VYVANSE (Brand for LISDEXAMFETAMINE DIMESYLATE)

Lisdexamfetamine Dimesylate 40mg, Oral capsule

Acidic food

· Severity: Moderate

· Notes for Consumers: Most foods are not expected to cause a problem with this medication, so do not significantly alter your diet unless directed to do so by your health care professional. Acidic juices, like citrus juices (examples: orange juice, grapefruit juice) may decrease the absorption of this medication and are best avoided during the 1 hour before a dose, at the time of dosing, and for 1 hour after taking a dose. You may need to limit caffeine intake (food examples: coffee, teas, colas, and chocolate) while taking this medicine. Taking a high amount of caffeine can increase the risk of irritability, nausea, nervousness, palpitations, problems with sleep (insomnia), rapid heartbeat, or other side effects.

· Notes for Professionals: In general, food does not significantly interact with the amphetamine stimulants, a dose may be taken with or without food. However, certain gastrointestinal acidifying agents (e.g., certain fruit juices, etc.) can lower the oral absorption of amphetamines. To ensure proper absorption, it may be prudent for the patient to avoid citrus fruits and citrus juices 1 hour before a dose, at the time of dosing, and for the 1 hour following a dose. In addition, the excretion of amphetamines is increased in acidic urine and decreased in alkaline urine. Foods that acidify the urine, such as cranberry juice, orange juice, or those that contain vitamin C (ascorbic acid) may increase amphetamine renal excretion. Conversely, foods that alkalinize the urine, such as beets, dairy products, kale, spinach may slightly slow urinary excretion of amphetamines. Patients should not significantly alter their diets, however, as these changes in urinary pH from foods are not expected to be clinically significant for most patients.

Lisdexamfetamine Dimesylate 40mg, Oral capsule

Caffeine-containing Foods/Beverages

· Severity: Moderate

· Notes for Consumers: Limit caffeine intake (examples: coffee, teas, colas, chocolate and some herbal supplements) while taking this medicine. Also avoid medicines containing additional caffeine whenever possible. Side effects may get worse if you take excessive caffeine. Taking a high amount of caffeine can increase the risk of nausea, nervousness, palpitations, problems with sleep, rapid heartbeat, tremor, or other side effects.

· Notes for Professionals: CNS-stimulating actions of caffeine can be additive with other CNS stimulants. Patients may need to reduce, limit, or avoid caffeine intake. Excessive caffeine ingestion (via medicines, supplements or beverages including coffee, green tea, other teas, guarana, colas) may contribute to side effects like nervousness, irritability, insomnia, or tremor.

Lisdexamfetamine Dimesylate 40mg, Oral capsule

Foods that acidify the urine

· Severity: Moderate

· Notes for Consumers: Most foods are not expected to cause a problem with Lisdexamfetamine, so do not significantly alter your diet unless directed to do so by your health care professional. You may need to limit caffeine intake (food examples: coffee, teas, colas, and chocolate) while taking this medicine. Taking a high amount of Caffeine can increase the risk of irritability, nausea, nervousness, palpitations, problems with sleep (insomnia), rapid heartbeat, or other side effects.

· Notes for Professionals: Foods that acidify the urine, such as cranberry juice, orange juice, or those that contain ascorbic acid, vitamin C may increase amphetamine renal excretion. Patients should not significantly alter their diets, however as these changes are not expected to be clinically significant.

Lisdexamfetamine Dimesylate 40mg, Oral capsule

Foods that alkalinize urine

· Severity: Moderate

· Notes for Consumers: Most foods are not expected to cause a problem with Lisdexamfetamine, so do not significantly alter your diet unless directed to do so by your health care professional. You may need to limit caffeine intake (food examples: coffee, teas, colas, and chocolate) while taking this medicine. Taking a high amount of Caffeine can increase the risk of irritability, nausea, nervousness, palpitations, problems with sleep (insomnia), rapid heartbeat, or other side effects.

· Notes for Professionals: Foods that alkalinize the urine, such as beets, dairy products, kale, spinach may slightly slow urinary excretion of amphetamines. Patients should not significantly alter their diets, however as these changes are not expected to be clinically significant.

<b>DISCLAIMER:</b><em> This drug information content is provided for informational purposes only and is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Patients should always consult their physician with any questions regarding a medical condition and to obtain medical advice and treatment. Drug information is sourced from GSDD (Gold Standard Drug Database ) provided by Elsevier.</em>