ISONIAZID

Isoniazid 300mg, Oral tablet

Alcohol

· Severity: Major

· Notes for Consumers: Do not drink alcohol while taking this medication. Drinking alcohol while taking this medication increases the risk of liver injury. Contact your care team right away if you experience right upper belly pain, loss of appetite, nausea, light-colored stool, dark yellow or brown urine, yellowing skin or eyes, or unusual weakness or fatigue.

· Notes for Professionals: Advise patients to avoid alcohol consumption while taking isoniazid. Daily consumption of alcohol increases the risk of isoniazid-induced hepatitis and can increase the clearance of isoniazid.

Isoniazid 300mg, Oral tablet

Caffeine-containing Foods/Beverages

· Severity: Moderate

· Notes for Consumers: Try to limit caffeine intake while taking Isoniazid, INH. Side effects from Isoniazid, INH may get worse if you take Caffeine, like increased blood pressure, confusion, restlessness, or other side effects. All preparations containing caffeine should be used sparingly such as tea, coffee, chocolate, cola, or 'stay awake' products. Some nonprescription medicines also contain caffeine and should not be taken along with Isoniazid, INH.

· Notes for Professionals: Although isoniazid does not inhibit mitochondrial MAO, it does appear to inhibit plasma MAO. Dangerous cardiac arrhythmias or severe hypertension can occur because of the potentiation of caffeine's sympathomimetic effects by MAOIs. Caffeine use should be minimized or avoided during and for 1 to 2 weeks after discontinuation of any MAOI.

Isoniazid 300mg, Oral tablet

Tyramine-containing foods

· Severity: Moderate

· Notes for Consumers: Food interactions with Isoniazid, INH may cause increased blood pressure or other effects. Try to limit the following foods in the diet: aged cheeses; soy sauce; fava bean or broad bean pods; smoked or pickled meats, poultry; or fish (lox, herring, smoked salmon); fermented sausages (bologna, pepperoni, salami, summer sausage); bananas; avocados; and any over-ripe fruit. Dietary restrictions should continue for at least 2 weeks after stopping Isoniazid, INH.

· Notes for Professionals: Isoniazid may possess enough MAO inhibiting activity to produce clinical symptoms when combined with the ingestion of histamine and tyramine-containing foods. Reactions reported include headache, palpitations, flushing, nausea/vomiting, and pruritus; increased blood pressure may occur if the food contains high tyramine content.

<b>DISCLAIMER:</b><em> This drug information content is provided for informational purposes only and is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Patients should always consult their physician with any questions regarding a medical condition and to obtain medical advice and treatment. Drug information is sourced from GSDD (Gold Standard Drug Database ) provided by Elsevier.</em>