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Health Condition

Male Infertility

About This Condition

Infertility is defined by doctors as the failure of a couple to achieve pregnancy after a year of unprotected intercourse.

In men, infertility is usually associated with a decrease in the number, quality, or motility (power of movement) of sperm. There are multiple possible underlying causes for male infertility, some of which readily respond to natural medicine, while others do not. The specific cause of infertility should always be diagnosed by a physician before considering possible solutions.

Symptoms

The inability of a couple to become pregnant after one year of regular, unprotected sex may indicate infertility of one or both sexual partners. Low sperm count in the semen, decreased sperm motility, or abnormal shape of the sperm are responsible for infertility in about 40% of these couples.

Other Therapies

Initial treatments may include timing sexual activity for ovulation (usually during the second week of the menstrual cycle), avoiding drugs that may reduce sperm count, and limiting intercourse to no more than once every three days, except during ovulation. Artificial insemination can also be used to place sperm directly in the cervix or uterus. Another more advanced procedure is called “in vitro fertilization” (IVF), wherein the man’s sperm and the woman’s egg (collected from the ovary in a surgical procedure) are combined under controlled conditions in a laboratory. The fertilized embryo is then implanted into the woman’s uterus. The injectable drug follitropin alfa (Gonal-f) may be beneficial in certain situations. Clomiphene (Clomid), though controversial, and anastrozole (Arimidex) might also improve fertility in some men.

References

1. Prasad AS, Cossack ZT. Zinc supplementation and growth in sickle cell disease. Ann Intern Med 1984;100:367-71.

2. Kvist U, Kjellberg S, Bjorndahl L, et al. Seminal fluid from men with agenesis of the Wolffian ducts: zinc-binding properties and effects on sperm chromatin stability. Int J Androl 1990;13:245-52.

3. Saaranen M, Suistomaa U, Kantola M, et al. Lead, magnesium, selenium and zinc in human seminal fluid: comparison with semen parameters and fertility. Hum Reprod 1987;2:475-9.

4. Danscher G, Hammen R, Fjerdingstad E, Rebbe H. Zinc content of human ejaculate and motility of sperm cells. Int J Androl 1978;1:576-81.

5. Carpino A, Siciliano L, Petroni MF, et al. Low seminal zinc bound to high molecular weight proteins in asthenozoospermic patients: evidence of increased sperm zinc content in oligoasthenozoospermic patients. Hum Reprod 1998;13:111-4.

6. Stankovic H, Mikac-Devic D. Zinc and copper in human semen. Clin Chim Acta 1976;70:123-6.

7. Hartoma TR, Nahoul K, Netter A. Zinc, plasma androgens and male sterility. Lancet 1977;2:1125-6.

8. Kynaston HG, Lewis-Jones DI, Lynch RV, Desmond AD. Changes in seminal quality following oral zinc therapy. Andrologia 1988;20:21-2.

9. Tikkiwal M, Ajmera RL, Mathur NK. Effect of zinc administration on seminal zinc and fertility of oligospermic males. Indian J Physiol Pharmacol 1987;31:30-4.

10. Marmar JL, Katz S, Praiss DE, DeBenedictis TJ. Semen zinc levels in infertile and postvasectomy patients and patients with prostatitis. Fertil Steril 1975;26:1057-63.

11. Omu AE, Dashti H, Al-Othman S. Treatment of asthenozoospermia with zinc sulphate: andrological, immunological and obstetric outcome. Eur J Obstet Gynecol Reprod Biol 1998;79:179-84.

12. De Aloysio D, Mantuano R, Mauloni M, Nicoletti G. The clinical use of arginine aspartate in male infertility. Acta Eur Fertil 1982;13:133-67.

13. Tanimura J. Studies on arginine in human semen. Part II. The effects of medication with L-arginine-HCl on male infertility. Bull Osaka Med School 1967;13:84-9.

14. Scibona M, Meschini P, Capparelli S, et al. L-arginine and male infertility. Minerva Urol Nefrol 1994;46:251-3.

15. Schacter A, Goldman JA, Zukerman Z. Treatment of oligospermia with the amino acid arginine. J Urol 1973;110:311-3.

16. Schacter A, Friedman S, Goldman JA, Eckerling B. Treatment of oligospermia with the amino acid arginine. Int J Gynaecol Obstet 1973;11:206-9.

17. Mroueh A. Effect of arginine on oligospermia. Fertil Steril 1970:21:217-9.

18. Pryor JP, Blandy JP, Evans P, et al. Controlled clinical trial of arginine for infertile men with oligozoospermia. Br J Urol 1978;50:47-50.

19. Aydin S, Inci O, Alagol B. The role of arginine, indomethacin and kallikrein in the treatment of oligoasthenospermia. Int Urol Nephrol 1995;27:199-202.

20. Salvati G, Genovesi G, Marcellini L, et al. Effects of Panax ginseng C.A. Meyer saponins on male fertility. Panmineva Med 1996;38:249-54.

21. Comhaire FH, Mahmoud A. The role of food supplements in the treatment of the infertile man. Reprod Biomed Online 2003;7:385-91 [review].

22. Costa M, Canale D, Filicori M, et al. L-carnitine in idiopathic asthenozoospermia: a multicenter study. Andrologia 1994;26:155-9.

23. Vitali G, Parente R, Melotti C. Carnitine supplementation in human idiopathic asthenospermia: clinical results. Drugs Exp Clin Res 1995;21:157-9.

24. Moncada ML, Vicari E, Cimino C, et al. Effect of acetylcarnitine treatment in oligoasthenospermic patients. Acta Europaea Fertilitatis 1992;23:221-4.

25. Gonzales GF, Cordova A, Gonzales C, et al. Lepidium meyenii (maca) improved semen parameters in adult men. Asian J Androl 2001;3:301-3.

26. Scott R, MacPherson A, Yates RWS, et al. The effect of oral selenium supplementation on human sperm motility. Br J Urol 1998;82:76-80.

27. Sandler B, Faragher B. Treatment of oligospermia with vitamin B12. Infertility 1984;7:133-8.

28. Kumamoto Y, Maruta H, Ishigami J, et al. Clinical efficacy of mecobalamin in treatment of oligozoospermia. Acta Urol Jpn 1988;34:1109-32.

29. Isoyama R, Baba Y, Harada H, et al. Clinical experience of methyl-cobalamin (CH3-B12)/clomiphene citrate combined treatment in male infertility. Hinyokika Kiyo 1986;32:1177-83 [in Japanese].

30. Costa M, Canale D, Filicori M, et al. L-carnitine in idiopathic asthenozoospermia: a multicenter study. Andrologia 1994;26:155-9.

31. Vitali G, Parente R, Melotti C. Carnitine supplementation in human idiopathic asthenospermia: clinical results. Drugs Exp Clin Res 1995;21:157-9.

32. Moncada ML, Vicari E, Cimino C, et al. Effect of acetylcarnitine treatment in oligoasthenospermic patients. Acta Europaea Fertilitatis 1992;23:221-4.

33. Tanimura J. Studies on arginine in human semen. Part III. The influences of several drugs on male infertility. Bull Osaka Med School 1967;13:90-100.

34. Lewin A, Lavon H. The effect of coenzyme Q10 on sperm motility and function. Mol Aspects Med 1997;18 Suppl:S213-9.

35. Piacentino R, Malara D, Zaccheo F, et al. Preliminary study of the use of s. adenosyl methionine in the management of male sterility. Minerva Ginecologica 1991;43:191-3 [in Italian].

36. Thiessen DD, Ondrusek G, Coleman RV. Vitamin E and sex behavior in mice. Nutr Metab 1975;18:116-9.

37. Bayer R. Treatment of infertility with vitamin E. Int J Fertil 1960;5:70-8.

38. Geva E, Bartoov B, Zabludovsky N, et al. The effect of antioxidant treatment on human spermatozoa and fertilization rate in an in vitro fertilization program. Fertil Steril 1996;66:430-4.

39. Martin-Du Pan RC, Sakkas D. Is antioxidant therapy a promising strategy to improve human reproduction? Are anti-oxidants useful in the treatment of male infertility? Hum Reprod 1998;13:2984-5.

40. Siterman S, Eltes F, Wolfson V, et al. Effect of acupuncture on sperm parameters of males suffering from subfertility related to low sperm quality. Arch Androl 1997;39:155-61.

41. Riegler R, Fischl F, Bunzel B, Neumark J. Correlation of psychological changes and spermiogram improvements following acupuncture. Urologe [A] 1984;23:329-33 [in German].

42. Fischl F, Riegler R, Bieglmayer C, et al. Modification of semen quality by acupuncture in subfertile males. Geburtshilfe Fraunheilkd 1984;44:510-2 [in German].

43. Goverde HJM, Dekker HS, Janssen HJG, et al. Semen quality and frequency of smoking and alcohol consumption - an explorative study. Int J Fertil 1995;40:135-8.

44. Abell A, Ernst E, Bonde JP. High sperm density among members of organic farmers' association. Lancet 1994;343:1498.

45. Hruska KS, Furth PA, Seifer DB, et al. Environmental factors in infertility. Clin Obstet Gynecol 2000;43:821-9.

46. Wang SL, Wang XR, Chia SE, et al. A study on occupational exposure to petrochemicals and smoking on seminal quality. J Androl 2001;22:73-8.

47. Zhang JP, Meng QY, Wang Q, et al. Effect of smoking on semen quality of infertile men in Shandong, China. Asian J Androl 2000;2:143-6.

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The information presented by Healthnotes is for informational purposes only. It is based on scientific studies (human, animal, or in vitro), clinical experience, or traditional usage as cited in each article. The results reported may not necessarily occur in all individuals. Self-treatment is not recommended for life-threatening conditions that require medical treatment under a doctor's care. For many of the conditions discussed, treatment with prescription or over the counter medication is also available. Consult your doctor, practitioner, and/or pharmacist for any health problem and before using any supplements or before making any changes in prescribed medications. Information expires December 2018.