DOCEFREZ

Docetaxel 80mg, Lyophilisate for solution for injection

Grapefruit juice

· Severity: Major

· Notes for Consumers: Do not drink Grapefruit Juice while taking Docetaxel. Side effects from Docetaxel may get worse. If you notice new or worsening side effects such as fever or chills, sore throat, bruising, pinpoint red spots on the skin, unusual weakness or tiredness, diarrhea, difficulty breathing, nausea, vomiting, stomach pain and/or cramping, or if you notice new or worsening tingling in fingers and/or toes, or inability to pick-up items with your fingers, contact your health care provider immediately.

· Notes for Professionals: Advise patients to avoid grapefruit juice while on docetaxel due to increased plasma concentrations of docetaxel. Docetaxel is a CYP3A4 substrate and grapefruit juice is a strong CYP3A4 inhibitor. Concomitant use with another strong CYP3A4 inhibitor increased docetaxel exposure by 2.2-fold.

<b>DISCLAIMER:</b><em> This drug information content is provided for informational purposes only and is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Patients should always consult their physician with any questions regarding a medical condition and to obtain medical advice and treatment. Drug information is sourced from GSDD (Gold Standard Drug Database ) provided by Elsevier.</em>