APOKYN (Brand for APOMORPHINE HCL)

Apomorphine Hydrochloride 10mg/1mL, Solution for injection

Alcohol

· Severity: Major

· Notes for Consumers: Do not drink alcohol while taking this medication. Drinking alcohol while taking this medication can cause serious side effects, such as central nervous system (CNS) depression and dangerously low blood pressure, and can increase the risk of falling. Call emergency services right away if you experience symptoms of CNS depression: slow or shallow breathing, shortness of breath, feeling faint, dizziness, confusion, trouble staying awake. Contact your care team right away if you experience symptoms of dangerously low blood pressure: dizziness, feeling faint or lightheaded, blurry vision.

· Notes for Professionals: Advise patients to avoid alcohol-containing beverages during apomorphine therapy. Concurrent use of alcohol and apomorphine has resulted in significantly worse orthostatic hypotension compared to apomorphine alone. Coadministration of low dose ethanol (0.3 grams/kg) with subcutaneous apomorphine in healthy subjects did not have a significant effect on the pharmacokinetics of apomorphine; however, high dose alcohol (0.6 grams/kg), equivalent to about 3 standardized alcohol-containing beverages, increased the maximum concentration of apomorphine by about 63%. A similar study with sublingual apomorphine has not been conducted.

Apomorphine Hydrochloride 10mg/1mL, Solution for injection

Cannabis

· Severity: Major

· Notes for Consumers: Discuss cannabis use with your care team. The effects of your medication may be altered if used with cannabis. Call emergency services right away if you experience slow or shallow breathing, shortness of breath, feeling faint, dizziness, confusion, or trouble staying awake.

· Notes for Professionals: Advise patients to avoid cannabis use while taking CNS depressants due to the risk for additive CNS depression and potential for other cognitive adverse reactions.

<b>DISCLAIMER:</b><em> This drug information content is provided for informational purposes only and is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Patients should always consult their physician with any questions regarding a medical condition and to obtain medical advice and treatment. Drug information is sourced from GSDD (Gold Standard Drug Database ) provided by Elsevier.</em>