl J Med 2003;348:2082-90.

216. Samaha FF, Iqbal N, Seshadri P, et al. A low-carbohydrate as compared with a low-fat diet in severe obesity. N Engl J Med 2003;348:2074-81.

217. Brehm BJ, Seeley RJ, Daniels SR, D'Alessio DA. A randomized trial comparing a very low carbohydrate diet and a calorie-restricted low fat diet on body weight and cardiovascular risk factors in healthy women. J Clin Endocrinol Metab 2003;88:1617-23.

218. Sondike SB, Copperman N, Jacobson MS. Effects of a low-carbohydrate diet on weight loss and cardiovascular risk factor in overweight adolescents. J Pediatr 2003;142:253-8.

219. Fleming RM. The effect of high-, moderate-, and low-fat diets on weight loss and cardiovascular disease risk factors. Prev Cardiol 2002;5:110-8.

220. Fleming RM. The effect of high-protein diets on coronary blood flow. Angiology 2000;51:817-26.

221. Eisenstein J, Roberts SB, Dallal G, Saltzman E. High-protein weight-loss diets: are they safe and do they work? A review of the experimental and epidemiologic data. Nutr Rev 2002;60:189-200 [review].

222. Layman DK, Boileau RA, Erickson DJ, et al. A reduced ratio of dietary carbohydrate to protein improves body composition and blood lipid profiles during weight loss in adult women. J Nutr 2003;133:411-7.

223. Skov AR, Toubro S, Ronn B, et al. Randomized trial on protein vs carbohydrate in ad libitum fat reduced diet for the treatment of obesity. Int J Obes Relat Metab Disord 1999;23:528-36.

224. Miller WC. How effective are traditional dietary and exercise interventions for weight loss? Med Sci Sports Exerc 1999;31:1129-34 [review].

225. Kassirer JP, Angell M. Losing weight—an ill-fated New Year's resolution. N Engl J Med 1998;338:52-4.

226. National Heart, Lung, and Blood Institute. Clinical Guidelines on the Identification, Evaluation, and Treatment of Overweight and Obesity in Adults: The Evidence Report. NIH Publication No. 98-4083. Washington DC: National Institutes of Health, 1998.

227. Astrup A, Grunwald GK, Melanson EL, et al. The role of low-fat diets in body weight control: a meta-analysis of ad libitum dietary intervention studies. Int J Obes Relat Metab Disord 2000;24:1545-52 [review].

228. Pirozzo S, Summerbell C, Cameron C, Glasziou P. Advice on low-fat diets for obesity. Cochrane Database Syst Rev 2002;(2):CD003640 [review].

229. Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults. Executive Summary of The Third Report of The National Cholesterol Education Program (NCEP) Expert Panel on Detection, Evaluation, And Treatment of High Blood Cholesterol In Adults (Adult Treatment Panel III). JAMA 2001;285:2486-97.

230. Potter J, ed. World Cancer Research Fund in association with American Institute for Cancer Research. Food, Nutrition and the Prevention of Cancer: A Global Perspective. Washington, DC: American Institute for Cancer Research; 1997.

231. Andersson I, Lennernas M, Rossner S. Meal pattern and risk factor evaluation in one-year completers of a weight reduction program for obese men—the study. J Intern Med 2000;247:30-8.

232. Shick SM, Wing RR, Klem ML, et al. Persons successful at long-term weight loss and maintenance continue to consume a low-energy, low-fat diet. J Am Diet Assoc 1998;98:408-13.

233. Wyatt HR, Grunwald GK, Mosca CL, et al. Long-term weight loss and breakfast in subjects in the National Weight Control Registry. Obes Res 2002;10:78-82.

234. Muls E, Kempen K, Vansant G, Saris W. Is weight cycling detrimental to health? A review of the literature in humans. Int J Obes Relat Metab Disord 1995;19 Suppl 3:S46-S50 [review].

235. Randolph TG. Masked food allergy as a factor in the development and persistence of obesity. J Lab Clin Med 1947;32:1547.

236. Wadden TA, Berkowitz RI, Sarwer DB, et al. Benefits of lifestyle modification in the pharmacologic treatment of obesity. A randomized trial. Arch Intern Med 2001;161:218-27.

237. Votruba SB, Horvitz MA, Schoeller DA. The role of exercise in the treatment of obesity. Nutrition 2000;16:179-88.

238. Miller WC, Koceja DM, Hamilton EJ. A meta-analysis of the past 25 years of weight-loss research using diet, exercise or diet plus exercise intervention. Int J Obes Relat Metab Disord 1997;21:941-7.

239. Pritchard JE, Nowson CA, Wark JD. A worksite program for overweight middle-aged men achieves lesser weight loss with exercise than with dietary change. J Am Diet Assoc 1997 Jan;97:37-42.

240. Pavlou KN, Krey S, Steffee WP. Exercise as an adjunct to weight loss and maintenance in moderately obese subjects. Am J Clin Nutr 1989;49(5 Suppl):1115-23.

241. Wing RR, Hill JO. Successful weight-loss maintenance. Annu Rev Nutr 2001;21:323-41.

242. Racette SB, Schoeller DA, Kushner RF, Neil KM. Exercise enhances dietary compliance during moderate energy restriction in obese women. Am J Clin Nutr 1995;62:345-9.

243. Cummings S, Parham ES, Strain GW; American Dietetic Association. Position of the American Dietetic Association: weight management. J Am Diet Assoc 2002 Aug;102:114–55.

244. Jakicic JM, Clark K, Coleman E, et al. American College of Sports Medicine position stand. Appropriate intervention strategies for weight loss and prevention of weight regain for adults. Med Sci Sports Exerc 2001;33:2145-56 [review].

245. Riebe D, Greene GW, Ruggiero L, et al. Evaluation of a healthy-lifestyle approach to weight management. Prev Med 2003;36:45-54.

246. National Task Force on the Prevention and Treatment of Obesity. Dieting and the Development of Eating Disorders in Overweight and Obese Adults. Arch Intern Med 2000;160:2581-9.

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The information presented by TraceGains is for informational purposes only. It is based on scientific studies (human, animal, or in vitro), clinical experience, or traditional usage as cited in each article. The results reported may not necessarily occur in all individuals. Self-treatment is not recommended for life-threatening conditions that require medical treatment under a doctor's care. For many of the conditions discussed, treatment with prescription or over the counter medication is also available. Consult your doctor, practitioner, and/or pharmacist for any health problem and before using any supplements or before making any changes in prescribed medications. Information expires December 2024.

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