LOPINAVIR-RITONAVIR
  • LOPINAVIR-RITONAVIR (Generic for KALETRA)

  • QTY 10 • 100MG-25MG • Tablet • Near 77381

LOPINAVIR; RITONAVIR (loe PIN a veer; ri TOE na veer) is 2 antiretroviral medicines in 1 tablet. It is used with other medicines to treat HIV. This medicine is not a cure for HIV. This medicine can lower, but not fully prevent, the risk of spreading HIV to others.

LOPINAVIR-RITONAVIR (Generic for KALETRA) Lifestyle Interactions

Lopinavir 100mg, Ritonavir 25mg, Oral tablet

Marijuana

· Severity: Major

· Notes for Consumers: Discuss marijuana use with your care team. The effects of marijuana may be altered if used with your medication. Call emergency services right away if you experience slow or shallow breathing, difficulty staying awake, or are unable to respond or wake up.

· Notes for Professionals: Advise patients to avoid marijuana use during protease inhibitor treatment. Concomitant use may alter the exposure of some cannabinoids and increase the risk for adverse reactions. The cannabinoids delta-9-tetrahydrocannabinol (THC) and cannabidiol (CBD) are CYP3A substrates and protease inhibitors are strong CYP3A inhibitors. Concomitant use of a cannabinoid product containing THC and CBD at an approximate 1:1 ratio with another strong CYP3A inhibitor increased THC, 11-OH-THC, and CBD peak exposures by 1.3-, 3-, and 1.9-fold respectively.

Lopinavir 100mg, Ritonavir 25mg, Oral tablet

Grapefruit juice

· Severity: Moderate

· Notes for Consumers: Although an interaction is possible, these drugs may be given with grapefruit juice. If given with grapefruit juice, you may experience more side effects. If you notice any new or unusual side effects, notify your health care provider immediately. You will be closely monitored.

· Notes for Professionals: Concurrent administration of ritonavir with grapefruit juice may result in elevated ritonavir concentrations. Grapefruit juice is an inhibitor of the hepatic isoenzymes CYP3A4 and CYP2D6, and an inhibitor of the drug transporter P-glycoprotein (P-gp). Ritonavir is metabolized by both enzymes and is a substrate for P-gp. Caution and close monitoring are advised if these drugs are administered together.

Lopinavir 100mg, Ritonavir 25mg, Oral tablet

Marijuana

· Severity: Major

· Notes for Consumers: Discuss marijuana use with your care team. The effects of marijuana may be altered if used with your medication. Call emergency services right away if you experience slow or shallow breathing, difficulty staying awake, or are unable to respond or wake up.

· Notes for Professionals: Advise patients to avoid marijuana use during protease inhibitor treatment. Concomitant use may alter the exposure of some cannabinoids and increase the risk for adverse reactions. The cannabinoids delta-9-tetrahydrocannabinol (THC) and cannabidiol (CBD) are CYP3A substrates and protease inhibitors are strong CYP3A inhibitors. Concomitant use of a cannabinoid product containing THC and CBD at an approximate 1:1 ratio with another strong CYP3A inhibitor increased THC, 11-OH-THC, and CBD peak exposures by 1.3-, 3-, and 1.9-fold respectively.

<b>DISCLAIMER:</b><em> This drug information content is provided for informational purposes only and is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Patients should always consult their physician with any questions regarding a medical condition and to obtain medical advice and treatment. Drug information is sourced from GSDD (Gold Standard Drug Database ) provided by Elsevier.</em>

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