Type 1 Diabetes

Health Condition

Type 1 Diabetes

  • Alpha-Lipoic Acid

    Supplementing with alpha-lipoic acid may improve the symptoms of diabetic nerve damage (neuropathy).

    Dose:

    600 to 1,200 mg daily
    Alpha-Lipoic Acid
    ×
    Alpha lipoic acid is an important nutrient for mitochondrial function. It has antioxidant properties and can act as a reducer of oxidized forms of vitamins C and E. A number of placebo-controlled clinical trials have found that supplementing with 600 to 1,200 mg of alpha-lipoic acid per day can improve the symptoms of diabetic nerve damage (neuropathy).5,6,7,8 Animal studies and early clinical research suggest alpha-lipoic acid may also help prevent diabetes-related damage to the small blood vessels and nerves in the eyes (diabetic retinopathy).9,10

  • Magnesium

    People with type 1 diabetes tend to have low magnesium levels and supplementing with magnesium may reduce the risk of deficiency-related problems, such as eye damage and neuropathy.

    Dose:

    200 to 600 mg daily
    Magnesium
    ×
    People with type 1 diabetes often have low magnesium levels, and low magnesium status is correlated with poor glucose control and increased risk of complications. In magnesium-deficient pregnant women with type 1 diabetes, the lack of magnesium may even account for the high rate of miscarriages and birth defects associated with type 1 diabetes. Some studies have found that magnesium replenishment using supplements can improve blood glucose control and may reduce the risks of certain diabetes complications, such as cardiovascular disease and neuropathy, in children and adults with type 1 diabetes. Many doctors recommend that adults with type 1 diabetes and normal kidney function supplement with 200 to 600 mg of magnesium per day to maintain normal magnesium status; children with type 1 diabetes may benefit from a lower dose.

  • Vitamin B12

    Supplementing with vitamin B12 may improve symptoms of diabetic neuropathy.

    Dose:

    1,500 micrograms daily
    Vitamin B12
    ×
    Vitamin B12, or cobalamin, is needed for normal functioning of nerve cells and is also involved in homocysteine metabolism. People with type 1 diabetes have an increased risk of other disorders that can affect their B12 status, such as autoimmune gastritis, celiac disease, and pernicious anemia.11 Vitamin B12, taken at a dose of 1,500 micrograms per day for 24 weeks, has been found to reduce symptoms and disability due to diabetic nerve damage (neuropathy).12 In a preliminary trial that included 544 participants with diabetic neuropathy, supplementing with vitamin B12 (in the form of methylcobalamin) along with folic acid (in the form of methylfolate) and vitamin B6 (in the form of pyridoxal-5-phosphate) for 12 weeks was associated with a 35% drop in symptom scores and a 32% drop in pain scores.13 A comparison trial in 100 subjects with diabetic neuropathy found injections of B12 were more effective than the commonly used pain medication, nortriptyline, for treating symptoms of diabetic neuropathy.14 A number of other studies have shown B12, alone and in combination with other treatments such as alpha-lipoic acid and prostaglandin E1, can be beneficial in those with diabetic neuropathy.15,16 Oral vitamin B12 up to 1,500 micrograms per day is recommended by some practitioners.

  • Vitamin B6

    People with diabetes may have an increased need for vitamin B6. Supplementing with the vitamin may help maintain normal levels and prevent type 1 diabetes complications.

    Dose:

    100 to 200 mg vitamin B6 daily
    Vitamin B6
    ×
    People with type 1 diabetes may have impaired vitamin B6 metabolism, resulting in increased susceptibility to deficiency.17 Vitamin B6, along with other B vitamins, is critical for homocysteine metabolism and may thereby reduce their risk of vascular complications of diabetes, particularly diabetes-related kidney disease. Research in people with type 1 diabetes showed supplementation with B1, B6, and B12 lowered elevated homocysteine levels and improved kidney function.18 Vitamin B6 alone, at doses of 100 to 500 mg per day, also improved kidney function in a group of people with type 1 diabetes-related kidney impairment.19 In children with type 1 diabetes, taking 100 mg of B6 per day for eight weeks led to improvements in blood vessel function.20 The benefits of B6 in people with diabetes may also be related to its apparent ability to prevent the formation of damaging advanced glycation end-products (AGEs).21

  • Vitamin D

    Vitamin D is needed to support healthy immune and pancreatic function. Supplementing with vitamin D may improve blood sugar control in those with type 1 diabetes, especially in those with low vitamin D levels.

    Dose:

    Many doctors recommend a dose of 2,000 to 4,000 IU vitamin D daily, especially in the winter months
    Vitamin D
    ×

    Vitamin D is needed to regulate immune activity and research has shown it has an important role in preventing autoimmune diseases, including type 1 diabetes.22 Vitamin D receptors have been found in the pancreas where insulin is made and some, but not all, preliminary evidence suggests that supplementation might reduce the risk of developing type 1 diabetes.23,24 Case reports even suggest a combination of high-dose vitamin D and omega-3 fatty acids may completely reverse the onset of type 1 diabetes.25,26

    Vitamin D deficiency is common in people with type 1 diabetes and associated with poor glucose control. Supplementation with cholecalciferol (vitamin D3), in doses ranging from 2,000 IU per day to about 6,000 IU per day, has been shown in randomized controlled trials to slow the decline of pancreatic function in people with newly diagnosed type 1 diabetes who have not yet suffered an extensive loss of pancreatic function.27 Furthermore, the majority of the research shows vitamin D3, in doses ranging from 2,000–10,000 IU per day, improves short and long term glycemic control in people with type 1 diabetes, particularly in those with low vitamin D status, possibly by preserving beta cell function and increasing insulin production.28,29,30,31,32,33

  • Bilberry

    Bilberry may lower the risk of some diabetic complications, such as diabetic cataracts and retinopathy.

    Dose:

    160 mg twice daily of an herbal extract containing 25% anthocyanosides
    Bilberry
    ×
    Animal research suggests bilberry extract may improve glycemic control and lower the risk of some diabetic complications, such as diabetic cataracts and retinopathy.34,35,36 Compounds called anthocyanins, found in bilberry and other dark berries, have strong antioxidant and anti-inflammatory effects that appear to mitigate some of the negative impacts of chronically elevated glucose levels.37,38 One preliminary trial found that supplementation with a standardized extract of bilberry improved signs of retinal damage in some people with diabetic retinopathy.39

  • Biotin

    Biotin may improve glucose levels and reduce pain from diabetic nerve damage.

    Dose:

    16 mg daily
    Biotin
    ×
    Biotin is a B vitamin needed to process glucose. High doses of biotin have been suggested to reverse some of the negative effects of chronic low insulin levels on glucose metabolism.40 In a pilot trial, people with type 1 diabetes given 16 mg of biotin per day for one week experienced 50% reductions in fasting glucose levels.41 In a placebo-controlled trial, people with type 1 diabetes treated with biotin at doses of about 2–4 mg per day, depending on body weight, had improvements in blood glucose regulation and blood lipid levels after three months.42 Case reports suggest biotin may also reduce pain from diabetic nerve damage (neuropathy).43 Some doctors recommend a trial of 16 mg of biotin daily for a few weeks to see if blood sugar levels decrease.

  • Chromium

    Chromium has been shown to help improve glucose tolerance in people with type 1 diabetes.

    Dose:

    200 mcg daily
    Chromium
    ×
    Chromium, a trace mineral that appears to increase the effectiveness of insulin, has been reported to improve blood glucose control in people with various forms of diabetes, including type 1 diabetes. Low chromium levels have been correlated with poor glucose control and human case studies and animal research suggest chromium supplementation may improve glycemic control and prevent some diabetic complications.44,45,46,47,48,49 The typical amount of chromium used in studies is 200 micrograms one to three times per day. Supplementation with chromium could potentially enhance the effects of drugs for diabetes (for example, insulin or other blood sugar-lowering agents) and possibly lead to hypoglycemia. Therefore, people with diabetes taking these medications should supplement with chromium only under the supervision of a doctor.

  • Coenzyme Q10

    Supplementing with CoQ10 may improve blood sugar metabolism.

    Dose:

    100 mg daily
    Coenzyme Q10
    ×
    Coenzyme Q10 (CoQ10) is needed for normal blood sugar metabolism. One research team reported that, in study subjects with vascular complications related to type 1 diabetes, adding CoQ10 to standard insulin therapy increased antioxidant status, reduced free radical damage to lipids, and improved blood vessel function.50 The same research group also reported that CoQ10 supplementation, at the unusually high dose of 1,000 mg per day, improved blood glucose control in those with type 1 diabetes-related kidney dysfunction.51 However, in a placebo-controlled trial, supplementation with 100 mg of CoQ10 per day for three months neither improved glucose control nor reduced the need for insulin in participants with type 1 diabetes.52 Although the potential benefits of CoQ10 supplements in treatment of type 1 diabetes remains uncertain, some doctors recommend taking 50–100 mg per day due to its likely ability to protect heart, blood vessel, and kidney health.53

  • Fenugreek

    Fenugreek seeds are high in soluble fiber, which helps lower blood sugar by slowing down carbohydrate digestion and absorption.

    Dose:

    3 tablespoons of fenugreek powder with each meal
    Fenugreek
    ×
    Fenugreek seeds are high in soluble fiber, which helps lower blood sugar by slowing down carbohydrate digestion and absorption.54 Fenugreek extract has also been shown to increase the number and function of insulin-producing cells in the pancreas and improve blood sugar control, lipid levels, and antioxidant capacity in animal models of type 1 diabetes.55,56,57 In a controlled study in people with type 1 diabetes, incorporating powdered fenugreek seed into lunch and dinner meals (50 grams per meal) for ten days improved several measures of blood sugar control compared to a similar ten-day diet without added fenugreek.58

  • Fiber

    Taking fiber supplements may help to stabilize your blood sugar.

    Dose:

    Refer to label instructions
    Fiber
    ×
    Dietary fiber has been found to have a small but notable positive impact on blood glucose control in people with type 1 diabetes.59 Clinical trials in people with type 1 diabetes suggest fiber supplements, when taken before meals, may reduce the post-meal rise in blood sugar.60,61 More research is needed to determine if regular use of fiber supplements benefits long-term blood sugar control in type 1 diabetes.

  • Fish Oil

    Fish oil and its omega-3 fatty acid EPA may improve blood sugar control and help prevent complications of type 1 diabetes.

    Dose:

    1,000 mg combined omega-3 fatty acids from fish, or 660 mg EPA alone, daily
    Fish Oil
    ×

    Omega-3 fatty acids from fish are well known to reduce inflammatory immune activity and have beneficial effects in a range of autoimmune conditions. Observational research suggests higher levels during infancy and early childhood may be linked to lower risk of developing type 1 diabetes.62 One study done in Norway found that babies given cod liver oil regularly during the first year of life had a 26% lower risk of developing type 1 diabetes in childhood. However, not all studies have noted a connection between omega-3 fatty acids and type 1 diabetes risk, and some researchers have proposed the discrepancies may be explained by genetic factors affecting fatty acid metabolism.63,64

    Higher intake of EPA, an omega-3 fatty acids from fish, has been correlated with better preservation of pancreatic cells that produce insulin and long-term blood glucose control in youth with type 1 diabetes.65,66 A small pilot trial found that supplementation with 630 mg of EPA and 330 mg of DHA (another omega-3 fatty acid from fish oil) per day improved blood glucose control in subjects with type 1 diabetes.67 Furthermore, better omega-3 fatty acid status may be helpful in slowing the progression of diabetes-associated complications such as kidney dysfunction and nerve pain.68,69

    Although fish oil fatty acids generally have positive effects on triglyceride levels, some studies have found supplemental DHA can increase LDL- and total cholesterol, which may increase cardiac risk. For this reason, some doctors are wary of fish oil supplements for patients with type 1 diabetes and may recommend EPA-only supplements instead.70

  • Gymnema

    Gymnema may help normalize blood sugar control in people with type 1 diabetes.

    Dose:

    400 mg daily
    Gymnema
    ×
    Test tube and animal studies have found several mechanisms by which gymnema (Gymnema sylvestre) may help normalize blood sugar control in people with diabetes, including reducing glucose absorption in the intestines, and stimulating regeneration and activity of pancreatic cells that release insulin.71,72 In a controlled trial with people with type 1 diabetes, 400 mg per day of gymnema extract improved blood glucose control and reduced requirements for insulin.73 Some practitioners recommend using gymnema extracts standardized for their content of active constituents called gymnemic acids. Gymnema is not a substitute for insulin, but insulin amounts may need to be lowered in order to avoid hypoglycemia while taking gymnema.

  • L-Carnitine

    Supplementing with acetyl l-carnitine may reduce symptoms of diabetic neuropathy in people with type 1 diabetes.

    Dose:

    1,500 to 2,000 mg daily
    L-Carnitine
    ×
    Acetyl l-carnitine is an amino acid compound used to treat conditions affecting the brain and peripheral nervous system. Research reviews have concluded acetyl l-carnitine, in doses of at least 2 grams per day, can relieve pain and improve nerve function in those with diabetic nerve damage (neuropathy).74,75 A preliminary trial found 500 mg of acetyl l-carnitine three times daily for 24 weeks relieved symptoms of diabetic nerve damage (neuropathy) as effectively as vitamin B12.76

  • Sea Buckthorn

    Animal and preliminary research suggests a connection between sea buckthorn and improved measures of blood sugar control.

    Dose:

    Refer to label instructions
    Sea Buckthorn
    ×
    Sea buckthorn (Hippophae rhamnoides) is a source of antioxidant polyphenols, and laboratory and animal studies suggest extracts from sea buckthorn have a positive impact on carbohydrate and lipid metabolism.77 In one study, a sea buckthorn extract was found to lower the rise in blood glucose that occurs after a meal in healthy men.78 In a preliminary trial, children with type 1 diabetes who consumed a concentrated mixture of sea buckthorn berries and blueberries (concentration and relative proportions not stated) for two months had improved blood measures of glucose control.79 Double-blind research using sea buckthorn alone is needed to confirm these findings and to determine an effective per day amount of sea buckthorn.

  • Selenium

    Selenium is an important antioxidant that, along with other antioxidant supplements, may help prevent complications in people with type 1 diabetes.

    Dose:

    100 to 200 micrograms daily
    Selenium
    ×
    Because oxidative damage is believed to play a role in the development of diabetic complications, such as eye damage (retinopathy), kidney damage (nephropathy), and nerve damage (neuropathy), antioxidant nutrients like selenium might play an important preventive role. In a placebo-controlled trial that included people with type 1 and type 2 diabetes and related nephropathy, those given 200 micrograms of selenium per day for 12 weeks had increased antioxidant capacity but no change in markers of kidney function.80 One doctor reported administering a per day regimen of antioxidants including 500 micrograms selenium, plus 800 IU vitamin E, 10,000 IU vitamin A, and 1,000 mg vitamin C, per day for several years to 20 people with diabetic eye damage (retinopathy). During that time, the doctor observed that 19 of the 20 people showed either improvement or no progression of their retinopathy.81 In a three-month study, taking supplements providing 100 micrograms selenium, 600 mg alpha-lipoic acid, and 1,200 IU vitamin E per day resulted in improvements in neuropathy symptoms in those with long-standing diabetes.82 People who wish to supplement with more than 250 mcg of selenium per day should consult a healthcare practitioner.

  • Taurine

    Supplementing with taurine has been found to improve blood vessel function in people with type 1 diabetes.

    Dose:

    500 mg three times daily
    Taurine
    ×
    Taurine is an amino acid that is not used in protein synthesis but serves other functions in the body. Because of its role in cardiovascular and nervous system health, it may be an important nutrient for people with type 1 diabetes.83 A small crossover trial with nine young men with type 1 diabetes found, compared to placebo, supplementing with 500 mg taurine three times per day for two weeks reduced arterial stiffness and increased the blood vessel dilation response to higher blood flow, indicating taurine improved their vascular function.84 Findings from animal studies suggest taurine supplementation may improve heart and blood vessel dysfunction associated with type 1 diabetes.85,86 Evidence from laboratory studies also suggests taurine may prevent or reverse damage to insulin-producing pancreatic cells.87 Taurine also reduced diabetes-related penile muscle scarring and erectile dysfunction in a rat model of type 1 diabetes.88,89

  • Vitamin B1

    People with type 1 diabetes may be deficient in vitamin B1. Supplementing with vitamin B1 may restore levels and improve symptoms of diabetic neuropathy.

    Dose:

    25 mg vitamin B1 with 50 mg of vitamin B6 daily or 600 mg lipid-soluble thiamine (benfotiamine) daily
    Vitamin B1
    ×

    Blood levels of vitamin B1 (thiamine) have been found to be low in people with type 1 diabetes, and low levels are correlated with greater risk of diabetes-related anemia and other complications.90,91,92 Supplementing with B1, along with vitamins B6 and B12, was found to reduce high levels of homocysteine in children type 1 diabetes in one placebo-controlled trial. High homocysteine levels are generally correlated with blood vessel dysfunction and reducing high levels may help prevent vascular complications of diabetes. In this trial, improvement in markers of kidney function were also seen.93

    Several controlled trials have evaluated the effect of benfotiamine, a fat-soluble form of vitamin B1, on diabetic neuropathy in participants with type 1 and type 2 diabetes. In one of these trials, 600 mg per day of benfotiamine was more effective than 300 mg per day or placebo for reducing neuropathic pain after six weeks; in a three-week trial, those receiving 400 mg per day of benfotiamine had greater pain reduction than those receiving placebo.94,95 However, 300 mg of benfotiamine daily had no benefits on nerve function relative to placebo in people with type 1 diabetes after 24 months, suggesting this dose may be too low to be helpful.96

  • Vitamin B3 (Niacin)

    Taking vitamin B3 (as niacin or niacinamide) might prevent or limit the severity of type 1 diabetes.

    Dose:

    Consult a qualified healthcare practitioner
    Vitamin B3 (Niacin)
    ×

    High doses of niacin (a form of vitamin B3), such as 2 to 3 grams per day, are sometimes recommended to lower high triglyceride and cholesterol levels in people with type 1 diabetes. However, niacin’s ability to reduce cardiovascular risk in the context of type 1 diabetes has not been established. It is important to note that niacin doses this high, particularly in extended release formulations, may cause flushing, stomach upset, and liver toxicity, and should be used by people with diabetes only with medical supervision.97,98

    Animal research suggests that niacinamide, a form of vitamin B3 with fewer side effects, may prevent toxic damage to the pancreatic cells that make insulin.99 Although one intriguing study found niacinamide supplementation was associated with a lower incidence of type 1 diabetes in children at high risk, more recent studies have not confirmed a protective effect.100,101

    A controlled clinical trial in subjects with recently diagnosed type 1 diabetes found the addition of niacinamide (25 mg per day per kg of body weight; approximately 2–3 grams per day) to intensive insulin treatment led to greater improvement in HgA1c over two years, but other clinical trials have found no benefit on glucose metabolism in similar subjects.102,103,104

  • Vitamin C

    Supplementing with vitamin C may benefit people with type 1 diabetes by preventing free radical damage and protecting blood vessels.

    Dose:

    1,000 mg vitamin C plus 400 IU vitamin E daily
    Vitamin C
    ×
    Vitamin C is important for lowering oxidative stress and preventing oxidative tissue damage linked to high glucose levels in people with diabetes. Vitamin C levels have been found to be lower in people with type 1 diabetes compared to healthy people, and low levels have been correlated with markers of decreased cardiovascular health in those with type 1 diabetes.105,106 In addition, because vitamin C uptake by cells is enhanced by insulin and suppressed by high glucose levels, people with type 1 diabetes have more difficulty meeting their cellular and tissue needs for vitamin C.107 In a placebo-controlled trial, 1,000 mg vitamin C along with 800 IU vitamin E per day for six months improved blood vessel function in participants with type 1 diabetes.108 Another placebo-controlled trial found the high dose of 6 grams of vitamin C per day for six months improved markers of capillary health.109 Several studies show vitamin C may protect blood vessels from free radical damage during the vulnerable periods of high blood glucose in subjects with type 1 diabetes.110,111,112,113 A small one-month study in children with type 1 diabetes found no effect of supplementation with 250 mg per day of vitamin C on vascular health. Another trial in nine type 1 diabetes-affected adolescents investigated doses of vitamin C ranging from 250–750 mg per day, depending on weight, combined with vitamin E for six weeks and saw no change in vascular function. Whether these negative findings reflect study factors such as low dose, short duration, and small number of participants is unclear.114,115

  • Açaí

    Açaí is rich in antioxidants and has been used traditionally to treat diabetes.

    Dose:

    Refer to label instructions
    Açaí
    ×
    Açaí is reported to be a traditional remedy for diabetes. Oxidative stress may contribute to diabetes onset and its complications, and açaí is rich in antioxidant polyphenols such as anthocyanins. Studies in people without diabetes show açaí consumption can raise antioxidant status in the body and improve lipid levels and blood vessel function.116,117,118 In animal research, açaí extract reduced diabetes-related kidney damage and dysfunction; however, direct evidence for açaí’s benefits in people with type 1 diabetes is lacking.119

  • Amylase Inhibitors

    Amylase inhibitors, taken with meals, may reduce the usual rise in blood sugar levels in people with diabetes.

    Dose:

    Refer to label instructions
    Amylase Inhibitors
    ×
    Substances that inhibit amylase, the digestive enzyme required to break down dietary starches into absorbable glucose units, can reduce the usual post-meal rise in blood sugar levels in both healthy people and people with diabetes. Amylase inhibitors occur naturally in foods such as whole grains and legumes, as well as in many culinary herbs and spices and medicinal herbs, possibly contributing to their anti-diabetic effects.120,121 While some food and herbal extracts with amylase-inhibiting effects have shown promise in animal research, their benefits for type 1 diabetes await confirmation in clinical trials.122

  • Asian Ginseng

    Asian ginseng is commonly used in traditional Chinese medicine to treat diabetes.

    Dose:

    Refer to label instructions
    Asian Ginseng
    ×
    Asian ginseng (Panax ginseng) is commonly used in Traditional Chinese Medicine to treat diabetes. It has been shown in test tube and animal studies to enhance the release of insulin from the pancreas and increase the number of insulin receptors.123 Asian ginseng and its active constituents have also been found to improve blood glucose control and reduce complications in animal models of type 1 diabetes.124 Clinical trials in people with type 1 diabetes are needed to confirm these findings.

  • Evening Primrose Oil

    Evening primrose oil may relieve nerve pain in those with type 1 diabetes.

    Dose:

    Refer to label instructions
    Evening Primrose Oil
    ×
    Supplementing with evening primrose oil providing 360–480 mg of gamma-linolenic acid per day for six months has been found in double-blind research to improve nerve function and relieve pain in people with diabetic nerve damage (neuropathy).125,126 However, one of the investigators involved in these clinical trials was subsequently found by the professional conduct committee of the General Medical Council (United Kingdom) to have falsified the results of his research.127 In the absence of more recent clinical trials, it is not clear whether evening primrose oil or GLA is of any value for patients with diabetic neuropathy.

  • Ginkgo

    Ginkgo may improve metabolism and help prevent complications of type 1 diabetes.

    Dose:

    Refer to label instructions
    Ginkgo
    ×
    Ginkgo (Ginkgo biloba) extract may be useful to people with type 1 diabetes because of its abilities to raise antioxidant capacity and reduce inflammatory signaling. A standardized ginkgo extract was found to improve insulin production and glucose metabolism and decrease triglyceride levels in an animal model of type 1 diabetes.128 Preliminary evidence from a trial in subjects with long-standing type 1 diabetes suggests it may have a role in protecting vision.129 Other animal research and a single small, uncontrolled, pilot trial indicate ginkgo may protect nerve function and prove useful for prevention and treatment of diabetic nerve damage (neuropathy).130,131,132

  • Glucomannan

    Glucomannan delays stomach emptying, leading to more gradual sugar absorption and possibly lowering insulin requirements for people with type 1 diabetes.

    Dose:

    Refer to label instructions
    Glucomannan
    ×
    Glucomannan is a water-soluble dietary fiber derived from konjac root (Amorphophallus konjac). Glucomannan delays stomach emptying, leading to a more gradual rise in glucose levels after eating carbohydrates. This could result in reduced need for insulin after meals in people with type 1 diabetes. In addition, glucomannan has positive effects on carbohydrate and fat metabolism, as well as the gut microbiota.133,134 These properties could lead to benefits in people with type 1 diabetes, but no research has been done to test this possibility.

  • Hibiscus

    Hibiscus is a traditional remedy in India for diabetes.

    Dose:

    Refer to label instructions
    Hibiscus
    ×
    Hibiscus is a traditional remedy in India for diabetes. Animal research suggests hibiscus extract may stimulate regeneration of pancreatic cells that produce insulin, reduce high glucose and lipid levels, and protect against damage to the heart and kidneys induced by type 1 diabetes.135,136,137 Hibiscus is usually taken as tea, 1 to 2 teaspoons (3 to 6 grams) of dried flower infused into 1 cup (250 ml) of water, three times per day.

  • Inositol

    Supplementing with inositol may improve diabetic neuropathy.

    Dose:

    Refer to label instructions
    Inositol
    ×
    Inositol, particularly in the forms myo-inositol and D-chiro-inositol, has many functions in the body, including assisting in normal cellular responsiveness to insulin.138 A gene alteration that affects inositol metabolism may be associated with risk of type 1 diabetes and its complications, and people with type 1 and type 2 diabetes have been found to lose more myo-inositol in their urine compared to those without diabetes.139,140 In one small pilot trial in seven people with type 1 diabetes, inositol supplementation (500 mg taken twice per day for two weeks) led to improved nerve function; however, two placebo-controlled trials failed to find a benefit.141,142,143

  • Manganese

    Supplementing with manganese may increase antioxidant defenses and improve blood sugar control in those with type 1 diabetes.

    Dose:

    Refer to label instructions
    Manganese
    ×
    Manganese is involved in the activity of an important antioxidant enzyme system in the body. A genetic variant linked to reduced activity of this enzymes system has been implicated as a factor in the development of type 1 diabetes and its complications.144,145,146 Low blood levels of manganese have been reported in people with type 1 and type 2 diabetes.147 Animal research suggests that manganese supplementation can improve the functioning of this enzyme system, increase insulin secretion, and improve glucose metabolism.148 One team of researchers reported on a case of a young adult with insulin-dependent diabetes who received oral manganese (3 to 5 mg per day as manganese chloride) and experienced a significant fall in blood glucose, sometimes to dangerously low levels; however, three other people with type 1 diabetes they treated with manganese supplementation had no change in blood glucose levels.149 People with type 1 diabetes wishing to supplement with manganese should do so only with a doctor’s close supervision.

  • Mistletoe

    Mistletoe extract has been found to stimulate insulin release from pancreas cells and improve health in animal models of diabetes.

    Dose:

    Refer to label instructions
    Mistletoe
    ×
    Mistletoe extract has been shown to stimulate insulin release from pancreas cells.150 Research in type 1 diabetic animals found that treatment with mistletoe extract reduced metabolic disturbances and improved general health.151,152,153 No research in humans has yet been published; however, given mistletoe’s worldwide reputation as a traditional remedy for diabetes, clinical trials are warranted to validate these promising preliminary findings. Traditionally, mistletoe is prepared by soaking 2 to 4 teaspoons (5 to 12 grams) of chopped mistletoe in 2 cups (500 ml) of water overnight. The mixture is drunk first thing in the morning and sweetened with honey if desired. Another batch may be left to steep during the day and drunk at bedtime.

  • Olive Leaf

    Olive leaf extracts have been shown to improve blood sugar control in animals with diabetes.

    Dose:

    Refer to label instructions
    Olive Leaf
    ×
    Olive leaf extract has been shown to reduce oxidative stress, inflammatory signaling, and autoimmune activity, and to improve glucose metabolism and protect pancreatic cells in animal models of type 1 diabetes.154,155,156 These results have not yet been reproduced in human clinical trials.

  • Onion

    Research in laboratory animals suggests onion and its active constituents may lower blood glucose levels, raise insulin levels, reduce advanced glycation end-product (AGE) formation, and possibly prevent diabetes complications.

    Dose:

    Refer to label instructions
    Onion
    ×
    Research in laboratory animals suggests onion and its active constituents may lower blood glucose levels, raise insulin levels, reduce advanced glycation end-product (AGE) formation, and possibly prevent diabetes complications.157,158,159 In one preliminary trial, people with type 1 diabetes had lower blood glucose levels four hours after eating about three ounces of raw onion than after receiving water.160

  • Quercetin

    Quercetin has been found to improve blood sugar control and prevent complications of diabetes in animal research.

    Dose:

    Refer to label instructions
    Quercetin
    ×
    Quercetin has demonstrated multiple actions that may benefit people with type 1 diabetes, including reducing glucose absorption, increasing insulin release, and promoting glucose uptake by cells.161 Despite a wealth of animal studies indicating its potential in prevention and treatment of diabetes and its complications, clinical trials have not yet been performed to explore whether quercetin actually benefits people with diabetes.162

  • Reishi

    Reishi may improve immune function and has demonstrated benefits in diabetic animals.

    Dose:

    Refer to label instructions
    Reishi
    ×
    Animal studies suggest reishi extract may improve immune function and wound healing in the context of type 1 diabetes.163,164 Furthermore, reishi has demonstrated anti-diabetic actions, such as lowering high glucose levels and increasing insulin levels, in animal studies.165 Clinical trials are needed to confirm these effects in humans.

  • Zinc

    Supplementing with zinc may lower blood sugar levels and improve immune function in people with type 1 diabetes.

    Dose:

    15 mg daily
    Zinc
    ×

    People with type 1 diabetes may be more likely to be zinc-deficient than their healthy counterparts. Low zinc status leads to impaired immune function and increased oxidative stress and has been linked to poorer glucose control.166,167 Zinc supplements have been found to increase antioxidant capacity and reduce lipid peroxidation in people with type 1 diabetes.168

    Despite evidence that zinc may be beneficial in people with type 1 diabetes, some doctors remain skeptical of high doses due to one 1994 study in which zinc supplementation, at a dose of 50 mg per day for 28 days, increased glycosylation (glucose-induced protein damage).169 This trial is hard to evaluate because zinc supplementation increases the life of blood cells and such an effect artificially increases the lab test results for glycosylation. In fact, laboratory studies suggest zinc can inhibit glycation.170,171 Until this issue is resolved, those with type 1 diabetes should consult a doctor before considering high-dose supplementation with zinc.

What Are Star Ratings
×
Reliable and relatively consistent scientific data showing a substantial health benefit.
Contradictory, insufficient, or preliminary studies suggesting a health benefit or minimal health benefit.
For an herb, supported by traditional use but minimal or no scientific evidence. For a supplement, little scientific support.

Holistic Options

Acupuncture may be helpful in the management of diabetes, or complications associated with the disease. In a preliminary trial, 77% of people suffering from diabetic nerve damage (neuropathy) experienced significant reduction in pain following up to six acupuncture treatments over a ten-week period. Many also were able to reduce pain medications, but no long-term change in blood-sugar control was observed.172 Bladder control problems, a complication of long-term diabetes, responded to acupuncture treatment, with a significant reduction in symptoms in both controlled and uncontrolled trials.173,174

References

1. Barrett EJ, Liu Z, Khamaisi M, et al. Diabetic Microvascular Disease: An Endocrine Society Scientific Statement. J Clin Endocrinol Metab 2017;102:4343–410.

2. Kahanovitz L, Sluss PM, Russell SJ. Type 1 Diabetes - A Clinical Perspective. Point Care 2017;16:37–40.

3. Lee HJ, Seo HI, Cha HY, et al. Diabetes and Alzheimer's Disease: Mechanisms and Nutritional Aspects. Clin Nutr Res 2018;74:229–40.

4. Piłaciński S, Zozulińska-Ziółkiewicz DA. Influence of lifestyle on the course of type 1 diabetes mellitus. Arch Med Sci 2014;10:124–34.

5. Agathos E, Tentolouris A, Eleftheriadou I, et al. Effect of alpha-lipoic acid on symptoms and quality of life in patients with painful diabetic neuropathy. J Int Med Res 2018;46:1779–90.

6. Ametov A, Barinov A, Dyck P, et al. The sensory symptoms of diabetic polyneuropathy are improved with alpha-lipoic acid: the SYDNEY trial. Diabetes Care 2003;26:770–6.

7. Han Y, Wang M, Shen J, et al. Differential efficacy of methylcobalamin and alpha-lipoic acid treatment on symptoms of diabetic peripheral neuropathy. Minerva Endocrinol 2018;43:11–8.

8. Ziegler D, Ametov A, Barinov A, et al. Oral treatment with alpha-lipoic acid improves symptomatic diabetic polyneuropathy: the SYDNEY 2 trial. Diabetes Care 2006;29:2365–70.

9. Nebbioso M, Federici M, Rusciano D, et al. Oxidative stress in preretinopathic diabetes subjects and antioxidants. Diabetes Technol Ther 2012;14:257–63.

10. Gebka A, Serkies-Minuth E, Raczynska D. Effect of the administration of alpha-lipoic acid on contrast sensitivity in patients with type 1 and type 2 diabetes. Mediators Inflamm 2014;2014:131538.

11. Angelousi A, Larger E. Anaemia, a common but often unrecognized risk in diabetic patients: a review. Diabetes Metab 2015;41:18–27.

12. Li S, Chen X, Li Q, et al. Effects of acetyl-L-carnitine and methylcobalamin for diabetic peripheral neuropathy: A multicenter, randomized, double-blind, controlled trial. J Diabetes Investig 2016;7:777–85.

13. Trippe B, Barrentine L, Curole M, Tipa E. Nutritional management of patients with diabetic peripheral neuropathy with L-methylfolate-methylcobalamin-pyridoxal-5-phosphate: results of a real-world patient experience trial. Curr Med Res Opin 2016;32:219–27.

14. Talaei A, Siavash M, Majidi H, Chehrei A. Vitamin B12 may be more effective than nortriptyline in improving painful diabetic neuropathy. Int J Food Sci Nutr 2009;60:71–6.

15. Xu Q, Pan J, Yu J, et al. Meta-analysis of methylcobalamin alone and in combination with lipoic acid in patients with diabetic peripheral neuropathy. Diabetes Res Clin Pract 2013;101:99–105.

16. Jiang D, Zhao S, Li M, et al. Prostaglandin E1 plus methylcobalamin combination therapy versus prostaglandin E1 monotherapy for patients with diabetic peripheral neuropathy: A meta-analysis of randomized controlled trials. Medicine (Baltimore) 2018;97:e13020.

17. Masse P, Boudreau J, Tranchant C, et al. Type 1 diabetes impairs vitamin B(6) metabolism at an early stage of women's adulthood. Appl Physiol Nutr Metab 2012;37:167–75.

18. Elbarbary N, Ismail E, Zaki M, et al. Vitamin B complex supplementation as a homocysteine-lowering therapy for early stage diabetic nephropathy in pediatric patients with type 1 diabetes: A randomized controlled trial. Clin Nutr 2019.

19. Williams M, Bolton W, Khalifah R, et al. Effects of pyridoxamine in combined phase 2 studies of patients with type 1 and type 2 diabetes and overt nephropathy. Am J Nephrol 2007;27:605–14.

20. MacKenzie K, Wiltshire E, Gent R, et al. Folate and vitamin B6 rapidly normalize endothelial dysfunction in children with type 1 diabetes mellitus. Pediatrics 2006;118:242–53.

21. Engelen L, Stehouwer C, Schalkwijk C. Current therapeutic interventions in the glycation pathway: evidence from clinical studies. Diabetes Obes Metab 2013;15:677–89.

22. Rak K, Bronkowska M. Immunomodulatory Effect of Vitamin D and Its Potential Role in the Prevention and Treatment of Type 1 Diabetes Mellitus-A Narrative Review. Molecules 2018;24.

23. Maddaloni E, Cavallari I, Napoli N, Conte C. Vitamin D and Diabetes Mellitus. Front Horm Res 2018;50:161–76.

24. Grammatiki M, Karras S, Kotsa K. The role of vitamin D in the pathogenesis and treatment of diabetes mellitus: a narrative review. Hormones (Athens) 2019;18:37–48.

25. Cadario F, Savastio S, Ricotti R, et al. Administration of vitamin D and high dose of omega 3 to sustain remission of type 1 diabetes. Eur Rev Med Pharmacol Sci 2018;22:512–5.

26. Cadario F, Savastio S, Rizzo A, et al. Can Type 1 diabetes progression be halted? Possible role of high dose vitamin D and omega 3 fatty acids. Eur Rev Med Pharmacol Sci 2017;21:1604–9.

27. Gregoriou E, Mamais I, Tzanetakou I, et al. The Effects of Vitamin D Supplementation in Newly Diagnosed Type 1 Diabetes Patients: Systematic Review of Randomized Controlled Trials. Rev Diabet Stud 2017;14:260–8.

28. Felicio K, de Souza A, Neto J, et al. Glycemic Variability and Insulin Needs in Patients with Type 1 Diabetes Mellitus Supplemented with Vitamin D: A Pilot Study Using Continuous Glucose Monitoring System. Curr Diabetes Rev 2018;14:395–403.

29. Bogdanou D, Penna-Martinez M, Filmann N, et al. T-lymphocyte and glycemic status after vitamin D treatment in type 1 diabetes: A randomized controlled trial with sequential crossover. Diabetes Metab Res Rev 2017;33.

30. Wierzbicka E, Szalecki M, Pludowski P, et al. Vitamin D status, body composition and glycemic control in Polish adolescents with type 1 diabetes. Minerva Endocrinol 2016;41:445–55.

31. Savastio S, Cadario F, Genoni G, et al. Vitamin D Deficiency and Glycemic Status in Children and Adolescents with Type 1 Diabetes Mellitus. PLoS One 2016;11:e0162554.

32. Hafez M, Hassan M, Musa N, et al. Vitamin D status in Egyptian children with type 1 diabetes and the role of vitamin D replacement in glycemic control. J Pediatr Endocrinol Metab 2017;30:389–94.

33. Aljabri K, Bokhari S, Khan M. Glycemic changes after vitamin D supplementation in patients with type 1 diabetes mellitus and vitamin D deficiency. Ann Saudi Med 2010;30:454–8.

34. Petlevski R, Hadzija M, Slijepcevic M, Juretic D. Effect of 'antidiabetis' herbal preparation on serum glucose and fructosamine in NOD mice. J Ethnopharmacol 2001;75:181–4.

35. Stefanescu Braic R, Vari C, Imre S, et al. Vaccinium Extracts as Modulators in Experimental Type 1 Diabetes. J Med Food 2018;21:1106–12.

36. Kim J, Kim C, Lee Y, et al. Vaccinium myrtillus extract prevents or delays the onset of diabetes-induced blood-retinal barrier breakdown. Int J Food Sci Nutr 2015;66:236–42.

37. Putta S, Yarla N, Kumar K, et al. Preventive and Therapeutic Potentials of Anthocyanins in Diabetes and Associated Complications. Curr Med Chem 2018;25:5347–71.

38. Nabavi S, Habtemariam S, Daglia M, et al. Anthocyanins as a potential therapy for diabetic retinopathy. Curr Med Chem 2015;22:51–8.

39. Scharrer A, Ober M. Anthocyanosides in the treatment of retinopathies. Klin Monatsblatt Augenheilk 1981;178:386–9.

40. McCarty M. In type 1 diabetics, high-dose biotin may compensate for low hepatic insulin exposure, promoting a more normal expression of glycolytic and gluconeogenic enyzymes and thereby aiding glycemic control. Med Hypotheses 2016;95:45–8.

41. Coggeshall J, Heggers J, Robson M, Baker H. Biotin Status and Plasma Glucose in Diabetics. Ann NY Acad Sci 1985;447:389–92.

42. Hemmati M, Babaei H, Abdolsalehei M. Survey of the effect of biotin on glycemic control and plasma lipid concentrations in type 1 diabetic patients in kermanshah in iran (2008-2009). Oman Med J 2013;28:195–8.

43. Koutsikos D, Agroyannis B, Tzanatos-Exarchou H. Biotin for diabetic peripheral neuropathy. Biomed Pharmacother 1990;44:511–4.

44. Lin C, Huang Y. Chromium, zinc and magnesium status in type 1 diabetes. Curr Opin Clin Nutr Metab Care 2015;18:588–92.

45. Peruzzu A, Solinas G, Asara Y, et al. Association of trace elements with lipid profiles and glycaemic control in patients with type 1 diabetes mellitus in northern Sardinia, Italy: An observational study. Chemosphere 2015;132:101–7.

46. Gluschenko N, Vasylyshyn K, Roschupkin A, et al. The content of microelements in blood serum and erythrocytes in children with diabetes mellitus type 1 depending on level of glycemic control. Georgian Med News 2016:66–71.

47. Littlefield D. Chromium decreases blood glucose in a patient with diabetes. J Am Diet Assoc 1994;94:1368.

48. Fox G, Sabovic Z. Chromium picolinate supplementation for diabetes mellitus. J Fam Pract 1998;46:83–6.

49. Ganguly R, Sahu S, Ohanyan V, et al. Oral chromium picolinate impedes hyperglycemia-induced atherosclerosis and inhibits proatherogenic protein TSP-1 expression in STZ-induced type 1 diabetic ApoE(-/-) mice. Sci Rep 2017;7:45279.

50. Dzugkoev S, Zangieva O, Dzugkoeva F. [Influence of combined treatment on biochemical and functional characteristics in patients with vascular complications of type 1 diabetes mellitus and different pathways of compensation]. Klin Med (Mosk) 2013;91:14–8.

51. Dzugkoev S, Kaloeva M, Dzugkoeva F. Effect of combination therapy with coenzyme Q10 on functional and metabolic parameters in patients with type 1 diabetes mellitus. Bull Exp Biol Med 2012;152:364–6.

52. Henriksen J, Andersen C, Hother-Nielsen O, et al. Impact of ubiquinone (coenzyme Q10) treatment on glycaemic control, insulin requirement and well-being in patients with Type 1 diabetes mellitus. Diabet Med 1999;16:312–8.

53. Mantle D, Hargreaves I. Coenzyme Q10 and Degenerative Disorders Affecting Longevity: An Overview. Antioxidants (Basel) 2019;8.

54. Hannan J, Ali L, Rokeya B, et al. Soluble dietary fibre fraction of Trigonella foenum-graecum (fenugreek) seed improves glucose homeostasis in animal models of type 1 and type 2 diabetes by delaying carbohydrate digestion and absorption and enhancing insulin action. Br J Nutr 2007;97:514–21.

55. Liu L, Du X, Zhang Z, Zhou J. Trigonelline inhibits caspase 3 to protect beta cells apoptosis in streptozotocin-induced type 1 diabetic mice. Eur J Pharmacol 2018;836:115–21.

56. Haeri M, Limaki H, White C, White K. Non-insulin dependent anti-diabetic activity of (2S, 3R, 4S) 4-hydroxyisoleucine of fenugreek (Trigonella foenum graecum) in streptozotocin-induced type I diabetic rats. Phytomedicine 2012;19:571–4.

57. Raju J, Gupta D, Rao A, et al. Trigonellafoenum graecum (fenugreek) seed powder improves glucose homeostasis in alloxan diabetic rat tissues by reversing the altered glycolytic, gluconeogenic and lipogenic enzymes. Mol Cell Biochem 2001;224:45–51.

58. Sharma R, Raghuram T, Rao N. Effect of fenugreek seeds on blood glucose and serum lipids in type I diabetes. Eur J Clin Nutr 1990;44:301–6.

59. Basu A, Alman A, Snell-Bergeon J. Dietary fiber intake and glycemic control: coronary artery calcification in type 1 diabetes (CACTI) study. Nutr J 2019;18:23.

60. Nader N, Weaver A, Eckert S, Lteif A. Effects of fiber supplementation on glycemic excursions and incidence of hypoglycemia in children with type 1 diabetes. Int J Pediatr Endocrinol 2014;2014:13.

61. Vuorinen-Markkola H, Sinisalo M, Koivisto VA. Guar gum in insulin-dependent diabetes: effects on glycemic control and serum lipoproteins. Am J Clin Nutr 1992;56:1056–60.

62. Niinisto S, Takkinen H, Erlund I, et al. Fatty acid status in infancy is associated with the risk of type 1 diabetes-associated autoimmunity. Diabetologia 2017;60:1223–33.

63. Norris J, Kroehl M, Fingerlin T, et al. Erythrocyte membrane docosapentaenoic acid levels are associated with islet autoimmunity: The Diabetes Autoimmunity Study in the Young. Diabetologia 2014;57:295–304.

64. Miller M, Yin X, Seifert J, et al. Erythrocyte membrane omega-3 fatty acid levels and omega-3 fatty acid intake are not associated with conversion to type 1 diabetes in children with islet autoimmunity: the Diabetes Autoimmunity Study in the Young (DAISY). Pediatr Diabetes 2011;12:669–75.

65. Lamichhane A, Crandell J, Jaacks L, et al. Longitudinal associations of nutritional factors with glycated hemoglobin in youth with type 1 diabetes: the SEARCH Nutrition Ancillary Study. Am J Clin Nutr 2015;101:1278–85.

66. Mayer-Davis E, Dabelea D, Crandell J, et al. Nutritional factors and preservation of C-peptide in youth with recently diagnosed type 1 diabetes: SEARCH Nutrition Ancillary Study. Diabetes Care 2013;36:1842–50.

67. Stiefel P, Ruiz-Gutierrez V, Gajon E, et al. Sodium transport kinetics, cell membrane lipid composition, neural conduction and metabolic control in type 1 diabetic patients. Changes after a low-dose n-3 fatty acid dietary intervention. Ann Nutr Metab 1999;43:113–20.

68. Lee C, Sharp S, Wexler D, Adler A. Dietary intake of eicosapentaenoic and docosahexaenoic acid and diabetic nephropathy: cohort analysis of the diabetes control and complications trial. Diabetes Care 2010;33:1454–6.

69. Lewis E, Perkins B, Lovblom L, et al. Effect of omega-3 supplementation on neuropathy in type 1 diabetes: A 12-month pilot trial. Neurology 2017;88:2294–301.

70. Gutstein A, Copple T. Cardiovascular disease and omega-3s: Prescription products and fish oil dietary supplements are not the same. J Am Assoc Nurse Pract 2017;29:791–801.

71. Tiwari P, Ahmad K, Baig M. Gymnema sylvestre for Diabetes: From Traditional Herb to Future's Therapeutic. Curr Pharm Des 2017;23:1667–76.

72. Shenoy R, Prashanth K, Manonmani H. In Vitro Antidiabetic Effects of Isolated Triterpene Glycoside Fraction from Gymnema sylvestre.Evid Based Complement Alternat Med 2018;2018:7154702.

73. Shanmugasundaram E, Rajeswari G, Baskaran K, et al. Use of Gymnema sylvestre leaf extract in the control of blood glucose in insulin-dependent diabetes mellitus. J Ethnopharmacol 1990;30:281–94.

74. Sima A. Acetyl-L-carnitine in diabetic polyneuropathy: experimental and clinical data. CNS Drugs 2007;21:13–23.

75. Evans J, Jacobs T, Evans E. Role of acetyl-L-carnitine in the treatment of diabetic peripheral neuropathy. Ann Pharmacother 2008;42:1686–91.

76. Li S, Chen X, Li Q, et al. Effects of acetyl-L-carnitine and methylcobalamin for diabetic peripheral neuropathy: A multicenter, randomized, double-blind, controlled trial. J Diabetes Investig 2016;7:777–85.

77. Dragan S, Andrica F, Serban M, Timar R. Polyphenols-rich natural products for treatment of diabetes. Curr Med Chem 2015;22:14–22.

78. Lehtonen H, Jarvinen R, Linderborg K, et al. Postprandial hyperglycemia and insulin response are affected by sea buckthorn (Hippophae rhamnoides ssp. turkestanica) berry and its ethanol-soluble metabolites. Eur J Clin Nutr 2010;64:1465–71.

79. Dunca I, et al. Effect of a dietary supplement containing blueberry and sea buckthorn concentrate on antioxidant capacity in type 1 diabetic children. Acta Physiol Hung 2008;95:383–93.

80. Bahmani F, Kia M, Soleimani A, et al. Effect of Selenium Supplementation on Glycemic Control and Lipid Profiles in Patients with Diabetic Nephropathy. Biol Trace Elem Res 2016;172:282–9.

81. Crary E, McCarty M. Potential clinical applications for high-dose nutritional antioxidants. Med Hypotheses 1984;13:77–98.

82. Kahler W, Kuklinski B, Ruhlmann C, Plotz C. [Diabetes mellitus--a free radical-associated disease. Results of adjuvant antioxidant supplementation]. Z Gesamte Inn Med 1993;48:223–32.

83. Sirdah M. Protective and therapeutic effectiveness of taurine in diabetes mellitus: a rationale for antioxidant supplementation. Diabetes Metab Syndr 2015;9:55–64.

84. Moloney M, Casey R, O'Donnell D, et al. Two weeks taurine supplementation reverses endothelial dysfunction in young male type 1 diabetics. Diab Vasc Dis Res 2010;7:300–10.

85. Wang G, Li W, Lu X, et al. Taurine attenuates oxidative stress and alleviates cardiac failure in type I diabetic rats. Croat Med J 2013;54:171–9.

86. Wang L, Yu Y, Zhang L, et al. Taurine rescues vascular endothelial dysfunction in streptozocin-induced diabetic rats: correlated with downregulation of LOX-1 and ICAM-1 expression on aortas. Eur J Pharmacol 2008;597:75–80.

87. Gavrovskaya L, Ryzhova O, Safonova A, et al. Protective effect of taurine on rats with experimental insulin-dependent diabetes mellitus. Bull Exp Biol Med 2008;146:226–8.

88. Ruan Y, Li M, Wang T, et al. Taurine Supplementation Improves Erectile Function in Rats with Streptozotocin-induced Type 1 Diabetes via Amelioration of Penile Fibrosis and Endothelial Dysfunction. J Sex Med 2016;13:778–85.

89. Arany E, Strutt B, Romanus P, et al. Taurine supplement in early life altered islet morphology, decreased insulitis and delayed the onset of diabetes in non-obese diabetic mice. Diabetologia 2004;47:1831–7.

90. Al-Daghri N, Alharbi M, Wani K, et al. Biochemical changes correlated with blood thiamine and its phosphate esters levels in patients with diabetes type 1 (DMT1). Int J Clin Exp Pathol 2015;8:13483–8.

91. Thornalley P, Babaei-Jadidi R, Al Ali H, et al. High prevalence of low plasma thiamine concentration in diabetes linked to a marker of vascular disease. Diabetologia 2007;50:2164–70.

92. Angelousi A, Larger E. Anaemia, a common but often unrecognized risk in diabetic patients: a review. Diabetes Metab 2015;41:18–27.

93. Elbarbary N, Ismail E, Zaki M, et al. Vitamin B complex supplementation as a homocysteine-lowering therapy for early stage diabetic nephropathy in pediatric patients with type 1 diabetes: A randomized controlled trial. Clin Nutr 2019.

94. Stracke H, Gaus W, Achenbach U, et al. Benfotiamine in diabetic polyneuropathy (BENDIP): results of a randomised, double blind, placebo-controlled clinical study. Exp Clin Endocrinol Diabetes 2008;116:600–5.

95. Haupt E, Ledermann H, Kopcke W. Benfotiamine in the treatment of diabetic polyneuropathy—a three-week randomized, controlled pilot study (BEDIP study). Int J Clin Pharmacol Ther 2005;43:71–7.

96. Fraser D, Diep L, Hovden I, et al. The effects of long-term oral benfotiamine supplementation on peripheral nerve function and inflammatory markers in patients with type 1 diabetes: a 24-month, double-blind, randomized, placebo-controlled trial. Diabetes Care 2012;35:1095–7.

97. Nagalski A, Bryla J. [Niacin in therapy]. Postepy Hig Med Dosw (Online) 2007;61:288-302.

98. Subramanian S, Chait A. Hypertriglyceridemia secondary to obesity and diabetes. Biochim Biophys Acta 2012;1821:819–25.

99. Fukaya M, Tamura Y, Chiba Y, et al. Protective effects of a nicotinamide derivative, isonicotinamide, against streptozotocin-induced beta-cell damage and diabetes in mice. Biochem Biophys Res Commun 2013;442:92–8.

100. Elliott R, Pilcher C, Stewart A, et al. The use of nicotinamide in the prevention of type 1 diabetes. Ann N Y Acad Sci 1993;696:333–41.

101. Skyler J. Primary and secondary prevention of Type 1 diabetes. Diabet Med 2013;30:161–9.

102. Crino A, Schiaffini R, Ciampalini P, et al. A two-year observational study of nicotinamide and intensive insulin therapy in patients with recent onset type 1 diabetes mellitus. J Pediatr Endocrinol Metab 2005;18:749–54.

103. Visalli N, Cavallo MG, Signore A, et al. A multi-centre randomized trial of two different doses of nicotinamide in patients with recent-onset type 1 diabetes (The IMDIAB VI). Diabetes Metab Res Rev 1999;15:181–5.

104. Crino A, Schiaffini R, Manfrini S, et al. A randomized trial of nicotinamide and vitamin E in children with recent onset type 1 diabetes (IMDIAB IX). Eur J Endocrinol 2004;150:719–24.

105. Fatima N, Faisal S, Zubair S, et al. Role of Pro-Inflammatory Cytokines and Biochemical Markers in the Pathogenesis of Type 1 Diabetes: Correlation with Age and Glycemic Condition in Diabetic Human Subjects. PLoS One 2016;11:e0161548.

106. Odermarsky M, Lykkesfeldt J, Liuba P. Poor vitamin C status is associated with increased carotid intima-media thickness, decreased microvascular function, and delayed myocardial repolarization in young patients with type 1 diabetes. Am J Clin Nutr 2009;90:447–52.

107. Cunningham J. The glucose/insulin system and vitamin C: implications in insulin-dependent diabetes mellitus. J Am Coll Nutr 1998;17:105–8.

108. Beckman J, Goldfine A, Gordon M, et al. Oral antioxidant therapy improves endothelial function in Type 1 but not Type 2 diabetes mellitus. Am J Physiol Heart Circ Physiol 2003;285:H2392–8.

109. Juhl B, Klein F, Christiansen J. Vitamin C treatment reduces transcapillary escape rate of albumin in type 1 diabetes. Eur J Intern Med 2004;15:428–35.

110. Ceriello A, Novials A, Ortega E, et al. Evidence that hyperglycemia after recovery from hypoglycemia worsens endothelial function and increases oxidative stress and inflammation in healthy control subjects and subjects with type 1 diabetes. Diabetes 2012;61:2993–7.

111. Ceriello A, Novials A, Ortega E, et al. Vitamin C further improves the protective effect of GLP-1 on the ischemia-reperfusion-like effect induced by hyperglycemia post-hypoglycemia in type 1 diabetes. Cardiovasc Diabetol 2013;12:97.

112. Hoffman R, Dye A, Bauer J. Ascorbic acid blocks hyperglycemic impairment of endothelial function in adolescents with type 1 diabetes. Pediatr Diabetes 2012;13:607–10.

113. Ceriello A, Novials A, Ortega E, et al. Vitamin C further improves the protective effect of glucagon-like peptide-1 on acute hypoglycemia-induced oxidative stress, inflammation, and endothelial dysfunction in type 1 diabetes. Diabetes Care 2013;36:4104–8.

114. Sabri M, Tavana E, Ahmadi A, et al. The effect of vitamin C on endothelial function of children with type 1 diabetes: an experimental study. Int J Prev Med 2014;5:999–1004.

115. Cazeau R, Huang H, Bauer J, et al. Effect of Vitamins C and E on Endothelial Function in Type 1 Diabetes Mellitus. J Diabetes Res 2016;2016:3271293.

116. Pala D, Barbosa P, Silva C, et al. Acai (Euterpe oleracea Mart.) dietary intake affects plasma lipids, apolipoproteins, cholesteryl ester transfer to high-density lipoprotein and redox metabolism: A prospective study in women. Clin Nutr 2018;37:618–23.

117. Udani J, Singh B, Singh V, et al. Effects of Acai (Euterpe oleracea Mart.) berry preparation on metabolic parameters in a healthy overweight population: a pilot study. Nutr J 2011;10:45.

118. Alqurashi R, Galante L, Rowland I, et al. Consumption of a flavonoid-rich acai meal is associated with acute improvements in vascular function and a reduction in total oxidative status in healthy overweight men. Am J Clin Nutr 2016;104:1227–35.

119. da Silva Cristino Cordeiro V, de Bem G, da Costa C, et al. Euterpe oleracea Mart. seed extract protects against renal injury in diabetic and spontaneously hypertensive rats: role of inflammation and oxidative stress. Eur J Nutr 2018;57:817–32.

120. Alam F, Shafique Z, Amjad S, et al. Enzymes inhibitors from natural sources with antidiabetic activity: A review. Phytother Res 2019;33:41–54.

121. Takahama U, Hirota S. Interactions of flavonoids with alpha-amylase and starch slowing down its digestion. Food Funct 2018;9:677–87.

122. Najafian M, Ebrahim-Habibi A, Yaghmaei P, et al. Core structure of flavonoids precursor as an antihyperglycemic and antihyperlipidemic agent: an in vivo study in rats. Acta Biochim Pol 2010;57:553–60.

123. Szczuka D, Nowak A, Zaklos-Szyda M, et al. American Ginseng (Panax quinquefolium L.) as a Source of Bioactive Phytochemicals with Pro-Health Properties. Nutrients 2019;11.

124. Bai L, Gao J, Wei F, et al. Therapeutic Potential of Ginsenosides as an Adjuvant Treatment for Diabetes. Front Pharmacol 2018;9:423.

125. Keen H, Payan J, Allawi J, et al. Treatment of diabetic neuropathy with gamma-linolenic acid. Diabetes Care 1993;16:8–15.

126. Jamal G, Carmichael H. The effect of gamma-linolenic acid on human diabetic peripheral neuropathy: a double-blind placebo-controlled trial. Diabet Med 1990;7:319–23.

127. Dyer O. GMC reprimands doctor for research fraud. BMJ 2003;326:730.

128. Rhee K, Lee C, Kim S, et al. Extract of Ginkgo Biloba Ameliorates Streptozotocin-Induced Type 1 Diabetes Mellitus and High-Fat Diet-Induced Type 2 Diabetes Mellitus in Mice. Int J Med Sci 2015;12:987–94.

129. Bernardczyk-Meller J, Siwiec-Proscinska J, Stankiewicz W, et al. [Influence of Eqb 761 on the function of the retina in children and adolescent with long lasting diabetes mellitus—preliminary report]. Klin Oczna 2004;106:569–71.

130. Kim J, Yokoyama K, Araki S. The effects of Ginkgo biloba extract (GBe) on axonal transport microvasculature and morphology of sciatic nerve in streptozotocin-induced diabetic rats. Environ Health Prev Med 2000;5:53–9.

131. da Silva G, Zanoni J, Buttow N. Neuroprotective action of Ginkgo biloba on the enteric nervous system of diabetic rats. World J Gastroenterol 2011;17:898–905.

132. Koltringer P, Langsteger W, Lind P, et al. [Ginkgo biloba extract and folic acid in the therapy of changes caused by autonomic neuropathy]. Acta Med Austriaca 1989;16:35–7 [in German].

133. Behera S, Ray R. Konjac glucomannan, a promising polysaccharide of Amorphophallus konjac K. Koch in health care. Int J Biol Macromol 2016;92:942–56.

134. Devaraj R, Reddy C, Xu B. Health-promoting effects of konjac glucomannan and its practical applications: A critical review. Int J Biol Macromol 2019;126:273–81.

135. Adeyemi D, Adewole O. Hibiscus sabdariffa renews pancreatic beta-cells in experimental type 1 diabetic model rats. Morphologie 2019;103:80–93.

136. Mohammed Yusof N, Zainalabidin S, Mohd Fauzi N, Budin S. Hibiscus sabdariffa (roselle) polyphenol-rich extract averts cardiac functional and structural abnormalities in type 1 diabetic rats. Appl Physiol Nutr Metab 2018;43:1224–32.

137. Lee W, Wang C, Chen Y, et al. Polyphenol extracts from Hibiscus sabdariffa Linnaeus attenuate nephropathy in experimental type 1 diabetes. J Agric Food Chem 2009;57:2206–10.

138. Croze M, Soulage C. Potential role and therapeutic interests of myo-inositol in metabolic diseases. Biochimie 2013;95:1811–27.

139. Yang B, Hodgkinson A, Millward B, Demaine A. Polymorphisms of myo-inositol oxygenase gene are associated with Type 1 diabetes mellitus. J Diabetes Complications 2010;24:404–8.

140. Jung T, Hahm J, Kim J, et al. Determination of urinary Myo-/chiro-inositol ratios from Korean diabetes patients. Yonsei Med J 2005;46:532–8.

141. Salway J, Whitehead L, Finnegan J, et al. Effect of myo-inositol on peripheral-nerve function in diabetes. Lancet 1978;2:1282–4.

142. Gregersen G, Bertelsen B, Harbo H, et al. Oral supplementation of myoinositol: effects on peripheral nerve function in human diabetics and on the concentration in plasma, erythrocytes, urine and muscle tissue in human diabetics and normals. Acta Neurol Scand 1983;67:164–72.

143. Gregersen G, Borsting H, Theil P, Servo C. Myoinositol and function of peripheral nerves in human diabetics. Acta Neurol Scand 1978;58:241–8.

144. Mohammedi K, Bellili-Munoz N, Driss F, et al. Manganese superoxide dismutase (SOD2) polymorphisms, plasma advanced oxidation protein products (AOPP) concentration and risk of kidney complications in subjects with type 1 diabetes. PLoS One 2014;9:e96916.

145. Mollsten A, Jorsal A, Lajer M, et al. The V16A polymorphism in SOD2 is associated with increased risk of diabetic nephropathy and cardiovascular disease in type 1 diabetes. Diabetologia 2009;52:2590–3.

146. Kangas-Kontio T, Vavuli S, Kakko S, et al. Polymorphism of the manganese superoxide dismutase gene but not of vascular endothelial growth factor gene is a risk factor for diabetic retinopathy. Br J Ophthalmol 2009;93:1401–6.

147. Forte G, Bocca B, Peruzzu A, et al. Blood metals concentration in type 1 and type 2 diabetics. Biol Trace Elem Res 2013;156:79–90.

148. Lee S, Jouihan H, Cooksey R, et al. Manganese supplementation protects against diet-induced diabetes in wild type mice by enhancing insulin secretion. Endocrinology 2013;154:1029–38.

149. Manganese-Induced Hypoglycemia. JAMA 1963;183:227.

150. Park J, Kim Y, Kim J, et al. Viscothionin purified from mistletoe (Viscum album var. coloratum Ohwi) induces insulin secretion from pancreatic beta cells. J Ethnopharmacol 2019;234:172–9.

151. Abdallah H, Farag M, Abdel-Naim A, et al. Mechanistic Evidence of Viscum schimperi (Viscaceae) Antihyperglycemic Activity: From a Bioactivity-guided Approach to Comprehensive Metabolite Profiling. Phytother Res 2015;29:1737–43.

152. Eno A, Ofem O, Nku C, et al. Stimulation of insulin secretion by Viscum album (mistletoe) leaf extract in streptozotocin-induced diabetic rats. Afr J Med Med Sci 2008;37:141–7.

153. Turkkan A, Savas H, Yavuz B, et al. The prophylactic effect of Viscum album in streptozotocin-induced diabetic rats. North Clin Istanb 2016;3:83–9.

154. Almalki D, Alghamdi S, Al-Attar A. Comparative Study on the Influence of Some Medicinal Plants on Diabetes Induced by Streptozotocin in Male Rats. Biomed Res Int 2019;2019:3596287.

155. Park J, Jung J, Yang J, Kim H. Olive leaf down-regulates the oxidative stress and immune dysregulation in streptozotocin-induced diabetic mice. Nutr Res 2013;33:942–51.

156. Cvjeticanin T, Miljkovic D, Stojanovic I, et al. Dried leaf extract of Olea europaea ameliorates islet-directed autoimmunity in mice. Br J Nutr 2010;103:1413–24.

157. Pradeep S, Srinivasan K. Amelioration of hyperglycemia and associated metabolic abnormalities by a combination of fenugreek (Trigonella foenum-graecum) seeds and onion (Allium cepa) in experimental diabetes. J Basic Clin Physiol Pharmacol 2017;28:493–505.

158. Abouzed T, Contreras M, Sadek K, et al. Red onion scales ameliorated streptozotocin-induced diabetes and diabetic nephropathy in Wistar rats in relation to their metabolite fingerprint. Diabetes Res Clin Pract 2018;140:253–64.

159. Ikechukwu O, Ifeanyi O. The Antidiabetic Effects of The Bioactive Flavonoid (Kaempferol-3-O-beta-D-6{P- Coumaroyl} Glucopyranoside) Isolated from Allium cepa.Recent Pat Antiinfect Drug Discov 2016;11:44–52.

160. Taj Eldin I, Ahmed E, Elwahab H. Preliminary Study of the Clinical Hypoglycemic Effects of Allium cepa (Red Onion) in Type 1 and Type 2 Diabetic Patients. Environ Health Insights 2010;4:71–7.

161. Eid H, Haddad P. The Antidiabetic Potential of Quercetin: Underlying Mechanisms. Curr Med Chem 2017;24:355–64.

162. Shi G, Li Y, Cao Q, et al. In vitro and in vivo evidence that quercetin protects against diabetes and its complications: A systematic review of the literature. Biomed Pharmacother 2019;109:1085–99.

163. Yurkiv B, Wasser S, Nevo E, Sybirna N. The Effect of Agaricus brasiliensis and Ganoderma lucidum Medicinal Mushroom Administration on the L-arginine/Nitric Oxide System and Rat Leukocyte Apoptosis in Experimental Type 1 Diabetes Mellitus. Int J Med Mushrooms 2015;17:339–50.

164. Tie L, Yang H, An Y, et al. Ganoderma lucidum polysaccharide accelerates refractory wound healing by inhibition of mitochondrial oxidative stress in type 1 diabetes. Cell Physiol Biochem 2012;29:583–94.

165. Ma H, Hsieh J, Chen S. Anti-diabetic effects of Ganoderma lucidum. Phytochemistry 2015;114:109–13.

166. Jansen J, Rosenkranz E, Overbeck S, et al. Disturbed zinc homeostasis in diabetic patients by in vitro and in vivo analysis of insulinomimetic activity of zinc. J Nutr Biochem 2012;23:1458–66.

167. Lin C, Huang Y. Chromium, zinc and magnesium status in type 1 diabetes. Curr Opin Clin Nutr Metab Care 2015;18:588–92.

168. Jayawardena R, Ranasinghe P, Galappatthy P, et al. Effects of zinc supplementation on diabetes mellitus: a systematic review and meta-analysis. Diabetol Metab Syndr 2012;4:13.

169. Cunningham J, Fu A, Mearkle P, Brown R. Hyperzincuria in individuals with insulin-dependent diabetes mellitus: concurrent zinc status and the effect of high-dose zinc supplementation. Metabolism 1994;43:1558–62.

170. Seneviratne C, Dombi G, Liu W, Dain J. The in vitro glycation of human serum albumin in the presence of Zn(II). J Inorg Biochem 2011;105:1548–54.

171. Tarwadi K, Agte V. Effect of micronutrients on methylglyoxal-mediated in vitro glycation of albumin. Biol Trace Elem Res 2011;143:717–25.

172. Abuaisha BB, Costanzi JB, Boulton AJ. Acupuncture for the treatment of chronic painful peripheral diabetic neuropathy: a long-term study. Diabetes Res Clin Pract 1998;39:115-21.

173. Zheg HT, Huang XM, Sun JH. Treatment of diabetic cystopathy by acupuncture and moxibustion. J Tradit Chin Med 1986;6:243-8.

174. Zhang W. Acupuncture for treatment of diabetic urinary bladder neural dysfunction—a report of 36 cases. J Tradit Chin Med 1997;17:211-3.

175. Nansel T, Lipsky L, Liu A. Greater diet quality is associated with more optimal glycemic control in a longitudinal study of youth with type 1 diabetes. Am J Clin Nutr 2016;104:81–7.

176. Giacco R, Parillo M, Rivellese AA, et al. Long-term dietary treatment with increased amounts of fiber-rich low-glycemic index natural foods improves blood glucose control and reduces the number of hypoglycemic events in type 1 diabetic patients. Diabetes Care 2000;23:1461–6.

177. Queiroz K, Novato Silva I, de Cassia Goncalves Alfenas R. Influence of the glycemic index and glycemic load of the diet in the glycemic control of diabetic children and teenagers. Nutr Hosp 2012;27:510–5.

178. Thomas D, Elliott E. Low glycaemic index, or low glycaemic load, diets for diabetes mellitus. Cochrane Database Syst Rev 2009:Cd006296.

179. Bozzetto L, Giorgini M, Alderisio A, et al. Glycaemic load versus carbohydrate counting for insulin bolus calculation in patients with type 1 diabetes on insulin pump. Acta Diabetol 2015;52:865–71.

180. Paterson M, King B, Smart C, et al. Impact of dietary protein on postprandial glycaemic control and insulin requirements in Type 1 diabetes: a systematic review. Diabet Med 2019.

181. Ko G, Obi Y, Tortorici A, Kalantar-Zadeh K. Dietary protein intake and chronic kidney disease. Curr Opin Clin Nutr Metab Care 2017;20:77–85.

182. Evert A, Dennison M, Gardner C, et al. Nutrition Therapy for Adults with Diabetes or Prediabetes: A Consensus Report. Diabetes Care 2019;42:731–54.

183. Muntoni S, Cocco P, Aru G, Cucca F. Nutritional factors and worldwide incidence of childhood type 1 diabetes. Am J Clin Nutr 2000;71:1525–9.

184. Lamb M, Miller M, Seifert J, et al. The effect of childhood cow's milk intake and HLA-DR genotype on risk of islet autoimmunity and type 1 diabetes: the Diabetes Autoimmunity Study in the Young. Pediatr Diabetes 2015;16:31–8.

185. Luopajarvi K, Savilahti E, Virtanen S, et al. Enhanced levels of cow's milk antibodies in infancy in children who develop type 1 diabetes later in childhood. Pediatr Diabetes 2008;9:434–41.

186. Knip M, Virtanen SM, Seppä K, et al. Dietary intervention in infancy and later signs of beta-cell autoimmunity. N Engl J Med 2010;363:1900–8.

187. Knip M, Akerblom H, Al Taji E, et al. Effect of Hydrolyzed Infant Formula vs Conventional Formula on Risk of Type 1 Diabetes: The TRIGR Randomized Clinical Trial. JAMA 2018;319:38–48.

188. Vaarala O, Ilonen J, Ruohtula T, et al. Removal of Bovine Insulin from Cow's Milk Formula and Early Initiation of Beta-Cell Autoimmunity in the FINDIA Pilot Study. Arch Pediatr Adolesc Med 2012;166:608–14.

189. Strychar I, Cohn J, Renier G, et al. Effects of a diet higher in carbohydrate/lower in fat versus lower in carbohydrate/higher in monounsaturated fat on postmeal triglyceride concentrations and other cardiovascular risk factors in type 1 diabetes. Diabetes Care 2009;32:1597–9.

190. Strychar I, Ishac A, Rivard M, et al. Impact of a high-monounsaturated-fat diet on lipid profile in subjects with type 1 diabetes. J Am Diet Assoc 2003;103:467–74.

191. Donaghue K, Pena M, Chan A, et al. Beneficial effects of increasing monounsaturated fat intake in adolescents with type 1 diabetes. Diabetes Res Clin Pract 2000;48:193–9.

192. Bozzetto L, Alderisio A, Clemente G, et al. Gastrointestinal effects of extra-virgin olive oil associated with lower postprandial glycemia in type 1 diabetes. Clin Nutr 2018.

193. Bozzetto L, Alderisio A, Giorgini M, et al. Extra-Virgin Olive Oil Reduces Glycemic Response to a High-Glycemic Index Meal in Patients with Type 1 Diabetes: A Randomized Controlled Trial. Diabetes Care 2016;39:518–24.

194. Evert A, Dennison M, Gardner C, et al. Nutrition Therapy for Adults with Diabetes or Prediabetes: A Consensus Report. Diabetes Care 2019;42:731–54.

195. Added Sugars. American Heart Association [updated 2018 Apr 17]. Available from URL: https://www.heart.org/en/healthy-living/healthy-eating/eat-smart/sugar/added-sugars.

196. Wu N, Bredin S, Guan Y, et al. Cardiovascular Health Benefits of Exercise Training in Persons Living with Type 1 Diabetes: A Systematic Review and Meta-Analysis. J Clin Med 2019;8.

197. Houlder S, Yardley J. Continuous Glucose Monitoring and Exercise in Type 1 Diabetes: Past, Present and Future. Biosensors (Basel) 2018;8.

198. Evert A, Dennison M, Gardner C, et al. Nutrition Therapy for Adults with Diabetes or Prediabetes: A Consensus Report. Diabetes Care 2019;42:731–54.

199. Tetzschner R, Norgaard K, Ranjan A. Effects of alcohol on plasma glucose and prevention of alcohol-induced hypoglycemia in type 1 diabetes-A systematic review with GRADE. Diabetes Metab Res Rev 2018;34.

200. Harjutsalo V, Feodoroff M, Forsblom C, Groop P. Patients with Type 1 diabetes consuming alcoholic spirits have an increased risk of microvascular complications. Diabet Med 2014;31:156–64.

201. Beulens J, Kruidhof J, Grobbee D, et al. Alcohol consumption and risk of microvascular complications in type 1 diabetes patients: the EURODIAB Prospective Complications Study. Diabetologia 2008;51:1631–8.

202. Zhu P, Pan X, Sheng L, et al. Cigarette Smoking, Diabetes, and Diabetes Complications: Call for Urgent Action. Curr Diab Rep 2017;17:78.

203. Heinemann L, Stuhr A, Brown A, et al. Self-measurement of Blood Glucose and Continuous Glucose Monitoring—Is There Only One Future? Eur Endocrinol 2018;14:24–9.

204. Bloomgarden Z. Beyond HbA1c. J Diabetes 2017;9:1052–3.

205. Galderisi A, Sherr J. A Technological Revolution: The Integration of New Treatments to Manage Type 1 Diabetes. Pediatr Ann 2019;48:e311–8.

206. Ruedy K, Parkin C, Riddlesworth T, Graham C. Continuous Glucose Monitoring in Older Adults with Type 1 and Type 2 Diabetes Using Multiple Per day Injections of Insulin: Results from the DIAMOND Trial. J Diabetes Sci Technol 2017;11:1138–46.

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The information presented by TraceGains is for informational purposes only. It is based on scientific studies (human, animal, or in vitro), clinical experience, or traditional usage as cited in each article. The results reported may not necessarily occur in all individuals. Self-treatment is not recommended for life-threatening conditions that require medical treatment under a doctor's care. For many of the conditions discussed, treatment with prescription or over the counter medication is also available. Consult your doctor, practitioner, and/or pharmacist for any health problem and before using any supplements or before making any changes in prescribed medications. Information expires December 2024.

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