Angina

Coenzyme Q10 contributes to the energy-making mechanisms of the heart. Angina patients given 150 mg of coenzyme Q10 each day have experienced greater ability to exercise without experiencing chest pain.¹ This has been confirmed in independent investigations.²

L-carnitine is an amino acid needed to transport fats into the mitochondria (the place in the cell where fats are turned into energy). Adequate energy production is essential for normal heart function. Several studies using 1 gram of L-carnitine two to three times per day showed an improvement in heart function and a reduction in symptoms of angina.^3,4,5Coenzyme Q10 also contributes to the energy-making mechanisms of the heart. Angina patients given 150 mg of coenzyme Q10 each day have experienced greater ability to exercise without experiencing chest pain.⁶ This has been confirmed in independent investigations.⁷

Nitroglycerin and similar drugs cause dilation of arteries by interacting with nitric oxide, a potent stimulus for dilation. Nitric oxide is made from arginine, a common amino acid. Blood cells in people with angina are known to make insufficient nitric oxide,⁸ which may in part be due to abnormalities of arginine metabolism. Taking 2 grams of arginine three times per day for as little as three days has improved the ability of angina sufferers to exercise.⁹ Seven of ten people with severe angina improved dramatically after taking 9 grams of arginine per day for three months in an uncontrolled study.¹⁰ Detailed studies have investigated the mechanism of arginine and have proven it operates by stimulating blood vessel dilation.¹¹

Fish oil, which contains the fatty acids known as EPA and DHA, has been studied in the treatment of angina. In some studies, enough fish oil to provide a total of about 3 grams of EPA and 2 grams of DHA has reduced chest pain as well as the need for nitroglycerin;¹² other investigators could not confirm these findings.¹³ People who take fish oil may also need to take vitamin E to protect the oil from undergoing potentially damaging oxidation in the body.¹⁴ It is not known how much vitamin E is needed to prevent such oxidation; the amount required would presumably depend on the amount of fish oil used. In one study, 300 IU of vitamin E per day prevented oxidation damage in individuals taking 6 grams of fish oil per day.¹⁵

The fruit, leaves, and flowers of the hawthorn tree contain flavonoids, including oligomeric procyanidins, which may protect blood vessels from damage. A 60 mg hawthorn extract containing 18.75% oligomeric procyanidins taken three times per day improved heart function and exercise tolerance in angina patients in a small clinical trial.¹⁶

Magnesium deficiency may be a contributing factor for spasms that occur in coronary arteries, particularly in variant angina.^17,18 While studies have used injected magnesium to stop such attacks effectively,^19,20 it is unclear whether oral magnesium would be effective in preventing or treating blood vessel spasms. One double-blind study of patients with exercise-induced angina, however, showed that oral magnesium supplementation (365 mg twice a day) for 6 months significantly reduced the incidence of exercise-induced chest pain, compared with a placebo.²¹

NAC (N-acetyl cysteine) may improve the effects of nitroglycerin in people with angina.²² People with unstable angina who took 600 mg of NAC three times daily in combination with a nitroglycerin transdermal (skin) patch for four months had significantly lower rates of subsequent heart attacks than did people who used either therapy alone or placebo.²³

In a controlled study, men with severe coronary heart disease were given an exercise test, after which they took either 15 grams of ribose or a placebo four times daily for three days. Compared with the initial test, men taking ribose were able to exercise significantly longer before experiencing chest pain and before abnormalities appeared on their electrocardiogram (ECG), but only the ECG changes were significantly improved compared with those in the placebo group.²⁴ Sports supplement manufacturers recommend 1 to 10 grams per day of ribose, while heart disease patients and people with rare enzyme deficiencies have been given up to 60 grams per day.

Low levels of antioxidant vitamins in the blood, particularly vitamin E, are associated with greater rates of angina.²⁵ This is true even when smoking and other risk factors for angina are taken into account. Early short-term studies using 300 IU (International Units) per day of vitamin E could not find a beneficial action on angina.²⁶ A later study supplementing small amounts of vitamin E (50 IU per day) for longer periods of time showed a minor benefit in people suffering angina.²⁷ Those affected by variant angina have been found to have the greatest deficiency of vitamin E compared with other angina patients.²⁸

Bromelain has been reported in a preliminary study to relieve angina. In that study, 600 people with cancer were receiving bromelain (400 to 1,000 mg per day). Fourteen of those individuals had been suffering from angina. In all 14 cases, the angina disappeared within 4 to 90 days after starting bromelain.²⁹ However, as there was no control group in the study, the possibility of a placebo effect cannot be ruled out. Bromelain is known to prevent excessive stickiness of blood platelets,³⁰ which is believed to be one of the triggering factors for angina.

Khella is an African plant that contains spasm-relieving compounds, including khellin. Purified khellin was shown to be helpful in relieving angina in preliminary studies in the 1940s and 1950s.^31,32 It is unknown whether the whole herb would have the same effects. Due to the potential side effects of khella, people with angina should consult with a physician knowledgeable in botanical medicine before taking it.

Kudzu is used in modern Chinese medicine as a treatment for angina. Standardized root tablets (10 mg tablet is equivalent to 1.5 grams of the crude root) are sometimes used for angina pectoris in the amount of 30 to 120 mg per day.