Chronic Obstructive Pulmonary Disease

Health Condition

Chronic Obstructive Pulmonary Disease

About This Condition

Chronic obstructive pulmonary disease (COPD) refers to the combination of chronic bronchitis and emphysema, resulting in obstruction of airways and poor oxygen transport in the lungs, respectively.

Although chronic bronchitis and emphysema are distinct conditions, smokers and former smokers often have aspects of both. In chronic bronchitis, the linings of the bronchial tubes are inflamed and thickened, leading to a chronic, mucus-producing cough and shortness of breath. In emphysema, the alveoli (tiny air sacs in the lungs) are damaged, also leading to shortness of breath. COPD is generally irreversible and may even be fatal.

Symptoms

Symptoms of COPD develop gradually and may initially include shortness of breath during exertion, wheezing especially when exhaling, and frequent coughing that produces variable amounts of mucus. In more advanced stages, people may experience rapid changes in the ability to breathe, shortness of breath at rest, fatigue, depression, memory problems, confusion, and frequent waking during sleep.

Other Therapies

People with COPD should stop smoking and avoid secondhand smoke in order to slow the rate of lung function decline. Individuals with COPD should receive yearly pneumococcal (pneumonia) and flu vaccinations. Supplemental oxygen therapy and breathing rehabilitation programs are recommended in some situations. Severe cases might require lung volume reduction surgery or a lung transplant.

References

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2. Boman G, Backer U, Larsson S, et al. Oral acetylcysteine reduces exacerbation rate in chronic bronchitis: report of a trial organized by the Swedish Society for Pulmonary Diseases. Eur J Respir Dis 1983;64:405–15.

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4. Zheng JP, Wen FQ, Bai CX, et al. Twice daily N-acetyl cysteine 600 mg for exacerbations of chronic obstructive pulmonary disease (PANTHEON): a randomised, double-blind placebo-controlled trial. Lancet Respir Med 2014;2:187–94.

5. Tse HN, Raiteri L, Wong KY, et al. Benefits of high-dose N-acetylcysteine to exacerbation-prone patients with COPD. Chest. 2014;146:611–23.

6. Schermer T, Chavannes N, Dekhuijzen R, et al. Fluticasone and N-acetylcysteine in primary care patients with COPD or chronic bronchitis. Respir Med 2009;103:542–51.

7. Decramer M, Rutten-van Molken M, Dekhuijzen PN, et al. Effects of N-acetylcysteine on outcomes in chronic obstructive pulmonary disease (Bronchitis Randomized on NAC Cost-Utility Study, BRONCUS): a randomised placebo-controlled trial. Lancet 2005;365:1552–60.

8. Fuld JP, Kilduff LP, Neder JA, et al. Creatine supplementation during pulmonary rehabilitation in chronic obstructive pulmonary disease. Thorax 2005;60:531–7.

9. Meyer-Wegner J. Ivy versus ambroxol in chronic bronchitis. Zeits Allegemeinmed 1993;69:61–6 [in German].

10. Dal Negro R, Pomari G, Zoccatelli O, Turco P. L-carnitine and rehabilitative respiratory physiokinesitherapy: metabolic and ventilatory response in chronic respiratory insufficiency. Int J Clin Pharmacol Ther Toxicol 1986;24:453-6.

11. Dal Negro R, Turco P, Pomari C, De Conti F. Effects of L-carnitine on physical performance in chronic respiratory insufficiency. Int J Clin Pharmacol Ther Toxicol 1988;26:269-72.

12. Matthys H, Pliskevich DA, Bondarchuk OM, et al. Randomised, double-blind, placebo-controlled trial of EPs 7630 in adults with COPD. Respir Med 2013;10:691–701.

13. Hoffman D. The Herbal Handbook: A User's Guide to Medical Herbalism. Rochester, VT: Healing Arts Press, 1988, 67.

14. Boyd EM. Expectorants and respiratory tract fluid. Pharmacol Rev 1954;6:521-42 [review].

15. Fujimoto S, Kurihara N, Hirata K, Takeda T. Effects of coenzyme Q10 administration on pulmonary function and exercise performance in patients with chronic lung diseases. Clin Investig 1993;71(8 Suppl):S162-6.

16. Hoffman D. The Herbal Handbook: A User's Guide to Medical Herbalism. Rochester, VT: Healing Arts Press, 1988, 67.

17. Boyd EM. Expectorants and respiratory tract fluid. Pharmacol Rev 1954;6:521-42 [review].

18. Boyd EM. Expectorants and respiratory tract fluid. Pharmacol Rev 1954;6:521-42 [review].

19. Shahar E, Folsom AR, Melnick SL, et al. Dietary n-3 polyunsaturated fatty acids and smoking-related chronic obstructive pulmonary disease. Atherosclerosis Risk in Communities Study Investigators. N Engl J Med 1994;331:228-33.

20. Broekhuizen R, Wouters EFM, Creutzberg EC, et al. Polyunsaturated fatty acids improve exercise capacity in chronic obstructive pulmonary disease. Thorax 2005;60:376-82.

21. Shahar E, Folsom AR, Melnick SL, et al. Dietary n-3 polyunsaturated fatty acids and smoking-related chronic obstructive pulmonary disease. Atherosclerosis Risk in Communities Study Investigators. N Engl J Med 1994;331:228-33.

22. Broekhuizen R, Wouters EFM, Creutzberg EC, et al. Polyunsaturated fatty acids improve exercise capacity in chronic obstructive pulmonary disease. Thorax 2005;60:376-82.

23. Hoffman D. The Herbal Handbook: A User's Guide to Medical Herbalism. Rochester, VT: Healing Arts Press, 1988, 67.

24. Boyd EM. Expectorants and respiratory tract fluid. Pharmacol Rev 1954;6:521-42 [review].

25. Hoffman D. The Herbal Handbook: A User's Guide to Medical Herbalism. Rochester, VT: Healing Arts Press, 1988, 67.

26. Boyd EM. Expectorants and respiratory tract fluid. Pharmacol Rev 1954;6:521-42 [review].

27. Rolla G, Bucca C, Bugiani M, et al. Hypomagnesemia in chronic obstructive lung disease: effect of therapy. Magnesium Trace Elem 1990;9:132-6.

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29. Skorodin MS, Tenholder MF, Yetter B, et al. Magnesium sulfate in exacerbations of chronic obstructive pulmonary disease. Arch Intern Med 1995;155:496-500.

30. Okayama H, Aikawa T, Okayama M, et al. Bronchodilating effect of intravenous magnesium sulfate in bronchial asthma. JAMA 1987;257:1076-8.

31. Hoffman D. The Herbal Handbook: A User's Guide to Medical Herbalism. Rochester, VT: Healing Arts Press, 1988, 67.

32. Boyd EM. Expectorants and respiratory tract fluid. Pharmacol Rev 1954;6:521-42 [review].

33. Sridhar MK. Nutrition and lung health. BMJ 1995;310:75-6.

34. Hoffman D. The Herbal Handbook: A User's Guide to Medical Herbalism. Rochester, VT: Healing Arts Press, 1988, 67.

35. Boyd EM. Expectorants and respiratory tract fluid. Pharmacol Rev 1954;6:521-42 [review].

36. Hoffman D. The Herbal Handbook: A User's Guide to Medical Herbalism. Rochester, VT: Healing Arts Press, 1988, 67.

37. Boyd EM. Expectorants and respiratory tract fluid. Pharmacol Rev 1954;6:521-42 [review].

38. Gualtierotti R, Solimene U, Tonoli D. Ionized air respiratory rehabilitation technics. Minerva Med 1977;68:3383-9.

39. Jones DP, O'Connor SA, Collins JV, et al. Effect of long-term ionized air treatment on patients with bronchial asthma. Thorax 1976;31:428-32.

40. Businco L, Businco E. Allergic pathogenesis in chronic bronchitis. Allergol Immunopathol (Madr) 1975;3:1-8.

41. Krawczyk Z. Role of allergy of the immediate type in the pathogenesis of chronic bronchitis in adults. Pneumonol Pol 1976;44:829-36 [in Polish].

42. No author listed. Preliminary study on the relation between allergy and chronic bronchitis. Chin Med J 1976;2:63-8.

43. Rowe AH, Rowe A Jr, Sinclair C. Food allergy: its role in the symptoms of obstructive emphysema and chronic bronchitis. J Asthma Res 1967;5:11-20.

44. Pingleton SK, Harmon GS. Nutritional management in acute respiratory failure. JAMA 1987;257:3094-9.

45. Fiaccadori E, Del Canale S, Coffrini E, et al. Hypercapnic-hypoxemic chronic obstructive pulmonary disease (COPD): influence of severity of COPD on nutritional status. Am J Clin Nutr 1988;48:680-5.

46. Efthimiou J, Mounsey PJ, Bensen DN, et al. Effect of carbohydrate rich versus fat rich loads on gas exchange and walking performance in patients with chronic obstructive lung disease. Thorax 1992;47:451-6.

47. Miedema I, Feskens EJM, Heederik D, et al. Dietary determinants of long-term incidence of chronic nonspecific lung diseases. Am J Epidemiol 1993;138:37-45.

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The information presented by TraceGains is for informational purposes only. It is based on scientific studies (human, animal, or in vitro), clinical experience, or traditional usage as cited in each article. The results reported may not necessarily occur in all individuals. Self-treatment is not recommended for life-threatening conditions that require medical treatment under a doctor's care. For many of the conditions discussed, treatment with prescription or over the counter medication is also available. Consult your doctor, practitioner, and/or pharmacist for any health problem and before using any supplements or before making any changes in prescribed medications. Information expires December 2024.

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