Health Condition

Dupuytren’s Contracture

About This Condition

In Dupuytren’s contracture, a fibrous tissue formation occurs in the palm of the hand that can cause the last two fingers to curl up.

The origin of this condition is not well understood.


Dupuytren’s contracture is initially noticed as a tender, small, hardened nodule on the palm of the hand. As it progresses, a cordlike band develops along the palm and finger, which causes the affected finger to stay in a semi-closed position.

Other Therapies

Advanced contractures are treated with surgery; however, the recurrence rate is relatively high. Severe cases might require amputation of the affected finger.


1. Jacob SW, Wood DC. Dimethyl sulfoxide (DMSO). Toxicology, pharmacology, and clinical experience. Am J Surg 1967;114:414-26.

2. Thomson GR. Treatment of Dupuytren's contracture with vitamin E. BMJ 1949;Dec 17:1382-3.

3. Richards HJ. Dupuytren's contracture treated with vitamin E. BMJ 1952;June 21:1328.

4. Kirk JE, Chieffi M. Tocopherol administration to patients with Dupuytren's contracture: effect on plasma tocopherol levels and degree of contracture. Pro Soc Exp Biol Med 1952;80:565 [review].