Goiter

Health Condition

Goiter

The right diet is the key to managing many diseases and to improving general quality of life. For this condition, scientific research has found benefit in the following healthy eating tips.

  • Iodine

    Ask your healthcare provider if your goiter may be caused by too little or too much iodine in your body.
    Iodine
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    The most important dietary concern in treating iodine-deficiency hypothyroidism and preventing goiter is ensuring adequate intake of iodine. Iodine is found naturally in foods from the ocean, such as fish and seafood, kelp, and sea vegetables, and in plant and animal products produced in areas where soil and water contain sufficient iodine.31,32 In developed countries, commercial table salt has been fortified with iodine since the 1920s to prevent deficiency.33 Iodized salt contains approximately 100 micrograms of iodine per gram of salt. This fortified salt is used directly and is incorporated into animal feeds and processed foods making it easy to achieve the Recommended Dietary Allowance (RDA) of 150 mcg for adolescents and adults and 200 mcg daily for pregnant and breast-feeding women.33 Iodized salt has proven so effective it is recommended as the intervention of choice to eliminate iodine deficiency worldwide.35,36 Iodized oils, given as an annual injection or as food orally, have also been used effectively to treat iodine-deficiency goiter.37,38

    Although iodine deficiency and goiter are now quite uncommon in developed countries, recent studies have found that the average dietary iodine intake in the United States has fallen below RDA guidelines.33 Long-term excessive dietary intake of iodine (1,000 to 2,000 micrograms daily), while less common than iodine deficiency, can occur in people who eat large amounts of kelp and other sea vegetables and can also cause goiter.40,41

    A number of commonly eaten foods have been shown to interfere with the use of iodine by the thyroid, thus reducing production of thyroid hormone and causing goiter. These foods, known as goitrogens, include vegetables in the Brassica family such as broccoli, cabbage, kale and mustard,42 millet,43 soybeans,44 pine nuts45 and some seed meals used in animal feeds.46,47 These foods can be safely eaten in moderate amounts by people who consume adequate iodine.48 A combination of low iodine intake and high intake of goitrogenic foods increases the likelihood of goiter.48,45

  • Eating Healthy

    Nutrient deficiencies, including zinc, manganese, and vitamin A, and severe protein malnutrition contribute to an inability to use iodine well and to goiter development.
    Eating Healthy
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    Nutrient deficiencies, including zinc,47manganese48 and vitamin A,49,50 and severe protein malnutrition49 also contribute to an inability to use iodine well and to the development of goiter.50,53 In the presence of adequate iodine supplies, it is less common for such factors to cause goiter;54,55 however, when iodine intake becomes deficient, even mild malnutrition can have such a negative impact on thyroid function.56,57 High levels of minerals such as calcium and magnesium, and certain bacteria in drinking water, have also been shown to be goitrogenic.53,59 Therefore, proper nutrition and a healthy water supply are crucial in the prevention and treatment of goiter.

References

1. Prescott E, Netterstrom B, Faber J, et al. Effect of occupational exposure to cobalt blue dyes on the thyroid volume and function of female plate painters. Scand J Work Environ Health 1992;18:101-4.

2. Gaitan E. Goitrogens. Baillieres Clin Endocrinol Metab 1988;2:683-702 [review].

3. Gaitan E. Goitrogens in food and water. Annu Rev Nutr 1990;10:21-39 [review].

4. Ingenbleek Y, De Visscher M. Hormonal and nutritional status: critical conditions for endemic goiter epidemiology? Metabolism 1979;28:9-19 [review].

5. Lamberg BA. Endemic goitre--iodine deficiency disorders. Ann Med 1991;23:367-72 [review].

6. Koutras DA. Iodine metabolism in endemic goitre. Ann Clin Res 1972;4:55-63 [review].

7. Lee K, Bradley R, Dwyer J, Lee S. Too much versus too little: The implications of current iodine intake in the United States. Nutr Rev 1999;57:177-81 [review].

8. Cotran RS, Kumar V, Robbins SL. Robbins Pathologic Basis of Disease, 4th edition. Philadelphia: WB Saunders Co, 1989, 1227-8.

9. Gaitan E. Goitrogens in food and water. Annu Rev Nutr 1990;10:21-39 [review].

10. Wilson JD, Foster DW, Kronenberg HM, Larsen PR. Williams Textbook of Endocrinology, 9th edition. Philadelphia: WB Saunders Co, 1998, 469.

11. Ozata M, Salk M, Aydin A, et al. Iodine and zinc, but not selenium and copper, deficiency exists in a male Turkish population with endemic goiter. Biol Trace Elem Res 1999;69:211-6.

12. Kawada J, Nishida M, Yoshimura Y, Yamashita K. Manganese ion as a goitrogen in the female mouse. Endocrinol Jpn 1985;32:635-43.

13. Untoro J, Ruz M, Gross R. Low environmental selenium availability as an additional determinant for goiter in East Java, Indonesia? Biol Trace Elem Res 1999;70:127-36.

14. Corvilain B, Contempre B, Longombe AO, et al. Selenium and the thyroid: how the relationship was established. Am J Clin Nutr 1993;57:244S-248S [review].

15. Vanderpas JB, Contempre B, Duale NL, et al. Selenium deficiency mitigates hypothyroxinemia in iodine-deficient subjects. Am J Clin Nutr 1993 Feb;57(2 Suppl):271S-275S [review].

16. Roti E, Minelli R, Gardini E, et al. Selenium administration does not cause thyroid insufficiency in subjects with mild iodine deficiency and sufficient selenium intake. J Endocrinol Invest 1993;7:481-4.

17. Zimmermann MB, Adou P, Torresani T, et al. Effect of oral iodized oil on thyroid size and thyroid hormone metabolism in children with concurrent selenium and iodine deficiency. Eur J Clin Nutr 2000;3:209-13.

18. Keyvani F, Yassai M, Kimiagar M. Vitamin A status and endemic goiter. Int J Vitam Nutr Res 1988;58:155-60.

19. Mesaros-Kanjski E, Kontosic I, Kusic Z, et al. Endemic goitre and plasmatic levels of vitamins A and E in the school-children on the island of Krk, Croatia. Coll Antropol 1999;23:729-36.

20. Mutaku JF, Many MC, Colin I, et al. Antigoitrogenic effect of combined supplementation with dl-alpha-tocopherol, ascorbic acid and beta-carotene and of dl-alpha-tocopherol alone in the rat. J Endocrinol 1998;156:551-61.

21. Keyvani F, Yassai M, Kimiagar M. Vitamin A status and endemic goiter. Int J Vitam Nutr Res 1988;58:155-60.

22. Mesaros-Kanjski E, Kontosic I, Kusic Z, et al. Endemic goitre and plasmatic levels of vitamins A and E in the school-children on the island of Krk, Croatia. Coll Antropol 1999;23:729-36.

23. Mutaku JF, Many MC, Colin I, et al. Antigoitrogenic effect of combined supplementation with dl-alpha-tocopherol, ascorbic acid and beta-carotene and of dl-alpha-tocopherol alone in the rat. J Endocrinol 1998;156:551-61.

24. Ozata M, Salk M, Aydin A, et al. Iodine and zinc, but not selenium and copper, deficiency exists in a male Turkish population with endemic goiter. Biol Trace Elem Res 1999;69:211-6.

25. Kawada J, Nishida M, Yoshimura Y, Yamashita K. Manganese ion as a goitrogen in the female mouse. Endocrinol Jpn 1985;32:635-43.

26. Untoro J, Ruz M, Gross R. Low environmental selenium availability as an additional determinant for goiter in East Java, Indonesia? Biol Trace Elem Res 1999;70:127-36.

27. Corvilain B, Contempre B, Longombe AO, et al. Selenium and the thyroid: how the relationship was established. Am J Clin Nutr 1993;57:244S-248S [review].

28. Vanderpas JB, Contempre B, Duale NL, et al. Selenium deficiency mitigates hypothyroxinemia in iodine-deficient subjects. Am J Clin Nutr 1993 Feb;57(2 Suppl):271S-275S [review].

29. Roti E, Minelli R, Gardini E, et al. Selenium administration does not cause thyroid insufficiency in subjects with mild iodine deficiency and sufficient selenium intake. J Endocrinol Invest 1993;7:481-4.

30. Zimmermann MB, Adou P, Torresani T, et al. Effect of oral iodized oil on thyroid size and thyroid hormone metabolism in children with concurrent selenium and iodine deficiency. Eur J Clin Nutr 2000;3:209-13.

31. Lamberg BA. Iodine deficiency disorders and endemic goitre. Eur J Clin Nutr 1993;47:1-8 [review].

32. Koutras DA. Iodine metabolism in endemic goitre. Ann Clin Res 1972;4:55-63 [review].

33. Lee K, Bradley R, Dwyer J, Lee S. Too much versus too little: The implications of current iodine intake in the United States. Nutr Rev 1999;57:177-81 [review].

34. Lamberg BA. Endemic goitre--iodine deficiency disorders. Ann Med 1991;23:367-72 [review].

35. Dunn JT. Seven deadly sins in confronting endemic iodine deficiency, and how to avoid them. J Clin Endocrinol Metab 1996;81:1332-5 [review].

36. Ingenbleek Y, Jung L, Ferard G. Brassiodol, a new iodised oil for goitrous patients. Coll Antropol 1998;22:51-62.

37. Untoro J, Schultink W, Gross R, et al. Efficacy of different types of iodised oil. Lancet 1998;351:752-3.

38. Franceschi S, Talamini R, Fassina A, Bidoli E. Diet and epithelial cancer of the thyroid gland. Tumori 1990;76:331-8 [review].

39. Wilson JD, Foster DW, Kronenberg HM, Larsen PR. Williams Textbook of Endocrinology, 9th edition. Philadelphia: WB Saunders Co, 1998, 469.

40. Stoewsand GS. Bioactive organosulfur phytochemicals in Brassica oleracea vegetables—a review. Food Chem Toxicol 1995;33:537-43 [review].

41. Sartelet H, Serghat S, Lobstein A, et al. Flavonoids extracted from fonio millet (Digitaria exilis) reveal potent antithyroid properties. Nutrition 1996;12:100-6.

42. Divi RL, Chang HC, Doerge DR. Anti-thyroid isoflavones from soybean: isolation, characterization and mechanisms of action. Biochem Pharmacol 1997;54:1087-96.

43. Gaitan E. Goitrogens in food and water. Annu Rev Nutr 1990;10:21-39 [review].

44. Mawson R, Heaney RK, Zdunczyk Z, Kozlowska H. Rapeseed meal-glucosinolates and their antinutritional effects. Part 4. Goitrogenicity and internal organs abnormalities in animals. Nahrung 1994;38:178-91.

45. Bell JM. Nutrients and toxicants in rapeseed meal: a review. J Anim Sci 1984;58:996-1010 [review].

46. Gaitan E. Goitrogens. Baillieres Clin Endocrinol Metab 1988;2:683-702 [review].

47. Ozata M, Salk M, Aydin A, et al. Iodine and zinc, but not selenium and copper, deficiency exists in a male Turkish population with endemic goiter. Biol Trace Elem Res 1999;69:211-6.

48. Kawada J, Nishida M, Yoshimura Y, Yamashita K. Manganese ion as a goitrogen in the female mouse. Endocrinol Jpn 1985;32:635-43.

49. Ingenbleek Y, Luypaert B, De Nayer P. Nutritional status and endemic goitre. Lancet 1980;1:388-91.

50. Osman AK, Fatah AA. Factors other than iodine deficiency contributing to the endemicity of goitre in Darfur Province (Sudan). J Hum Nutr 1981;35:302-9.

51. Gaur DR, Sood AK, Gupta VP. Goitre in school girls of the Mewat area of Haryana. Indian Pediatr 1989;26:223-7.

52. Gaitan E. Goitrogens. Baillieres Clin Endocrinol Metab 1988;2:683-702 [review].

53. Lamberg BA. Endemic goitre--iodine deficiency disorders. Ann Med 1991;23:367-72 [review].

54. Centanni M, Maiani G, Vermiglio F, et al. Combined impairment of nutritional parameters and thyroid homeostasis in mildly iodine-deficient children. Thyroid 1998;8:155-9.

55. Filteau SM, Sullivan KR, Anwar US, et al. Iodine deficiency alone cannot account for goitre prevalence among pregnant women in Modhupur, Bangladesh. Eur J Clin Nutr 1994;48:293-302.

56. Gaitan E. Goitrogens in food and water. Annu Rev Nutr 1990;10:21-39 [review].

Copyright © 2024 TraceGains, Inc. All rights reserved.

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The information presented by TraceGains is for informational purposes only. It is based on scientific studies (human, animal, or in vitro), clinical experience, or traditional usage as cited in each article. The results reported may not necessarily occur in all individuals. Self-treatment is not recommended for life-threatening conditions that require medical treatment under a doctor's care. For many of the conditions discussed, treatment with prescription or over the counter medication is also available. Consult your doctor, practitioner, and/or pharmacist for any health problem and before using any supplements or before making any changes in prescribed medications. Information expires December 2024.

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