DOXYCYCLINE HYCLATE
  • DOXYCYCLINE HYCLATE (Generic for ACTICLATE)

  • QTY 14 • 100 MG • Capsule • Near 77381

DOXYCYCLINE (dox i SYE kleen) treats infections caused by bacteria. It belongs to a group of medications called tetracycline antibiotics. It will not treat colds, the flu, or infections caused by viruses.

DOXYCYCLINE HYCLATE (Generic for ACTICLATE) Lifestyle Interactions

Doxycycline Hyclate 100mg, Oral capsule

Calcium-containing foods

· Severity: Moderate

· Notes for Consumers: Take Doxycyline with plenty of fluid to reduce the risk of irritation to the stomach or esophagus (tube leading from mouth to stomach). For best results give Doxycycline at least 1 hour prior to or 2 hours after a meal and/or milk. Doxycycline may be taken with foods or milk if stomach irritation occurs.

· Notes for Professionals: Divalent or trivalent cations readily chelate with tetracycline antibiotics, forming insoluble compounds. The oral absorption of certain tetracycline class antibiotics will be reduced by agents containing these cations (e.g., calcium) and it is often recommended to avoid administration within 1 to 2 hours of interfering foods (e.g., dairy products). However, the oral absorption of doxycycline appears to be less affected by food interactions than tetracycline. Some manufacturers state that absorption of oral doxycycline is not markedly influenced by simultaneous ingestion of food or milk and recommend taking doxycycline with food or milk if gastric irritation occurs upon administration. However, there are studies describing altered doxycycline pharmacokinetics when given with meals containing dairy products. A single-dose study of Periostat given with a 1,000 calorie, high-fat, high-protein meal, which included dairy products, resulted in a decrease in the rate and extent of absorption and delay in the time to maximum concentrations. The dual-release capsules (Oracea) are not bioequivalent to other doxycycline products; absorption may be decreased when given with meals. In a single-dose food effect study, the Cmax and AUC of doxycycline (as Oracea) were reduced by about 45% and 22%, respectively, in healthy volunteers fed a 1,000 calorie, high-fat, high-protein meal which included dairy products. The reductions in AUC and Cmax can be clinically significant.

Doxycycline Hyclate 100mg, Oral capsule

Foods High in Iron

· Severity: Moderate

· Notes for Consumers: Take Doxycyline with plenty of fluid to reduce the risk of irritation to the stomach or esophagus (tube leading from mouth to stomach). For best results give Doxycycline at least 1 hour prior to or 2 hours after a meal and/or milk. Doxycycline may be taken with foods or milk if stomach irritation occurs.

· Notes for Professionals: Divalent or trivalent cations readily chelate with tetracycline antibiotics, forming insoluble compounds. The oral absorption of certain tetracycline class antibiotics will be reduced by agents containing these cations (e.g., iron) and it is often recommended to avoid administration within at least 1 to 2 hours of interfering foods (e.g., foods containing high amounts of iron). However, the oral absorption of doxycycline appears to be less affected by food interactions than tetracycline. Some manufacturers state that absorption of oral doxycycline is not markedly influenced by simultaneous ingestion of food or milk and recommend taking doxycycline with food or milk if gastric irritation occurs upon administration. However, there are studies describing altered doxycycline pharmacokinetics when given with meals. A single-dose study of Periostat given with a 1,000 calorie, high-fat, high-protein meal, which included dairy products, resulted in a decrease in the rate and extent of absorption and delay in the time to maximum concentrations. The dual-release capsules (Oracea) are not bioequivalent to other doxycycline products; absorption may be decreased when given with meals. In a single-dose food effect study, the Cmax and AUC of doxycycline (as Oracea) were reduced by about 45% and 22%, respectively, in healthy volunteers fed a 1,000 calorie, high-fat, high-protein meal which included dairy products. The reductions in AUC and Cmax can be clinically significant.

<b>DISCLAIMER:</b><em> This drug information content is provided for informational purposes only and is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Patients should always consult their physician with any questions regarding a medical condition and to obtain medical advice and treatment. Drug information is sourced from GSDD (Gold Standard Drug Database ) provided by Elsevier.</em>

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