NISOLDIPINE (Generic for SULAR)

Nisoldipine 8.5mg, Oral tablet, extended release

Grapefruit juice

· Severity: Major

· Notes for Consumers: Avoid taking Nisolodipine with grapefruit juice. Grapefruit juice and grapefruit-containing foods may significantly increase the effects of Nisoldipine. If the blood pressure drops too low while taking this medicine, you may become dizzy or feel faint; do not stand or sit up too quickly. Contact your prescriber if you have dizziness which does not go away while taking this medicine. If you notice new or increased swelling of your legs or ankles, tell your health care provider.

· Notes for Professionals: Grapefruit juice contains compounds that inhibit cytochrome P-450 CYP3A4 isozymes in the gut wall. Grapefruit juice can increase the serum concentrations and oral bioavailability of nisoldipine. Concomitant ingestion of grapefruit juice with nisoldipine should be avoided since coadministration may result in an increase in Cmax and AUC.

<b>DISCLAIMER:</b><em> This drug information content is provided for informational purposes only and is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Patients should always consult their physician with any questions regarding a medical condition and to obtain medical advice and treatment. Drug information is sourced from GSDD (Gold Standard Drug Database ) provided by Elsevier.</em>