Msg Sensitivity

Health Condition

MSG Sensitivity

  • Vitamin B6

    In one study, eight out of nine people stopped reacting to MSG when given vitamin B6. Many doctors suggest that people having MSG-sensitivity symptoms try supplementing with vitamin B6 for three months as a trial.

    Dose:

    Refer to label instructions
    Vitamin B6
    ×
     

    Years ago, researchers discovered that animals who were deficient in vitamin B6 could not properly process MSG.14 Typical reactions to MSG have also been linked to vitamin B6 deficiency in people.15 In one study, eight out of nine such people stopped reacting to MSG when given 50 mg of vitamin B6 per day for at least 12 weeks.

    The actual percentage of people with MSG sensitivity who are deficient in vitamin B6 and who respond to B6 supplementation is unknown. Nonetheless, many doctors suggest that people having MSG-sensitivity symptoms try supplementing with vitamin B6 for three months as a trial.

What Are Star Ratings
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Reliable and relatively consistent scientific data showing a substantial health benefit.
Contradictory, insufficient, or preliminary studies suggesting a health benefit or minimal health benefit.
For an herb, supported by traditional use but minimal or no scientific evidence. For a supplement, little scientific support.

References

1. Kwok RHM. Chinese-restaurant syndrome. N Engl J Med 1968;278:796 [letter].

2. Prawirohardjono W, Dwiprahasto I, Astuti I, et al. The administration to Indonesians of monosodium L-glutamate in Indonesian foods: an assessment of adverse reactions in a randomized double-blind, crossover, placebo-controlled study. J Nutr 2000;130(4S Suppl):1074-6S.

3. Bazzano G, D'Elia JA, Olson RE. Monosodium glutamate: feeding of large amounts in man and gerbils. Science 1970;169:1208-9.

4. Morselli PL, Garattini S. Monosodium glutamate and the Chinese restaurant syndrome. Nature 1970;227:611-2.

5. Zanda G, Franciosi P, Tognoni G, et al. A double blind study on the effects of monosodium glutamate in man. Biomedicine 1973;19:202-4.

6. Tung TC, Tung KS. Serum free amino acid levels after oral glutamate intake in infants and human adults. Nutr Rep Int 1980;22:431-43.

7. Schaumburg HH, Byck R, Gerstl R, Mashman JH. Monosodium L-glutamate: its pharmacology and role in the Chinese restaurant syndrome. Science 1969;163:826-8.

8. Rosenblum I, Bradley JD, Coulston F. Single and double blind studies with oral monosodium glutamate in man. Toxicol Appl Pharmacol 1971;18:367-73.

9. Kenney RA, Tidball CS. Human susceptibility to oral monosodium L-glutamate. Am J Clin Nutr 1972;25:140-6.

10. Walker R, Lupien JR. The safety evaluation of monosodium glutamate. J Nutr 2000;130(4S Suppl):1049-52S [review].

11. Geha R, Beiser A, Ren C, et al. Multicenter multiphase double-blind placebo controlled study to evaluate alleged reactions to monosodium glutamate (MSG). J Allergy Clin Immunol 1998;101:S243 [abstract].

12. Geha RS, Beiser A, Ren C, et al. Review of alleged reaction to monosodium glutamate and outcome of a multicenter double-blind placebo-controlled study. J Nutr 2000;130(4S Suppl):1058-62S [review].

13. Stegink LD, Filer LJ Jr, Baker GL. Effect of aspartame and sucrose loading in glutamate-susceptible subjects. Am J Clin Nutr 1981;34:1899-905.

14. Wen CP, Gershoff SN. Effects of dietary vitamin B6 on the utilization of monosodium glutamate by rats. J Nutr 1972;102:835-40.

15. Folkers K, Shizukuishi S, Scudder SL, et al. Biochemical evidence for a deficiency of vitamin B6 in subjects reacting to monosodium-L-glutamate by the Chinese restaurant syndrome. Biochem Biophys Res Commun 1981;100:972-7.

Copyright © 2024 TraceGains, Inc. All rights reserved.

Learn more about TraceGains, the company.

The information presented by TraceGains is for informational purposes only. It is based on scientific studies (human, animal, or in vitro), clinical experience, or traditional usage as cited in each article. The results reported may not necessarily occur in all individuals. Self-treatment is not recommended for life-threatening conditions that require medical treatment under a doctor's care. For many of the conditions discussed, treatment with prescription or over the counter medication is also available. Consult your doctor, practitioner, and/or pharmacist for any health problem and before using any supplements or before making any changes in prescribed medications. Information expires December 2024.

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