Health Condition

Insulin Resistance Syndrome

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Obesity, especially when fat accumulates in the abdominal region, increases the severity of insulin resistance,51,52 and has been associated with IRS.53,54 Loss of excess weight tends to improve insulin sensitivity (i.e., reduce insulin resistance),55,56 and this has been recently shown to be true for people with IRS as well.57 Weight loss also reduces many of the other health risk factors associated with IRS.58

Cigarette smoking, in most,59,60 though not all,61 studies, as well as exposure to secondhand smoke61 and use of nicotine replacement products,63,64 have been associated with insulin resistance. Smoking cessation has been shown to increase insulin sensitivity in healthy people.65

Alcohol consumption in the light to moderate range (up to 1 drink per day for women and up to 2 drinks per day for men66) is associated with better insulin sensitivity in healthy, nondiabetic people.67,68,69,70 Since alcohol consumption also reduces other risk factors for heart disease,71,72 it does not appear that people with IRS would benefit from avoiding alcohol if they are currently light to moderate drinkers. However, alcohol is potentially addicting and can increase the risk of other diseases, so people with IRS who are not users of alcohol should consult a doctor before starting regular consumption of alcoholic beverages.

Either aerobic exercise or strength training improves insulin sensitivity in both healthy and insulin-resistant people in most studies, 73,74 though a recent controlled trial found that aerobic exercise alone did not affect insulin resistance in people with IRS.57 Studies comparing strength training to aerobic exercise in insulin-resistant people have reported greater benefits from strength training,76,77 but a combination of the two will probably be more effective than either one alone. Current recommendations for exercise includes about 30 minutes per day of moderate-intensity aerobic exercise and muscle strengthening exercises (working all major muscle groups) at least two days per week.78,73,80 In addition, exercise has many benefits in reducing many of the risk factors associated with IRS.80

Some popular diet books claim that insulin resistance causes weight gain and prevents successful weight loss. However, one controlled study found no difference in the number of women experiencing successful short-term weight loss between women with or without insulin resistance.82

Insulin sensitivity decreases after certain stressful experiences, such as surgery,83 and decreased insulin sensitivity is associated with work-related mental and emotional stress,84 and other aspects of a stressful lifestyle.85 However, these associations have not been explored in people with IRS, nor has stress reduction been investigated as a treatment for IRS.


1. Lempiainen P, Mykkanen L, Pyorala K, et al. Insulin resistance syndrome predicts coronary heart disease events in elderly nondiabetic men. Circulation 1999;100:123-8.

2. Vanhala MJ, Pitkajarvi TK, Kumpusalo EA, Takala JK. Obesity type and clustering of insulin resistance-associated cardiovascular risk factors in middle-aged men and women. Int J Obes Relat Metab Disord 1998;22:369-74.

3. Yip J, Facchini FS, Reaven GM. Resistance to insulin-mediated glucose disposal as a predictor of cardiovascular disease. J Clin Endocrinol Metab 1998;83:2773-6.

4. Pyorala M, Miettinen H, Halonen P, et al. Insulin resistance syndrome predicts the risk of coronary heart disease and stroke in healthy middle-aged men: the 22-year follow-up results of the Helsinki Policemen Study. Arterioscler Thromb Vasc Biol 2000;20:538-44.

5. Moore MA, Park CB, Tsuda H. Implications of the hyperinsulinaemia-diabetes-cancer link for preventive efforts. Eur J Cancer Prev 1998;7:89-107 [review].

6. Stoll BA. Western nutrition and the insulin resistance syndrome: a link to breast cancer. Eur J Clin Nutr 1999;53:83-7 [review].

7. Liese AD, Mayer-Davis EJ, Haffner SM. Development of the insulin resistance syndrome: an epidemiologic perspective. Epidemiol Rev 1998;20:157-72.

8. Trevisan M, Liu J, Bahsas FB, Menotti A. Syndrome X and mortality: a population-based study. Am J Epidemiol 1998;148:958-66.

9. Valdez R. Epidemiology. Nutr Rev 2000;58:S4-S6 [review].

10. Vuksan V, Sievenpiper JL, Owen R, et al. Beneficial effects of viscous dietary fiber from Konjac-mannan in subjects with the insulin resistance syndrome: results of a controlled metabolic trial. Diabetes Care 2000;23:9-14.

11. Landin K, Holm G, Tengborn L, Smith U. Guar gum improves insulin sensitivity, blood lipids, blood pressure, and fibrinolysis in healthy men. Am J Clin Nutr 1992;56:1061-5.

12. Cavallo-Perin P, Bruno A, Nuccio P, et al. Dietary guar gum supplementation does not modify insulin resistance in gross obesity. Acta Diabetol Lat 1985;22:139-142.

13. Mertz W. Chromium in human nutrition: a review. J Nutr 1993;123:626-33 [review].

14. Anderson RA. Chromium, glucose intolerance and diabetes. J Am Coll Nutr 1998;17:548-55 [review].

15. Vincent JB. Mechanisms of chromium action: low-molecular-weight chromium-binding substance. J Am Coll Nutr 1999;18:6-12 [review].

16. Anderson RA. Nutritional factors influencing the glucose/insulin system: chromium. J Am Coll Nutr 1997;16:404-10 [review].

17. Morris BW, MacNeil S, Stanley K, et al. The inter-relationship between insulin and chromium in hyperinsulinaemic euglycaemic clamps in healthy volunteers. J Endocrinol 1993;139:339-45.

18. Vuksan V, Sievenpiper JL, Owen R, et al. Beneficial effects of viscous dietary fiber from Konjac-mannan in subjects with the insulin resistance syndrome: results of a controlled metabolic trial. Diabetes Care 2000;23:9-14.

19. Landin K, Holm G, Tengborn L, Smith U. Guar gum improves insulin sensitivity, blood lipids, blood pressure, and fibrinolysis in healthy men. Am J Clin Nutr 1992;56:1061-5.

20. Cavallo-Perin P, Bruno A, Nuccio P, et al. Dietary guar gum supplementation does not modify insulin resistance in gross obesity. Acta Diabetol Lat 1985;22:139-142.

21. Sanchez M, de la Sierra A, Coca A, Oral calcium supplementation reduces intraplatelet free calcium concentration and insulin resistance in essential hypertensive patients. Hypertension 1997;29:531-6.

22. Singh RB, Niaz MA, Rastogi SS, et al. Effect of hydrosoluble coenzyme Q10 on blood pressures and insulin resistance in hypertensive patients with coronary artery disease. J Hum Hypertens 1999;13:203-8.

23. Nadler JL, Buchanan T, Natarajan R, et al. Magnesium deficiency produces insulin resistance and increased thromboxane synthesis. Hypertension 1993;21:1024-9.

24. Humphries S, Kushner H, Falkner B. Low dietary magnesium is associated with insulin resistance in a sample of young, nondiabetic Black Americans. Am J Hypertens 1999;12:747-56.

25. Rosolova H, Mayer O Jr, Reaven G. Effect of variations in plasma magnesium concentration on resistance to insulin-mediated glucose disposal in nondiabetic subjects. J Clin Endocrinol Metab 1997;82:3783-5.

26. Paolisso G, Di Maro G, Galzerano D, et al. Pharmacological doses of vitamin E and insulin action in elderly subjects. Am J Clin Nutr 1994;59:1291-6.

27. Barbagallo M, Dominguez LJ, Tagliamonte MR, et al. Effects of vitamin E and glutathione on glucose metabolism: role of magnesium. Hypertension 1999;34:1002-6.

28. Singh RB, Niaz MA, Rastogi SS, et al. Current zinc intake and risk of diabetes and coronary artery disease and factors associated with insulin resistance in rural and urban populations of North India. J Am Coll Nutr 1998;17:564-70.

29. Chen MD, Lin PY, Lin WH. Investigation of the relationships between zinc and obesity. Kao Hsiung I Hsueh Ko Hsueh Tsa Chih 1991;7:628-34 [in Chinese].

30. Baba NH, Sawaya S, Torbay N, et al. High protein vs high carbohydrate hypoenergetic diet for the treatment of obese hyperinsulinemic subjects. Int J Obes Relat Metab Disord 1999;23:1202-6.

31. Wolfe BM. Potential role of raising dietary protein intake for reducing risk of atherosclerosis. Can J Cardiol 1995;11:127G-131G.

32. Wolfe BM, Piche LA. Replacement of carbohydrate by protein in a conventional-fat diet reduces cholesterol and triglyceride concentrations in healthy normolipidemic subjects. Clin Invest Med 1999;22:140-8.

33. Purnell JQ, Brunzell JD. The central role of dietary fat, not carbohydrate, in the insulin resistance syndrome. Curr Opin Lipidol 1997;8:17-22 [review].

34. Marshall JA, Bessesen DH, Hamman RF. High saturated fat and low starch and fibre are associated with hyperinsulinaemia in a non-diabetic population: the San Luis Valley Diabetes Study. Diabetologia 1997;40:430-8.

35. Feskens EJ, Loeber JG, Kromhout D. Diet and physical activity as determinants of hyperinsulinemia: the Zutphen Elderly Study. Am J Epidemiol 1994 15;140:350-60.

36. Daly ME, Vale C, Walker M, et al. Dietary carbohydrates and insulin sensitivity: a review of the evidence and clinical implications. Am J Clin Nutr 1997;66:1072-85 [review].

37. Daly ME, Vale C, Walker M, et al. Acute effects on insulin sensitivity and diurnal metabolic profiles of a high-sucrose compared with a high-starch diet. Am J Clin Nutr 1998;67:1186-96.

38. Wolever TM. Dietary carbohydrates and insulin action in humans. Br J Nutr 2000;83:S97-S102 [review].

39. Mathers JC, Daly ME. Dietary carbohydrates and insulin sensitivity. Curr Opin Clin Nutr Metab Care 1998;1:553-7 [review].

40. Frost G, Leeds A, Trew G, et al. Insulin sensitivity in women at risk of coronary heart disease and the effect of a low glycemic diet. Metabolism 1998;47:1245-51.

41. Kiens B, Richter EA. Types of carbohydrate in an ordinary diet affect insulin action and muscle substrates in humans. Am J Clin Nutr 1996;63:47-53.

42. Jenkins DJ, Axelsen M, Kendall CW, et al. Dietary fibre, lente carbohydrates and the insulin-resistant diseases. Br J Nutr 2000;83:S157-S163 [review].

43. Barnard RJ, Wen SJ. Exercise and diet in the prevention and control of the metabolic syndrome. Sports Med 1994;18:218-28 [review].

44. Storlien LH, Kriketos AD, Calvert GD, et al. Fatty acids, triglycerides and syndromes of insulin resistance. Prostaglandins Leukot Essent Fatty Acids 1997;57:379-85 [review].

45. Riccardi G, Rivellese AA. Dietary treatment of the metabolic syndrome—the optimal diet. Br J Nutr 2000;83:S143-S148 [review].

46. Torjesen PA, Birkeland KI, Anderssen SA, et al. Lifestyle changes may reverse development of the insulin resistance syndrome. The Oslo Diet and Exercise Study: a randomized trial. Diabetes Care 1997;20:26-31.

47. Anderssen SA, Hjermann I, Urdal P, et al. Improved carbohydrate metabolism after physical training and dietary intervention in individuals with the “atherothrombogenic syndrome.” Oslo Diet and Exercise Study (ODES). A randomized trial. J Intern Med 1996;240:203-9.

48. Reaven GM. Do high carbohydrate diets prevent the development or attenuate the manifestations (or both) of syndrome X? A viewpoint strongly against. Curr Opin Lipidol 1997;8:23-7 [review].

49. Connor WE, Connor SL. Should a low-fat, high-carbohydrate diet be recommended for everyone? The case for a low-fat, high-carbohydrate diet. N Engl J Med 1997;337:562-3 [editorial].

50. Williams DE, Prevost AT, Whichelow MJ, et al. A cross-sectional study of dietary patterns with glucose intolerance and other features of the metabolic syndrome. Br J Nutr 2000;83:257-66.

51. Belfiore F, Iannello S. Insulin resistance in obesity: metabolic mechanisms and measurement methods. Mol Genet Metab 1998;65:121-8.

52. Frayn KN. Visceral fat and insulin resistance—causative or correlative? Br J Nutr 2000;83:S71-7 [review].

53. Haffner SM. Obesity and the metabolic syndrome: the San Antonio Heart Study. Br J Nutr 2000;83:S67-70.

54. Okosun IS, Liao Y, Rotimi CN, et al. Abdominal adiposity and clustering of multiple metabolic syndrome in white, black and hispanic americans. Ann Epidemiol 2000;10:263-70.

55. Ross R, Dagnone D, Jones PJ, et al. Reduction in obesity and related comorbid conditions after diet-induced weight loss or exercise-induced weight loss in men. A randomized, controlled trial. Ann Intern Med 2000;133:92-103.

56. Bessesen DH. Obesity as a factor. Nutr Rev 2000;58:S12-S15 [review].

57. Torjesen PA, Birkeland KI, Anderssen SA, et al. Lifestyle changes may reverse development of the insulin resistance syndrome. The Oslo Diet and Exercise Study: a randomized trial. Diabetes Care 1997;20:26-31.

58. Grundy SM. Hypertriglyceridemia, insulin resistance, and the metabolic syndrome. Am J Cardiol 1999;83:25F-29F [review].

59. Tahtinen TM, Vanhala MJ, Oikarinen JA, Keinanen-Kiukaanniemi SM. Effect of smoking on the prevalence of insulin resistance-associated cardiovascular risk factors among Finnish men in military service. J Cardiovasc Risk 1998;5:319-23.

60. Mikhailidis DP, Papadakis JA, Ganotakis ES. Smoking, diabetes and hyperlipidaemia. J R Soc Health 1998;118:91-3 [review].

61. Henkin L, Zaccaro D, Haffner S, et al. Cigarette smoking, environmental tobacco smoke exposure and insulin sensitivity: the Insulin Resistance Atherosclerosis Study. Ann Epidemiol 1999;9:290-6.

62. Eliasson B, Taskinen MR, Smith U. Long-term use of nicotine gum is associated with hyperinsulinemia and insulin resistance. Circulation 1996;94:878-81.

63. Assali AR, Beigel Y, Schreibman R, et al. Weight gain and insulin resistance during nicotine replacement therapy. Clin Cardiol 1999;22:357-60.

64. Eliasson B, Attvall S, Taskinen MR, Smith U. Smoking cessation improves insulin sensitivity in healthy middle-aged men. Eur J Clin Invest 1997;27:450-6.

65. Alcohol and Public Health: What does moderate drinking mean? Centers for Disease Control and Prevention [last updated 2014 Mar 14, cited 2014 Jun 9]. Available from URL: www.cdc.gov/alcohol/faqs.htm#moderateDrinking.

66. Flanagan DE, Moore VM, Godsland IF, et al. Alcohol consumption and insulin resistance in young adults. Eur J Clin Invest 2000;30:297-301.

67. Kiechl S, Willeit J, Poewe W, et al. Insulin sensitivity and regular alcohol consumption: large, prospective, cross sectional population study Bruneck study. BMJ 1996;313:1040-4.

68. Mayer EJ, Newman B, Quesenberry CP Jr, et al. Alcohol consumption and insulin concentrations. Role of insulin in associations of alcohol intake with high-density lipoprotein cholesterol and triglycerides. Circulation 1993;88:2190-7.

69. Lazarus R, Sparrow D, Weiss ST. Alcohol intake and insulin levels. The Normative Aging Study. Am J Epidemiol 1997;145:909-16.

70. Rimm EB, Klatsky A, Grobbee D, Stampfer MJ. Review of moderate alcohol consumption and reduced risk of coronary heart disease: is the effect due to beer, wine, or spirits? BMJ 1996;312:731-6 [review].

71. Hendriks HF, Veenstra J, Velthuis-te Wierik EJ, et al. Effect of moderate dose of alcohol with evening meal on fibrinolytic factors. BMJ 1994;304:1003-6.

72. van Baak MA, Borghouts LB. Relationships with physical activity. Nutr Rev 2000;58:S16-S18 [review].

73. Borghouts LB, Keizer HA. Exercise and insulin sensitivity: a review. Int J Sports Med 2000;21:1-12 [review].

74. Eriksson J, Tuominen J, Valle T, et al. Aerobic endurance exercise or circuit-type resistance training for individuals with impaired glucose tolerance? Horm Metab Res 1998;30:37-41.

75. Smutok MA, Reece C, Kokkinos PF, et al. Effects of exercise training modality on glucose tolerance in men with abnormal glucose regulation. Int J Sports Med 1994;15:283-9.

76. How much physical activity do adults need? Centers for Disease Control and Prevention [last updated 2014 Mar 3, cited 2014 Jul 9]. Available from URL: http://www.cdc.gov/physicalactivity/everyone/guidelines/adults.html.

77. Eriksson J, Taimela S, Koivisto VA. Exercise and the metabolic syndrome. Diabetologia 1997;40:125-35 [review].

78. McLaughlin T, Abbasi F, Carantoni M, et al. Differences in insulin resistance do not predict weight loss in response to hypocaloric diets in healthy obese women. J Clin Endocrinol Metab 1999;84:578-81.

79. Brandi LS, Santoro D, Natali A, et al. Insulin resistance of stress: sites and mechanisms. Clin Sci (Colch) 1993;85:525-35.

80. Keltikangas-Jarvinen L, Ravaja N, Raikkonen K, et al. Relationships between the pituitary-adrenal hormones, insulin, and glucose in middle-aged men: moderating influence of psychosocial stress. Metabolism 1998;47:1440-9.

81. Raikkonen K, Keltikangas-Jarvinen L, Adlercreutz H, Hautanen A. Psychosocial stress and the insulin resistance syndrome. Metabolism 1996;45:1533-8.

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Drugs used to treat INSULIN RESISTANCE SYNDROME. Select drug name to view medication information and pricing