TOVIAZ (Brand for FESOTERODINE FUMARATE ER)

Fesoterodine fumarate 4mg, Oral tablet, extended release

Grapefruit juice

· Severity: Major

· Notes for Consumers: Do not take Fesoterodine and Grapefruit juice together without talking to your health care provider. Side effects from Fesoterodine may get worse if you take Grapefruit juice or grapefruit-containing foods. Discuss any new or worsening side effects, such as constipation, dizziness, difficulty with urination, dry mouth and eyes, changes in vision, fast heartbeat, or confusion, with your health care provider.

· Notes for Professionals: Advise patients to avoid grapefruit juice while taking fesoterodine due to increased fesoterodine exposure. Fesoterodine is a CYP3A4 substrate and grapefruit juice is a strong CYP3A4 inhibitor. Coadministration with another strong CYP3A4 inhibitor led to approximately a doubling of the AUC of 5-hydroxymethyl tolterodine (5-HMT), the active metabolite of fesoterodine.

<b>DISCLAIMER:</b><em> This drug information content is provided for informational purposes only and is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Patients should always consult their physician with any questions regarding a medical condition and to obtain medical advice and treatment. Drug information is sourced from GSDD (Gold Standard Drug Database ) provided by Elsevier.</em>