Dupuytren’s Contracture
DMSO
Supplemental dimethyl sulfoxide applied to the affected area may reduce pain by inhibiting transmission of pain messages, and may also soften the connective tissue.Dose:
Refer to label instructionsDMSODMSO applied to the affected area may reduce pain by inhibiting transmission of pain messages, and may also soften the abnormal connective tissue associated with disorders such as Dupuytren’s contracture, keloids, Peyronie’s disease, and scleroderma. Research on the use of topical DMSO to treat Dupuytren’s contracture remains preliminary and unproven.1
Vitamin E
Supplementing with vitamin E may improve Dupuytren’s contracture, although research on the topic has been conflicting.Dose:
Refer to label instructionsVitamin EMany decades ago, researchers investigated the effects of taking vitamin E to treat Dupuytren’s contracture. Several studies reported that taking 200–2,000 IU of vitamin E per day for several months was helpful.2 Other studies, however, did not find it useful.3 Overall, there are more positive trials than negative ones,4 although none of the published research is recent. Nonetheless, some doctors believe that a three-month trial using very high amounts of vitamin E (2,000 IU per day) is helpful in some cases.