CLARITHROMYCIN

Clarithromycin 500mg, Oral tablet

Cannabis

· Severity: Major

· Notes for Consumers: Discuss cannabis use with your care team. The effects of cannabis may be altered if used with your medication. Call emergency services right away if you experience slow or shallow breathing, shortness of breath, feeling faint, dizziness, confusion, or trouble staying awake.

· Notes for Professionals: Advise patients to avoid cannabis use during clarithromycin treatment. Concomitant use may alter the exposure of some cannabinoids and increase the risk for adverse reactions. The cannabinoids delta-9-tetrahydrocannabinol (THC) and cannabidiol (CBD) are CYP3A substrates and clarithromycin is a strong CYP3A inhibitor. Concomitant use of a cannabinoid product containing THC and CBD at an approximate 1:1 ratio with another strong CYP3A inhibitor increased THC, 11-OH-THC, and CBD peak exposures by 1.3-, 3-, and 1.9-fold respectively.

Clarithromycin 500mg, Oral tablet

Grapefruit juice

· Severity: Mild

· Notes for Consumers: Grapefruit juice and grapefruit-containing foods may increase the side effects of Clarithromycin. There may be no interaction. Do not significantly change your grapefruit intake while taking Clarithromycin.

· Notes for Professionals: Grapefruit juice has been reported to decrease the metabolism of drugs metabolized via cytochrome CYP 3A4 isozyme. Grapefruit juice contains compounds that inhibit CYP3A4 in enterocytes in the GI tract. In a randomized crossover study in healthy volunteers, grapefruit juice did not have a significant affect on the bioavailability of clarithromycin nor did it affect the metabolism of clarithromycin to its active metabolite.

<b>DISCLAIMER:</b><em> This drug information content is provided for informational purposes only and is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Patients should always consult their physician with any questions regarding a medical condition and to obtain medical advice and treatment. Drug information is sourced from GSDD (Gold Standard Drug Database ) provided by Elsevier.</em>