APREPITANT
  • APREPITANT (Generic for EMEND)

  • QTY 1 • 40 MG • Capsule • Near 77381

APREPITANT/Emend (ap RE pi tant) prevents nausea and vomiting from chemotherapy. It works by blocking substances in your body that may cause nausea and vomiting. It belongs to a class of medications called antiemetics.

APREPITANT (Generic for EMEND) Lifestyle Interactions

Aprepitant 40mg, Oral capsule

Grapefruit juice

· Severity: Major

· Notes for Consumers: Do not take Aprepitant, Fosaprepitant with grapefruit juice. Increased side effects may be observed if these drugs are given together. Discuss possible alternative options with your health care provider.

· Notes for Professionals: Avoid the concomitant use of aprepitant, fosaprepitant with grapefruit juice due to substantially increased exposure of aprepitant. After administration, fosaprepitant is rapidly converted to aprepitant. Grapefruit juice is a strong CYP3A4 inhibitor and aprepitant is a CYP3A4 substrate. Coadministration of a single oral dose of aprepitant on day 5 of a 10-day ketoconazole regimen (strong CYP3A4 inhibitor) increased the aprepitant AUC approximately 5-fold, and increased the mean terminal half-life by approximately 3-fold.

<b>DISCLAIMER:</b><em> This drug information content is provided for informational purposes only and is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Patients should always consult their physician with any questions regarding a medical condition and to obtain medical advice and treatment. Drug information is sourced from GSDD (Gold Standard Drug Database ) provided by Elsevier.</em>

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