ALEVE PM
  • ALEVE PM

  • QTY 20 • 220MG-25MG • Tablet • Near 77381

DIPHENHYDRAMINE; NAPROXEN (dye fen HYE dra meen; na PROX en) is a combination of an antihistamine sleep aid and a non-steroidal anti-inflammatory drug (NSAID). It is used to treat occasional sleeplessness with minor aches and pains.

ALEVE PM Lifestyle Interactions

Naproxen Sodium 220mg, Diphenhydramine Hydrochloride 25mg, Oral tablet

Alcohol

· Severity: Major

· Notes for Consumers: Side effects from this drug may get worse if you drink alcohol-containing drinks. If you have persistent stomach upset, vomit blood or what looks like coffee grounds, or have black, tarry stools, contact your health care provider immediately. It is best to limit or avoid alcohol containing drinks while taking this drug, even with short term use. Many non-prescription products for headaches, pain, arthritis, or sinus pain contain drugs that may cause stomach problems along with alcohol; closely read labels before taking any medicines with alcohol-containing drinks.

· Notes for Professionals: Concomitant ingestion of ethanol with NSAIDs increases the risk of developing gastric irritation and GI mucosal bleeding. Ethanol is a mucosal irritant and NSAIDs decrease platelet aggregation. Routine ingestion of ethanol and NSAIDs can cause significant GI bleeding, which may or may not be overt. Even occasional concomitant use of NSAIDs and ethanol should be avoided. Chronic alcoholism is often associated with hypoprothrombinemia and this condition increases the risk of bleeding. Systemic exposure of NSAIDs that are primary substrates for CYP2C9, such as diclofenac, may be increased during use of ethanol, which is a dose-dependent inhibitor of CYP2C9. The effects of ethanol may also be substrate-dependent, since in vitro data have shown varying inhibitory effects on 2C9 substrates.The manufacturer of diclofenac; misoprostol recommends that the total daily dose of diclofenac not exceed 100 mg in patients receiving a CYP2C9 inhibitor. Patients should be warned regarding the potential for increased risk of GI bleeding if alcohol-containing beverages are taken concurrently with NSAIDs.

Naproxen Sodium 220mg, Diphenhydramine Hydrochloride 25mg, Oral tablet

Marijuana

· Severity: Moderate

· Notes for Consumers: Although an interaction is possible, these drugs may be used together. In therory, the actions of Marijuana, Medical may be decreased if you take Nonsteroidal Antiinflammatory Drugs (NSAIDs). However, the importance of this interaction is not known. Patients receiving this drug combination may notice decreased euphoria and heart rate.

· Notes for Professionals: Administering nonsteroidal antiinflammatory drugs (NSAIDs) concurrently with marijuana may limit some of marijuana's pharmacologic activities. Certain actions of marijuana require prostaglandin-mediated processes to occur; NSAIDs may interfere with these processes thereby decreasing marijuana's effect. Coadministration of indomethacin with marijuana has been shown to significantly decrease euphoria, tachycardia, and the intraocular pressure lowering activity of marijuana.

Naproxen Sodium 220mg, Diphenhydramine Hydrochloride 25mg, Oral tablet

Tobacco

· Severity: Moderate

· Notes for Consumers: Tobacco-smoking may increase the risk for ulcers and gastrointestinal problems with these drugs. Ask your health care provider about a plan to stop smoking. If you have persistent stomach upset, vomit blood or what looks like coffee grounds, or have black, tarry stools, contact your health care provider immediately.

· Notes for Professionals: Concomitant use of nonsteroidal antiinflammatory drugs (NSAIDs) with tobacco smoking may enhance the risk of gastrointestinal (GI) side effects. Tobacco smoking may independently increase the risk of peptic ulcer and GI bleeding, and thus may increase the risk with NSAID usage. Patients using tobacco and NSAIDs concurrently should be monitored closely for GI adverse reactions.

Naproxen Sodium 220mg, Diphenhydramine Hydrochloride 25mg, Oral tablet

Alcohol

· Severity: Moderate

· Notes for Consumers: It is best to limit or avoid alcoholic drinks while you are taking this medicine. Using this medicine with alcohol can lead to additive side effects such as increased drowsiness. Do not drive or operate machinery if you are drinking alcohol-containing beverages. If you notice slurred speech, confusion, severe weakness, or difficulty breathing, contact your health care provider immediately.

· Notes for Professionals: Drowsiness may occur with the use of sedating antihistamines. Caution patients about the simultaneous use of alcohol, and caution that the effects of alcohol may be increased. Additive drowsiness and psychomotor impairment may occur.

NOTE: This sheet is a summary. It may not cover all possible information. If you have questions about this medicine, talk to your doctor, pharmacist, or health care provider.

DISCLAIMER: This content is provided for informational purposes only. The content is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Patients should always consult their physician with any questions regarding a medical condition and to obtain medical advice and treatment.

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