Health Condition


About This Condition

Epilepsy is a brain disorder in which abnormal bursts of electrical activity occur in cells of the brain, resulting in seizures.

There are many types of epilepsy, usually categorized by the symptoms that occur during seizures. The cause of many types of epilepsy is unknown, and frequently no cure is available. Rather, treatment focuses on reducing the frequency and severity of seizures.


There are many types of seizures in epilepsy. They are categorized as either partial or generalized, depending on how much of the brain is involved. Some types of epilepsy involve seizures characterized by convulsive muscle contractions of all or some parts of the body. Other types can involve momentary loss of consciousness, amnesia, unusual sensations or emotions, and other symptoms. Symptoms that indicate an imminent seizure (called auras) may occur. Similarly, non-convulsive symptoms, including deep sleep, headache, confusion, and muscle soreness (called a postictal state), may follow a generalized seizure.

Other Therapies

About 10 to 20% of epilepsy patients do not respond to drug therapy and may require surgery.


1. Schlanger S, Shinitzky M, Yam D. Diet enriched with omega-3 fatty acids alleviates convulsion symptoms in epilepsy patients. Epilepsia 2002;43:103-104.

2. Yuen AW, Sander JW, Fluegel D, et al. Omega-3 fatty acid supplementation in patients with chronic epilepsy: a randomized trial. Epilepsy Behav 2005;7:253–8.

3. DeGiorgio CM, Miller PR, Harper R, et al. Fish oil (n-3 fatty acids) in drug resistant epilepsy: a randomised placebo-controlled crossover study. J Neurol Neurosurg Psychiatry 2015;86:65–70.

4. Abdelmalik PA, Politzer N, Carlen PL. Magnesium as an effective adjunct therapy for drug resistant seizures. <em>Can J Neurol Sci</em> 2012;39:323-7.

5. Yarnell EY, Abascal K. An herbal formula for treating intractable epilepsy: a review of the literature. Alt Compl Ther 2000;6:203-6 [review].

6. Narita Y, Satowa H, Kokubu T, et al. Treatment of epileptic patients with the Chinese herbal medicine “saiko-keishi-to” (SK). IRCS Med Sci 1982;10:88-9.

7. Nagakubo S, Niwa S-I, Kumagai N, et al. Effects of TJ-960 on Sternberg's paradigm results in epileptic patients. Jpn J Psych Neur 1993;47:609-19.

8. Hollo A, Clemens Z, Kamondi A, et al. Correction of vitamin D deficiency improves seizure control in epilepsy: a pilot study. Epilepsy Behav 2012;24:131-3.

9. Mukherjee GD, Dey CD. Comparative study on the anti-epileptic action of some common phyto-products. J Exp Med Sci 1968;11:82-5.

10. Mukherjee GD, Dey CD. Clinical trial on Brahmi. J Exp Med Sci 1966;10:5-11.

11. Gibberd FB, Nicholls A, Wright MG. The influence of folic acid on the frequency of epileptic attacks. Eur J Clin Pharmacol 1981;19:57-60.

12. Guidolin L, Vignoli A, Canger R. Worsening in seizure frequency and severity in relation to folic acid administration. Eur J Neurol 1998;5:301-3.

13. Lewis DP, Van Dyke DC, Willhite LA. Phenytoin-folic acid interaction. Ann Pharmacother 1995;29:726-35 [review].

14. Berg MJ, Rivey MP, Vern BA, et al. Phenytoin and folic acid: individualized drug-drug interaction. Ther Drug Monit 1983;5:395-9.

15. Reynolds EH. Effects of folic acid on the mental state and fit frequency of drug treated epileptic patients. Lancet 1967;1:1086.

16. Eros E, Geher P, Gomor B, et al. Epileptogenic activity of folic acid after drug induces SLE (folic acid and epilepsy). Eur J Obstet Gynecol Reprod Biol 1998;80:75-8.

17. Ueda S, Shirakawa T, Nakazawa Y, et al. Epilepsy and folic acid. Folia Psychiatr Neurol Jpn 1977;31:327-37.

18. Fauteck J, Schmidt H, Lerchl A, et al. Melatonin in epilepsy: first results of replacement therapy and first clinical results. Biol Signals Recept 1999;8:105-10.

19. Durelli L, Mutani R. The current status of taurine in epilepsy. Clin Neuropharmacol 1983;6:37-48.

20. Bankier A, Turner M, Hopkins IJ. Pyridoxine dependent seizures—a wider clinical spectrum. Arch Dis Child 1983;58:415-8.

21. Baxter P, Griffiths P, Kelly T, et al. Pyridoxine-dependent seizures: demographic, clinical, MRI and psychometric features, and effect of dose on intelligence quotient. Develop Med Child Neurol 1996;38:998-1006.

22. Jiao FY, Gao DY, Takuma Y, et al. Randomized, controlled trial of high-dose intravenous pyridoxine in the treatment of recurrent seizures in children. Pediatr Neurol 1997;17:54-7.

23. Goutieres F, Aicardi J. Atypical presentation of pyridoxine-dependent seizures: a treatable cause of intractable epilepsy in infants. Ann Neurol 1985;17:117-20.

24. Kossoff EH, Krauss GL, McGrogan JR, Freeman JM. Efficacy of the Atkins diet as therapy for intractable epilepsy. Neurology 2003;61:1789-91.

25. Stevens H. Allergy and epilepsy. Epilepsia 1965;6:205-16 [review].

26. Campbell M. Neurologic manifestations of allergic disease. Ann Allergy 1973;31:485-98 [review].

27. Crayton JW, Stone T, Stein G. Epilepsy precipitated by food sensitivity: report of a case with double-blind placebo-controlled assessment. Clin Electroencephalogr 1981;12:192-8.

28. Cunningham AS. Allergy, immunodeficiency and epilepsy. Lancet 1975;11:975 [letter].

29. Egger J, Carter CM, Soothill JF, Wilson J. Oligoantigenic diet treatment of children with epilepsy and migraine. J Pediatr 1989;114:51-8.

30. Van Someren V, Robinson RO, McArdle B, Sturgeon N. Restricted diets for treatment of migraine. J Pediatr 1990;117:509-10 [letter].

31. Wilder RM. The effects of ketonemia on the course of epilepsy. Mayo Clinic Proc 1921;2:307-8.

32. Prasad AN, Stafstrom CF, Holmes GL. Alternative epilepsy therapies: the ketogenic diet, immunoglobulins, and steroids. Epilepsia 1996;37:S81-S95 [review].

33. Vining EP, Freemen JM, Ballaban-Gil K, et al. A multicenter study of the efficacy of the ketogenic diet. Arch Neurol 1998;55:1433-7.

34. Freeman JM, Vining EP, Pillas DJ, et al. The efficacy of the ketogenic diet-1998: a prospective evaluation of intervention in 150 children. Pediatrics 1998;102:1358-63.

35. Neelam GK, Koehler AN, McGhee B, et al. The ketogenic diet in refractory epilepsy: the experience of Children's Hospital of Pittsburgh. Clinical Pediatrics 2000;39:153-9.

36. Barborka CJ. Results of treatment by ketogenic diet in one hundred cases of epilepsy in adults. Assoc Res Nerv Ment Dis 1929;7:638-58.

37. Ballaban-Gil K, Callahan CM, O'Dell C, et al. The ketogenic diet in the treatment of intractable epilepsy in adults. Epilepsy 1996;37:92 [abstract].

38. Ballaban-Gil K, Callahan CM, O'Dell C, et al. Complications of the ketogenic diet. Epilepsia 1998;39:744-8.

39. Barron TF, Hunt SL. A review of the newer antiepileptic drugs and the ketogenic diet. Clin Pediatr (Phila) 1997;36:513-21.

40. Freeman JM, Kelly MT, Freeman JB. The epilepsy diet treatment. New York, NY: Demos, 1994.

41. Carroll J, Koenigsberger D. The ketogenic diet: a practical guide for caregivers. J Am Diet Assoc 1998;98:316-21.

42. http://www-leland.stanford.edu/group/ketodiet

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The information presented by TraceGains is for informational purposes only. It is based on scientific studies (human, animal, or in vitro), clinical experience, or traditional usage as cited in each article. The results reported may not necessarily occur in all individuals. Self-treatment is not recommended for life-threatening conditions that require medical treatment under a doctor's care. For many of the conditions discussed, treatment with prescription or over the counter medication is also available. Consult your doctor, practitioner, and/or pharmacist for any health problem and before using any supplements or before making any changes in prescribed medications. Information expires December 2020.