1. Cassidy JD, Carroll LJ, Cote P. The Saskatchewan health and back pain survey. The prevalence of low back pain and related disability in Saskatchewan adults. Spine 1998;23:1860-6.
2. Cohen KB. Pregnancy and low back pain. California Chiropractic Journal 1989;November:43-7.
3. Kelsey JL, Githens PB, O'Conner T, et al. Acute prolapsed lumbar intervertebral disc. An epidemiologic study with special reference to driving automobiles and cigarette smoking. Spine 1984;9:608-13.
4. Frymoyer JW. Lumbar disk disease: epidemiology. Instr Course Lect 1992;41:217-23 [review].
5. Andersson GBJ. Diagnostic considerations in patients with back pain. Phys Med Rehabil Clin N Am 1998;9:309-22.
6. Smedley J, Inskip H, Cooper C, et al. Natural history of low back pain. A longitudinal study in nurses. Spine 1998;23:2422-6.
7. Skargren EI, Carlsson PG, Oberg BE. One-year follow-up comparison of the cost and effectiveness of chiropractic and physiotherapy as primary management for back pain. Subgroup analysis, recurrence, and additional health care utilization. Spine 1998;23:1875-83.
8. MacDonald MJ, Sorock GS, Volinn E, et al. A descriptive study of recurrent low back pain claims. J Occup Environ Med 1997;39:35-43.
9. Thomas E, Silman AJ, Croft PR, et al. Predicting who develops chronic low back pain in primary care: a prospective study. BMJ 1999;318:1662-7.
10. Hingorani K. Oral enzyme therapy in severe back pain. Br J Clin Pract 1968;22:209-10.
11. Gaspardy G, Balint G, Mitsuova M, et al. Treatment of sciatica due to intervertebral disc herniation with Chymoral tablets. Rheum Phys Med 1971;11:14-9.
12. Gibson T, Dilke TFW, Grahame R. Chymoral in the treatment of lumbar disc prolapse. Rheumatol Rehabil 1975;14:186-90.
13. Ehrenpreis S. Analgesic properties of enkephalinase inhibitors: animal and human studies. Prog Clin Biol Res 1985;192:363-70.
14. Balagot RC, Ehrenpreis S, Kubota K, Greenberg J. Analgesia in mice and humans by D-phenylalanine: Relation to inhibition of enkephalin degradation and enkephalin levels. In: Bonica JJ, Liebeskind JC, Albe-Fessard DG, eds., Advances in Pain Research and Therapy, Vol 5. New York: Raven Press, 1983, 289-93.
15. Gaby AR. Editor's Corner. Northwest Acad Prev Med 1983;July:3, 5, 8.
16. Walsh NE, Ramamurthy S, Schoenfeld LS, Hoffman J. Analgesic effectiveness of D-phenylalanine in chronic pain patients. Arch Phys Med Rehabil 1986;67:436-9.
17. Kitade T, Odahara Y, Shinohara S, et al. Studies on the enhanced effect of acupuncture analgesia and acupuncture anesthesia bu D-phenylalanine (2nd report)—schedule of administration and clinical effects in low back pain and tooth extraction. Acupunct Electrother Res 1990;15:121-35.
18. Schwieger G, Karl H, Schonhaber E. Relapse prevention of painful vertebral syndromes in follow-up treatment with a combination of vitamins B1, B6, and B12. Ann NY Acad Sci 1990;585:54-62.
19. Kuhlwein A, Meyer HJ, Koehler CO. Reduced diclofenac administration by B vitamins: results of a randomized double-blind study with reduced daily doses of diclofenac (75 mg diclofenac versus 75 mg diclofenac plus B vitamins) in acute lumbar vertebral syndromes. Klin Wochenschr 1990;68:107-15 [in German].
20. Bruggemann G, Koehler CO, Koch EM. Results of a double-blind study of diclofenac + vitamin B1, B6, B12 versus diclofenac in patients with acute pain of the lumbar vertebrae. A multicenter study. Klin Wochenschr 1990;68:116-20 [in German].
21. Vetter G, Bruggemann G, Lettko M, et al. Shortening diclofenac therapy by B vitamins. Results of a randomized double-blind study, diclofenac 50 mg versus diclofenac 50 mg plus B vitamins, in painful spinal diseases with degenerative changes. Z Rheumatol 1988;47:351-62 [in German].
22. Al Faraj S, Al Mutairi K. Vitamin D deficiency and chronic low back pain in Saudi Arabia. Spine 2003;28:177-9.
23. Lotfi A, Abdel-Nasser AM, Hamdy A, et al. Hypovitaminosis D in female patients with chronic low back pain. Clin Rheumatol 2007;26:1895-901.
24. De Torrente de la Jara G, Pecoud A, Favrat B. Musculoskeletal pain in female asylum seekers and hypovitaminosis D3. BMJ 2004;329:156-7.
25. Chrubasik S, Eisenberg E, Balan E, et al. Treatment of low back pain exacerbations with willow bark extract: A randomized double-blind study. Am J Med 2000;109:9-14.
26. Seligman B. Bromelain: an anti-inflammatory agent. Angiology 1962;13:508-10.
27. Castell JV, Friedrich G, Kuhn CS, et al. Intestinal absorption of undegraded proteins in men: presence of bromelain in plasma after oral intake. Am J Physiol 1997;273:G139-46.
28. Miller JM. Absorption of orally introduced proteolytic enzymes. Clin Med 1968;75:35-42 [review].
29. Masson M. Bromelain in the treatment of blunt injuries to the musculoskeletal system. A case observation study by an orthopedic surgeon in private practice. Fortschr Med 1995;113:303-6.
30. Miller JN, Ginsberg M, McElfatrick GC, et al. The administration of bromelain orally in the treatment of inflammation and edema. Exp Med Surg 1964;22:293-9.
31. Cirelli MG. Five years experience with bromelains in therapy of edema and inflammation in postoperative tissue reaction, skin infections and trauma. Clin Med 1967;74(6):55-9.
32. Vallis C, Lund M. Effect of treatment with Carica papaya on resolution of edema and ecchymosis following rhinoplasty. Curr Ther Res 1969;11:356-9.
33. Trickett P. Proteolytic enzymes in treatment of athletic injuries. Appl Ther 1964;6:647-52.
34. Sweeny FJ. Treatment of athletic injuries with an oral proteolytic enzyme. Med Times 1963:91:765.
35. Fusco BM, Giacovazzo M. Peppers and pain. The promise of capsaicin. Drugs 1997;53:909–14 [review].
36. Schnitzer TJ. Non-NSAID pharmacologic treatment options for the management of chronic pain. Am J Med 1998;105:45S-52S [review].
37. Siften DW (ed). Physicians' Desk Reference for Nonprescription Drugs. Montvale, NJ: Medical Economics, 1998, 790-1.
38. Rumsfield JA, West DP. Topical capsaicin in dermatologic and peripheral pain disorders. DICP 1991;25:381-7 [review].
39. Chrubasik S, Zimpfer C, Schutt U, Ziegler R. Effectiveness of Harpagophytum procumbens in treatment of acute low back pain. Phytomed 1996;3:1-10.
40. Chrubasik S, Junck H, Breitschwerdt H, et al. Effectiveness of Harpagophytum extract WS 1531 in the treatment of exacerbation of low back pain: a randomized, placebo-controlled, double-blind study. Eur J Anesthesiology 1999;16:118-29.
41. Hong CZ, Shellock FG. Effects of a topically applied counterirritant (Eucalyptamint) on cutaneous blood flow and on skin and muscle temperatures. A placebo-controlled study. Am J Phys Med Rehabil 1991;70:29-33.
42. Cirelli MG. Five years experience with bromelains in therapy of edema and inflammation in postoperative tissue reaction, skin infections and trauma. Clin Med 1967;74(6):55-9.
43. Trickett P. Proteolytic enzymes in treatment of athletic injuries. Appl Ther 1964;6:647-52.
44. Sweeny FJ. Treatment of athletic injuries with an oral proteolytic enzyme. Med Times 1963:91:765.
45. Boyne PS, Medhurst H. Oral anti-inflammatory enzyme therapy in injuries in professional footballers. Practitioner 1967;198:543-6.
46. Deitrick RE. Oral proteolytic enzymes in the treatment of athletic injuries: A double-blind study. Pennsylvania Med J 1965;Oct:35-7.
47. Rathgeber WF. The use of proteolytic enzymes (Chymoral) in sporting injuries. S Afr Med J 1971;45:181-3.
48. Buck JE, Phillips N. Trial of Chymoral in professional footballers. Br J Clin Pract 1970;24:375-7.
49. Tsomides J, Goldberg RI. Controlled evaluation of oral chymotrypsin-trypsin treatment of injuries to the head and face. Clin Med 1969;76(11):40.
50. Holt HT. Carica papaya as ancillary therapy for athletic injuries. Curr Ther Res 1969;11:621-4.
51. Blonstein JL. Oral enzyme tablets in the treatment of boxing injuries. Practitioner 1967;198:547.
52. Baumüller M. Therapy of ankle joint distortions with hydrolytic enzymes—results from a double blind clinical trial. In Hermans GPH, Mosterd WL, eds. Sports, Medicine and Health. Amsterdam: Excerpta Medica, 1990, 1137.
53. Craig RP. The quantitative evaluation of the use of oral proteolytic enzymes in the treatment of sprained ankles. Injury 1975;6:313-6.
54. Hong CZ, Shellock FG. Effects of a topically applied counterirritant (Eucalyptamint) on cutaneous blood flow and on skin and muscle temperatures. A placebo-controlled study. Am J Phys Med Rehabil 1991;70:29-33.
55. Satoskar RR, Shah SJ, Shenoy SG. Evaluation of antiinflammatory property of curcumin (diferuloyl methane) in patients with postoperative inflammation. Int J Clin Pharmacol Ther Toxicol 1986;24:651-4.
56. Ghatak N, Basu N. Sodium curcuminate as an effective anti-inflammatory agent. Indian J Exp Biol 1972;10:235-6.
57. Chandra D, Gupta SS. Anti-inflammatory and anti-arthritic activity of volatile oil of curcuma longa (Haldi). Indian J Med Res 1972;60:138-42.
58. Kulkarni RR, Patki PS, Jog VP, et al. Treatment of osteoarthritis with a herbomineral formulation: A double-blind, placebo-controlled, cross-over study. J Ethnopharmacol 1991;33:91-5.
59. Greenwood J. Optimum vitamin C intake as a factor in the preservation of disc integrity. Med Ann District of Columbia 1964;33:274-6.
60. Lu J. J Tradit Chin Med The clinical application of yanglingquan (GB 34) point. 1993;13:179-81.
61. Shen X. Acupuncture treatment for kidney deficiency with combined application of points mingmen and guanyuan. J Tradit Chin Med 1996;16:275-7.
62. Sun LY.Efficacy of acupuncture in treating 100 cases of lumbago. J Tradit Chin Med 1987;7:23-4.
63. Wang YY. Electro-acupuncture treatment of 55 cases of soft tissue lumbar pain. J Tradit Chin Med 1987;7:72.
64. Weiss SL. Acupuncture in low back pain. Med Times 1975;103:137-9, 144-6.
65. Wilber MC.Sedation of active acupuncture loci in the management of low back pain. Am J Chin Med 1975;3:275-9.
66. Leung PC. Treatment of low back pain with acupuncture. Am J Chin Med 1979; 7:372-8.
67. MacPherson H, Gould AJ, Fitter M. Acupuncture for low back pain: results of a pilot study for a randomized controlled trial. Complement Ther Med 1999;7:83-90.
68. Junnila SY. Long-term treatment of chronic pain with acupuncture. Part I. Acupunct Electrother Res 1987;12:23-36.
69. Hackett GI, Seddon D, Kaminski D.Electroacupuncture compared with paracetamol for acute low back pain. Practitioner 1988;232:163-4.
70. Macdonald AJ, Macrae KD, Master BR, Rubin AP. Superficial acupuncture in the relief of chronic low back pain. Ann R Coll Surg Engl 1983;65:44-6.
71. Thomas M, Lundberg T. Importance of modes of acupuncture in the treatment of chronic nociceptive low back pain. Acta Anaesthesiol Scand 1994;38:63-9.
72. Edelist G, Gross AE, Langer F. Treatment of low back pain with acupuncture. Can Anaesth Soc J 1976;23:303-6.
73. Mendelson G, Selwood TS, Kranz H, et al. Acupuncture treatment of chronic back pain. A double-blind placebo-controlled trial. Am J Med 1983;74:49-55.
74. Lehmann TR, Russell DW, Spratt KF, et al. Efficacy of electroacupuncture and TENS in the rehabilitation of chronic low back pain patientsPain 1986;26:277-90.
75. Laitinen J. Acupuncture and transcutaneous electric stimulation in the treatment of chronic sacrolumbalgia and ischialgia. Am J Chin Med 1976;4:169-75.
76. Grant DJ, Bishop-Miller J, Winchester DM, et al. A randomized comparative trial of acupuncture versus transcutaneous electrical nerve stimulation for chronic back pain in the elderly. Pain 1999;82:9-13.
77. Wedenberg K, Moen B, Norling A. A prospective randomized study comparing acupuncture with physiotherapy for low-back and pelvic pain in pregnancy. Acta Obstet Gynecol Scand 2000;79:331-5.
78. Ernst E, White AR. Acupuncture for back pain: a meta-analysis of randomized controlled trials. Arch Intern Med 1998;158:2235-41.
79. van Tulder MW, Cherkin DC, Berman B, et al. The effectiveness of acupuncture in the management of acute and chronic low back pain. A systematic review within the framework of the Cochrane Collaboration Back Review Group. Spine 1999;24:1113-23.
80. Longworth W, McCarthy PW. A review of research on acupuncture for the treatment of lumbar disc protrusions and associated neurological symptomatology. J Altern Complement Med 1997;3:55-76 [review].
81. Bigos SJ, Bowyer O, Braen G, et al. Acute Low Back Problems in Adults. Clinical Practice Guideline, Number 14. AHCPR Publication No. 95-0642. Rockville, MD: Agency for Health Care Policy and Research, Public Health Service, US Department of Health and Human Services, December 1994, 34-6 [review].
82. Koes BW, Assendelft WJ, van der Heijden GJ, Bouter LM. Spinal manipulation for low back pain. An updated systematic review of randomized clinical trials. Spine 1996;21;2860-71 [review].
83. Verhoef MJ, Page SA, Waddell SC. The Chiropractic Outcome Study: pain, functional ability and satisfaction with care. J Manipulative Physiol Ther 1997;20:235-40.
84. Koes BW, Assendelft WJ, van der Heijden GJ, Bouter LM. Spinal manipulation for low back pain. An updated systematic review of randomized clinical trials. Spine 1996;21:2860-71 [review].
85. van Tulder MW, Koes BW, Bouter LM. Conservative treatment of acute and chronic nonspecific low back pain. A systematic review of randomized controlled trials of the most common interventions. Spine 1997;22:2128-56.
86. Skargren EI, Carlsson PG, Oberg BE. One-year follow-up comparison of the cost and effectiveness of chiropractic and physiotherapy as primary management for back pain. Subgroup analysis, recurrence, and additional health care utilization. Spine 1998;23:1875-83.
87. Andersson GBJ, Lucente T, Davis AM, et al. A comparison of osteopathic spinal manipulation with standard care for patients with low back pain. N Engl J Med 1999;341:1426-31.
88. Powell FC, Hanigan WC, Olivero WC. A risk/benefit analysis of spinal manipulation therapy for relief of lumbar or cervical pain. Neurosurgery 1993;33:73-8 [review].
89. Ye RB, Zhou JX, Gan MX. Clinical and CT analysis of 35 cases of lumbar disc herniation before and after non-operative treatment. Chung His I Chieh Ho Tsa Chih 1990;10:667-8645 [in Chinese].
90. Anonymous. Manipulation for sciatica: promising results. The BackLetter 1998;13:122, 125.
91. Kuo PP, Loh Z. Treatment of lumbar intervertebral disc protrusions by manipulation. Clin Orthop Rel Res 1987;215:47-55.
92. Chrisman D, Mittnacht A, Snook GA. A study of the results following rotatory manipulation in the lumbar intervertebral disc syndrome. J Bone Joint Surg 1964;46A:517-24.
93. Nwuga VCB. Relative therapeutic efficacy of vertebral manipulation and conventional treatment in back pain management. Am J Phys Med 1982;61:273-8.
94. Stern PJ, Cote P, Cassidy JD. A series of consecutive cases of low back pain with radiating leg pain treated by chiropractors. J Manipulative Physiol 1995;18:335-42.
95. Giles LG, Muller R. Chronic spinal pain syndromes: a clinical pilot trial comparing acupuncture, a nonsteroidal anti-inflammatory drug, and spinal manipulation. J Manipulative Physiol Ther 1999;22:376-81.
96. Ernst E. Massage therapy for low back pain: a systematic review. J Pain Symptom Manage 1999;17:65-9 [review].
97. Vlaeyen JW, Haazen IW, Schuerman JA, et al. Behavioural rehabilitation of chronic low back pain: comparison of an operant treatment, an operant-cognitive treatment and an operant-respondent treatment. Br J Clin Psychol 1995;34:95-118.
98. Newton-John TR, Spence SH, Schotte D. Cognitive-behavioural therapy versus EMG biofeedback in the treatment of chronic low back pain. Behav Res Ther 1995;33:691-7.
99. Bush C, Ditto B, Feuerstein M. A controlled evaluation of paraspinal EMG biofeedback in the treatment of chronic low back pain. Health Psychol 1985;4:307-21.
100. Stuckey SJ, Jacobs A, Goldfarb J. EMG biofeedback training, relaxation training, and placebo for the relief of chronic back pain. Percept Mot Skills 1986;63:1023-36.
101. Flor H, Birbaumer N. Comparison of the efficacy of electromyographic biofeedback, cognitive-behavioral therapy, and conservative medical interventions in the treatment of chronic musculoskeletal pain. J Consult Clin Psychol 1993;61:653-8.
102. Thomas E, Silman AJ, Croft PR, et al. Predicting who develops chronic low back pain in primary care: a prospective study. BMJ 1999;318:1662-7.
103. Heliovaara M, Knekt P, Aromaa A. Incidence and risk factors of herniated lumbar intervertebral disc or sciatica leading to hospitalization. J Chronic Dis 1987;40:251-8.
104. Dagenais S, Gay RE, Tricco AC, et al. NASS Contemporary Concepts in Spine Care: spinal manipulation therapy for acute low back pain. Spine J 2010;10:918-40.
105. Bronfort G, Evans R, Anderson AV, et al. Spinal manipulation, medication, or home exercise with advice for acute and subacute neck pain. Annals Intern Med 2012; 156:1-10.
106. von Heymann WJ, Schloemer P, Timm J, et al. Spinal HVLA-Manipulation in Acute Nonspecific LBP: A Double Blinded Randomized Controlled Trial in Comparison With Diclofenac and Placebo. Spine 2012 [E-pub ahead of print].
107. Leboeuf-Yde C, Yashin A. Smoking and low back pain: is the association real? J Manipulative Physiol Ther 1995;18:457-63 [review].
108. Leboeuf-Yde C, Kyvik KO, Bruun NH. Low back pain and lifestyle. Part 1: Smoking. Information from a population-based sample of 29,424 twins. Spine 1998;23:2207-13.
109. An HS, Silveri CP, Simpson JM, et al. Comparison of smoking habits between patients with surgically confirmed herniated lumbar and cervical disc disease and controls. J Spinal Disord 1994;7:369-73.
110. Battie MC, Videman T, Gill K, et al. 1991 Volvo Award in clinical sciences. Smoking and lumbar intervertebral disc degeneration: an MRI study of identical twins. Spine 1991;16:1015-21.
111. Ernst E. Smoking is a risk factor for spinal diseases. Hypothesis of the pathomechanism. Wien Klin Wochenschr 1992;104:626-30 [in German, review].
112. Rasmussen C. Lumbar disc herniation: favourable outcome associated with intake of wine. Eur Spine J 1998;7:24-8.
113. Salminen JJ, Erkintalo M, Laine M, Pentti J. Low back pain in the young. A prospective three-year follow-up study of subjects with and without low back pain. Spine 1995;20:2101-7.
114. Videman T, Battie MC, Gibbons LE, et al. Lifetime exercise and disk degeneration: an MRI study of monozygotic twins. Med Sci Sports Exerc 1997;29:1350-6.
115. Campello M. Nordin M. Weiser S. Physical exercise and low back pain. Scand J Med Sci Sports 1996;6:63-72 [review].
116. Manniche C. Assessment and exercise in low back pain. With special reference to the management of pain and disability following first time lumbar disc surgery. Dan Med Bull 1995;42:301-13 [review].
117. Torstensen TA, Ljunggren AE, Meen HD, et al. Efficiency and costs of medical exercise therapy, conventional physiotherapy, and self-exercise in patients with chronic low back pain. Spine 1998;23:2616-24.
118. Bentsen H, Lindgarde F, Manthorpe R. The effect of dynamic strength back exercise and/or a home training program in 57-year-old women with chronic low back pain. Results of a prospective randomized study with a 3-year follow-up period. Spine 1997;22:1494-500.
119. Hansen FR, Bendix T, Skov P, et al. Intensive, dynamic back-muscle exercises, conventional physiotherapy, or placebo-control treatment of low-back pain. A randomized, observer-blind trial. Spine 1993;18:98-108.
120. Friedrich M, Gittler G, Halberstadt Y, et al. Combined exercise and motivation program: effect on the compliance and level of disability of patients with chronic low back pain: a randomized controlled trial. Arch Phys Med Rehabil 1998;79:475-87.
121. Rosen NB, Hoffberg HJ. Conservative management of low back pain. Phys Med Rehabil Clin N Am 1998;9:435-64.
122. Waddell G, Feder G, Lewis M. Systematic reviews of bed rest and advice to stay active for acute low back pain. Br J Gen Pract 1997;47:647-52.
123. Allen C, Glasziou P, Del Mar C. Bed rest: a potentially harmful treatment needing more careful evaluation. Lancet 1999;354:1229-33 [review].
124. Bigos SJ, Bowyer O, Braen G, et al. Acute Low Back Problems in Adults. Clinical Practice Guideline, Number 14. AHCPR Publication No. 95-0642. Rockville, MD: Agency for Health Care Policy and Research, Public Health Service, US Department of Health and Human Services, December 1994, 34-6 [review].